Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia - Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie Accéder directement au contenu
Article Dans Une Revue Journal of Magnetism and Magnetic Materials Année : 2023

Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia

Résumé

Iron-oxide nanoparticles synthesized by magnetotactic bacteria can be used in cancer treatment by means of magnetic hyperthermia. In order to study the structural properties of samples through the successive steps of their production from cultivated magnetotactic bacteria to coated magnetosomes, and their effect on magnetic properties, we performed a combination of (cryo-)Transmission Electron Microscopy observations and magnetic hysteresis as well as First-Order Reversal Curve diagrams at low temperature. The anisotropy of magnetic interactions was investigated by recording field-cooled FORC diagrams with a measuring field either parallel or perpendicular to the field-cooling direction. The results from the various techniques are in very good agreement. We found that magnetosomes in magnetotactic bacteria are arranged in chains and have magnetic properties typical of stable single-domain aligned particles. Extracted magnetosomes form clusters of interacting maghemite particles with some remaining chains, while purified magnetosomes are solely arranged in clusters. Finally, magnetosomes coated with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) are still organized in clusters but with less magnetostatic interactions than in purified magnetosomes, while magnetosomes coated with citric acid tend to recover a chained structure forming loops. The main features observed on the FORC diagrams are consistent with the various arrangement observed. Lastly, hyperthermia properties were measured for the two coated samples and we found that magnetosomes coated with citric acid display a higher Specific Absorption Rate and therefore hold a better potential for biomedical applications.
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Dates et versions

hal-04093875 , version 1 (10-05-2023)

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Claire Carvallo, Anaïs Fondet, Raphaël Le Fèvre, Dario Taverna, Yohan Guyodo, et al.. Magnetic and structural properties of biogenic magnetic nanoparticles along their production process for use in magnetic hyperthermia. Journal of Magnetism and Magnetic Materials, 2023, 575, pp.170726. ⟨10.1016/j.jmmm.2023.170726⟩. ⟨hal-04093875⟩
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