Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation - Archive ouverte HAL Access content directly
Journal Articles Journal of Nutritional Biochemistry Year : 2014

Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation

, (1) , (1) , (1) , (1) , (2) , (3) , (4) , (5) , (3) , (1)
1
2
3
4
5

Abstract

Prospective studies reported an inverse correlation between 25-hydroxyvitamin D [25(OH)D] plasma levels and prevalence of obesity and type 2 diabetes. In addition, 25(OH)D status may be a determinant of obesity onset. However, the causality between these observations is not yet established. We studied the preventive effect of vitamin D3 (VD3) supplementation (15,000IU/kg of food for 10weeks) on onset of obesity in a diet-induced obesity mouse model. We showed that the VD3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis. The limitation of weight gain could further be explained by an increased lipid oxidation, possibly due to an up-regulation of genes involved in fatty acid oxidation and mitochondrial metabolism, leading to increased energy expenditure. Altogether, these data show that VD3 regulates energy expenditure and suggest that VD3 supplementation may represent a strategy of preventive nutrition to fight the onset of obesity and associated metabolic disorders
Not file

Dates and versions

hal-01478368 , version 1 (28-02-2017)

Identifiers

Cite

Julie Marcotorchino, Franck Tourniaire, Julien Astier, Esma Karkeni, Matthias Canault, et al.. Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation. Journal of Nutritional Biochemistry, 2014, 25 (10), pp.1077 - 1083. ⟨10.1016/j.jnutbio.2014.05.010⟩. ⟨hal-01478368⟩
113 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More