Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials - Institut Charles Gerhardt - Institut de Chimie Moléculaire et des Matériaux de Montpellier
Article Dans Une Revue Chemistry - A European Journal Année : 2020

Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials

Résumé

A simple and efficient way to synthesize peptide-containing silicone materials is described. Silicone oils containing a chosen ratio of bioactive peptide sequences were prepared by acid-catalyzed copolymerization of dichlorodimethylsilane, hybrid dichloromethyl peptidosilane and either Si-vinyl or Si-H functionalized monomers. Functionalized silicone oils were first obtained and then after hydrosilylation cross-linking, bioactive PDMS based materials were straightforward obtained. The introduction of an antibacterial peptide yields PDMS materials showing an interesting activity against Staphylococcus Aureus. In the same way, RGD ligands-containing PDMS demonstrated improved cell adhesion properties. This generic method was fully compatible with the stability of peptides and thus opened the way to the synthesis of a wide range of biologically active silicones.
Fichier principal
Vignette du fichier
2020-Martin et al-Direct synthesis of peptide‐containing silicone. A new way for bioactive materials.pdf (1.23 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04816986 , version 1 (03-12-2024)

Licence

Copyright (Tous droits réservés)

Identifiants

Citer

Julie Martin, Mohammad Wehbi, Cécile Echalier, Sylvie Hunger, Audrey Bethry, et al.. Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials. Chemistry - A European Journal, 2020, 26, pp.12839 - 12845. ⟨10.1002/chem.202001571⟩. ⟨hal-04816986⟩
42 Consultations
0 Téléchargements

Altmetric

Partager

More