Amide bioisosteric replacement in the design and synthesis of quorum sensing modulators - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) European Journal of Medicinal Chemistry Année : 2024

Amide bioisosteric replacement in the design and synthesis of quorum sensing modulators

Résumé

The prevention or control of bacterial infections requires continuous search for novel approaches among which bacterial quorum sensing inhibition is considered as a complementary antibacterial strategy. Quorum sensing, used by many different bacteria, functions through a cell-to-cell communication mechanism relying on chemical signals, referred to as autoinducers, such as N-acyl homoserine lactones (AHLs) which are the most common chemical signals in this system. Designing analogs of these autoinducers is one of the possible ways to interfere with quorum sensing. Since bioisosteres are powerful tools in medicinal chemistry, targeting analogs of AHLs or other signal molecules and mimics of known QS modulators built on amide bond bioisosteres is a relevant strategy in molecular design and synthetic routes. This review highlights the application of amide bond bioisosteric replacement in the design and synthesis of novel quorum sensing inhibitors.
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Dates et versions

hal-04583812 , version 1 (22-05-2024)

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Qiang Zhang, Laurent Soulère, Yves Queneau. Amide bioisosteric replacement in the design and synthesis of quorum sensing modulators. European Journal of Medicinal Chemistry, In press, ⟨10.1016/j.ejmech.2024.116525⟩. ⟨hal-04583812⟩
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