Chemokines modulate glycan binding and the immunoregulatory activity of galectins - Laboratoire d'ingénierie des systèmes macromoléculaires Accéder directement au contenu
Article Dans Une Revue Communications Biology Année : 2021

Chemokines modulate glycan binding and the immunoregulatory activity of galectins

Résumé

Abstract Galectins are versatile glycan-binding proteins involved in immunomodulation. Evidence suggests that galectins can control the immunoregulatory function of cytokines and chemokines through direct binding. Here, we report on an inverse mechanism in which chemokines control the immunomodulatory functions of galectins. We show the existence of several specific galectin-chemokine binding pairs, including galectin-1/CXCL4. NMR analyses show that CXCL4 binding induces changes in the galectin-1 carbohydrate binding site. Consequently, CXCL4 alters the glycan-binding affinity and specificity of galectin-1. Regarding immunomodulation, CXCL4 significantly increases the apoptotic activity of galectin-1 on activated CD8 + T cells, while no effect is observed in CD4 + T cells. The opposite is found for another galectin-chemokine pair, i.e., galectin-9/CCL5. This heterodimer significantly reduces the galectin-9 induced apoptosis of CD4 + T cells and not of CD8 + T cells. Collectively, the current study describes an immunomodulatory mechanism in which specific galectin-chemokine interactions control the glycan-binding activity and immunoregulatory function of galectins.
Fichier principal
Vignette du fichier
s42003-021-02922-4.pdf (2.79 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03872175 , version 1 (16-06-2023)

Identifiants

Citer

Lucía Sanjurjo, Iris Schulkens, Pauline Touarin, Roy Heusschen, Ed Aanhane, et al.. Chemokines modulate glycan binding and the immunoregulatory activity of galectins. Communications Biology, 2021, 4 (1), pp.1415. ⟨10.1038/s42003-021-02922-4⟩. ⟨hal-03872175⟩
13 Consultations
7 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More