Knockdown of Ebola Virus VP24 Impairs Viral Nucleocapsid Assembly and Prevents Virus Replication - CIRI - Bases moléculaires de la pathogénicité virale Accéder directement au contenu
Article Dans Une Revue Journal of Infectious Diseases Année : 2011

Knockdown of Ebola Virus VP24 Impairs Viral Nucleocapsid Assembly and Prevents Virus Replication

Résumé

The structural protein VP24 of Ebola virus (EBOV) is a determinant of virulence in rodent models and possesses an interferon antagonist function. In this study, we investigate the role of VP24 in EBOV replication using RNA interference by small interfering RNA to knock down the expression of this protein in virus-infected cells. We reveal that VP24 is required for assembly of viral nucleocapsids and that silencing of VP24 expression prevents the release of EBOV.

Domaines

Virologie

Dates et versions

hal-02864176 , version 1 (10-06-2020)

Identifiants

Citer

Mathieu Mateo, Caroline Carbonnelle, Miguel Martinez, Olivier Reynard, Audrey Page, et al.. Knockdown of Ebola Virus VP24 Impairs Viral Nucleocapsid Assembly and Prevents Virus Replication. Journal of Infectious Diseases, 2011, 204 (suppl_3), pp.S892-S896. ⟨10.1093/infdis/jir311⟩. ⟨hal-02864176⟩
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