Evaluation of health related quality of life in children with immune thrombocytopenia with the PedsQLTM 4.0 Generic core scales: a study on behalf of the pays de Loire pediatric hematology network. - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Article Dans Une Revue Health and Quality of Life Outcomes Année : 2013

Evaluation of health related quality of life in children with immune thrombocytopenia with the PedsQLTM 4.0 Generic core scales: a study on behalf of the pays de Loire pediatric hematology network.

Eliane Tarral
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Christophe Savagner
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Sylvaine Poignant
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Arnaud Boutet
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Joachim Bassil
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Dominique Médinger
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Emmanuel Quemener
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Nancy Young
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Robert Klaassen
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Résumé

BACKGROUND: Immune thrombocytopenia (ITP) is a childhood disorder that is often life-altering for children and their parents. Health related quality of life (HRQL) has never been chronologically monitored in children with ITP. We initiated a prospective study to assess HRQL from diagnosis to six months and define factors that influence this outcome in children with ITP. METHODS: 73 children with acute ITP aged from 2 to 18 years were prospectively enrolled in the study. According to the presence of bleeding, they were or were not given a 4-day course of corticosteroid treatment. The PedsQLTM 4.0 Generic Core Scale was completed by children and parents upon their inclusion in the study and 6 months after diagnosis. RESULTS: Over the six month period, quality of life improved in terms of their global, physical and psychosocial well-being for 54.5 %, 35.6 % and 36.2 % of patients respectively. This improvement is clinically relevant compared to scores at diagnosis, corresponding at least to a minimal clinically important difference (MCID). Factors such as sex, age, platelet count, bleeding scores, bone marrow aspiration and persistence of ITP at 6 months were not significantly associated with HRQL scores. However, preceding viral infection was identified to have an impact on HRQL. CONCLUSIONS: This first longitudinal study assessing HRQL in children with ITP reveals a global improvement in PedSQLTM 4.0. However, these results should be considered with caution since our data also confirm that self-report HRQL scores are not influenced by any analyzed biologic or clinical parameters. Others tools, such as Kids' ITP Tools, would probably be required to assess the HRQL of this population.Trial registration: Trial registration clinical trials.gov Identifier: NCT00331357.
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Dates et versions

inserm-00905117 , version 1 (16-11-2013)

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Marion Strullu, Josué Rakotonjanahary, Eliane Tarral, Christophe Savagner, Caroline Thomas, et al.. Evaluation of health related quality of life in children with immune thrombocytopenia with the PedsQLTM 4.0 Generic core scales: a study on behalf of the pays de Loire pediatric hematology network.. Health and Quality of Life Outcomes, 2013, 11 (1), pp.193. ⟨10.1186/1477-7525-11-193⟩. ⟨inserm-00905117⟩
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