Abstract. This study delves into the characterisation of a heterogenous reservoir, the Tchirezrine II sandstone unit in northern Niger. The characterisation is crucial for potential uranium in situ recovery (ISR) in a naturally fractured and faulted context. Employing a multifaceted approach, including well log data, optical borehole imagery, and hydrogeological tests, alongside satellite-based lineament analysis, this study provides a comprehensive understanding of the structures and their impact on fluid flow. Lineament analysis reveals scale-dependent patterns, consistent with spatially homogeneous joint networks restricted to mechanical units, as well as nearly scale-invariant patterns, better corresponding to spatially heterogeneous fault networks. Various deformation structures are detected from borehole imagery, including extensional fractures, cataclastic deformation bands, and brecciated–cataclastic fault cores. Based on well log data, the Tchirezrine II reservoir displays heterogeneous porosity and permeability related to its fluvial context. These data differ from the traditional porosity–permeability relationship obtained in a sandstone reservoir matrix but are instead consistent with Nelson's classification, emphasising the impact of deformation structures on such petrophysical properties. Hydrological tests have been implemented into a zone of E–W-trending deformation structures, revealing a strong permeability anisotropy. This strong E–W anisotropy is consistent with the presence of the observed E–W structures, i.e. with a draining behaviour of extensional open fractures and a sealing behaviour of both cataclastic bands and fault rocks. Considering implications for ISR mining, this study allows the discussion of the interplay between fractures, faults, and fluid flow properties. It suggests that a well pattern perpendicular to the main permeability orientation can attenuate channelled flow, thus improving the contact of the leach solution with the mineralised matrix. These results provide an integrated approach and a multi-scale characterisation of naturally fractured reservoir (NFR) properties in sandstone, offering a basis for the optimisation of NFR production such as ISR development.