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Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods.
Christelle Reynès
,
Hélène Host
,
Anne-Claude Camproux
,
Guillaume Laconde
,
Florence Leroux
,
et al.
Journal articles
inserm-00705646v1
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Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches
Baptiste Villemagne
,
Marion Flipo
,
Nicolas Blondiaux
,
Celine Crauste
,
Sandra Malaquin
,
et al.
Journal articles
hal-02309782v1
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Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor
Vanessa Hoguet
,
Manuel Lasalle
,
Mathieu Maingot
,
Geoffroy Dequirez
,
Rajaa Boulahjar
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et al.
Journal articles
hal-03185533v1
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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox
Paul Hermant
,
Damien Bosc
,
Catherine Piveteau
,
Ronan Gealageas
,
Baovy Lam
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et al.
Journal articles
hal-03054238v1
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Drug Target Engagement using coupled Cellular Thermal Shift Assay -acoustic Reverse Phase Protein Array
Adrien Herledan
,
Marine Andres
,
Aurore Lejeune-Dodge
,
Florence Leroux
,
Alexandre Biela
,
et al.
Journal articles
hal-03051837v1
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Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology
Sandrine Belouzard
,
Arnaud Machelart
,
Valentin Sencio
,
Thibaut Vausselin
,
Eik Hoffmann
,
et al.
2021
Preprints, Working Papers, ...
hal-03357964v1
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Modulators of hERAP2 discovered by High-Throughput Screening
Laura Medve
,
Ronan Gealageas
,
Vy Lam Bao
,
Valentin Guillaume
,
Omar Castillo-Aguilera
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et al.
Journal articles
hal-03059990v1
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Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening
Léo Faion
,
Kamel Djaout
,
Rosangela Frita
,
Catalin Pintiala
,
Francois-Xavier Cantrelle
,
et al.
Journal articles
hal-02988077v1
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Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737
Anne-Laure Mathieu
,
Olivier Sperandio
,
Virginie Pottiez
,
Sophie Balzarin
,
Adrien Herlédan
,
et al.
Journal articles
hal-01911441v1
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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance
Manuel Lasalle
,
Vanessa Hoguet
,
Nathalie Hennuyer
,
Florence Leroux
,
Catherine Piveteau
,
et al.
Journal articles
inserm-02115415v1
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Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification
Léo Faïon
,
Kamel Djaout
,
Catalin Pintiala
,
Catherine Piveteau
,
Florence Leroux
,
et al.
Journal articles
hal-04007450v1
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BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation
Maxime Sartori
,
Tiago P. Mendes
,
Shruti Desai
,
Alessia Lasorsa
,
Adrien Herledan
,
et al.
Journal articles
hal-02337166v1
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Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors
Rébecca F. Déprez-Poulain
,
Marion Flipo
,
Catherine Piveteau
,
Florence Leroux
,
Sandrine Dassonneville
,
et al.
Journal articles
hal-03051765v1
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A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2
Hugues Prevet
,
Martin Moune
,
Abdalkarim Tanina
,
Christian Kemmer
,
Adrien Herledan
,
et al.
Journal articles
hal-03102744v1
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Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity
Baptiste Villemagne
,
Arnaud Machelart
,
Ngoc Chau Tran
,
Marion Flipo
,
Martin Moune
,
et al.
Journal articles
hal-03096012v1
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Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening
Florence Leroux
,
Damien Bosc
,
Terence Beghyn
,
Paul Hermant
,
Sandrine Warenghem
,
et al.
Journal articles
hal-03243182v1
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
Rebecca Déprez-Poulain
,
Nathalie Hennuyer
,
Damien Bosc
,
Wenguang Liang
,
Emmanuelle Enée
,
et al.
Journal articles
hal-02511111v1
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Identification of indole-based activators of insulin degrading enzyme
Nicolas Kraupner
,
Chau Phi Dinh
,
Xiaoan Wen
,
Valérie Landry
,
Adrien Herledan
,
et al.
Journal articles
hal-03430475v1
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ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease
Florent Letronne
,
Geoffroy Laumet
,
Anne-Marie Ayral
,
Julien Chapuis
,
Florie Demiautte
,
et al.
Journal articles
hal-02155738v1
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Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?
Laetitia Lesire
,
Florence Leroux
,
Rebecca Déprez-Poulain
,
Benoit Deprez
Journal articles
hal-03657094v1
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