Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART - Centre International de Recherche en Infectiologie Accéder directement au contenu
Article Dans Une Revue International Journal of Infectious Diseases Année : 2024

Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART

Bertrand Dussol
  • Fonction : Auteur
Florence Galtier
  • Fonction : Auteur
Sylvain Jaffuel
  • Fonction : Auteur
Alain Makinson
  • Fonction : Auteur

Résumé

BACKGROUND: This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in PWH and HIV-negative individuals. METHODS: We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (< 200/mm(3) and ≥ 200/mm(3) CD4 cell counts) at 1, 6 and 12 months after primary vaccination. RESULTS: A total of 1776 participants were included in this analysis, 684 PWH (99% were on ART, median CD4 counts 673 cells/mm(3)) and 1092 controls. At 1 month, after adjustment on age, sex and BMI, PWH had lower seroneutralization titers than controls and PWH with < 200 CD4 cell/mm3 had lower anti- Spike SARS-CoV-2 IgG antibodies. Same results were found at 6 months. However, in participants who received a booster dose between 6 and 12 months post primary vaccination, we did not observe differences between PWH and controls at 12 months. CONCLUSION: PWH had high responses to primary mRNA COVID-19 vaccination. In those who received a booster dose after six months, the humoral response at 12 months increased to similar levels to controls, even in those with low CD4 counts at baseline.
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hal-04627501 , version 1 (27-06-2024)

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Paul Loubet, Jean-Daniel Lelievre, Alexis Francois, Elisabeth Botelho-Nevers, Christian Chidiac, et al.. Humoral response after mRNA COVID-19 primary vaccination and single booster dose in people living with HIV compared to controls: a French nationwide multicenter cohort study - ANRS0001s COV-POPART. International Journal of Infectious Diseases, 2024, 146, pp.107110. ⟨10.1016/j.ijid.2024.107110⟩. ⟨hal-04627501⟩
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