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Françoise Ochsenbein , Xavier Morelli , Chandra Verma
Progress in Biophysics and Molecular Biology, 2015, 119 (1), pp.1
Journal articles hal-01201641v1
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Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis

Amandine Cartier-Michaud , Anne-Laure Bailly , Stéphane Betzi , Xiaoli Shi , Jean-Claude Lissitzky , et al.
PLoS Genetics, 2017, 13 (6), ⟨10.1371/journal.pgen.1006803⟩
Journal articles hal-01542697v1
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Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer

Laetitia Ganier , Stéphane Betzi , Carine Derviaux , Philippe Roche , Charlotte Dessaux , et al.
ACS Chemical Biology, 2022, 17 (5), pp.1061-1072. ⟨10.1021/acschembio.1c00826⟩
Journal articles hal-03817750v1
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In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

Jeremy Ariey‐bonnet , Kendall Carrasco , Marion Le Grand , Laurent Hoffer , Stéphane Betzi , et al.
Molecular Oncology, 2020, 14, pp.3083 - 3099. ⟨10.1002/1878-0261.12810⟩
Journal articles hal-02989358v1
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Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Jessica Hernandez , Laurent Hoffer , Bruno Coutard , Gilles Quérat , Philippe Roche , et al.
European Journal of Medicinal Chemistry, 2019, 161 (4), pp.323-333. ⟨10.1016/j.ejmech.2018.09.056⟩
Journal articles inserm-02378768v1
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2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions

Marie-Jeanne Basse , Stéphane Betzi , Xavier Morelli , Philippe Roche
Database - The journal of Biological Databases and Curation, 2016, 2016, pp.6. ⟨10.1093/database/baw007⟩
Journal articles hal-01307114v1
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Rôle en cancérologie et ciblage du récepteur à activité tyrosine kinase PTK7

Laetitia Ganier , Xavier Morelli , Jean-Paul Borg
Médecine/Sciences, 2020, ⟨10.1051/medsci/2020197⟩
Journal articles hal-03152194v1
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Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions

Nicolas Bosc , Christophe Muller , Laurent Hoffer , David Lagorce , Stéphane Bourg , et al.
ACS Chemical Biology, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
Journal articles hal-02569625v1

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Laurent Hoffer , Yuliia Voitovich , Brigitt Raux , Kendall Carrasco , Christophe Muller , et al.
Journal of Medicinal Chemistry, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩
Journal articles hal-02067797v1

Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.

Olivier Bornet , Matthieu Nouailler , Michaël Feracci , Corinne Sebban-Kreuzer , Deborah Byrne , et al.
FEBS Letters, 2014, 588 (12), pp.2031--6. ⟨10.1016/j.febslet.2014.04.029⟩
Journal articles hal-01458194v1
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The NANOTUMOR consortium - Towards the Tumor Cell Atlas

Florent Colin , Kristine Schauer , Ali Hamiche , Pierre Martineau , Jean-Paul Borg , et al.
Biology of the Cell, 2021, 113 (6), pp.272-280. ⟨10.1111/boc.202000135⟩
Journal articles hal-03169719v1
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Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML).

Emilie Coppin , Véronique Gelsi-Boyer , Xavier Morelli , Nathalie Cervera , Anne Murati , et al.
Leukemia, 2014, 29 (2), pp.500-2. ⟨10.1038/leu.2014.288⟩
Journal articles inserm-01069773v1

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR.

Cedric Bernard , Stéphane Gely , Jean-Marie Bourhis , Xavier Morelli , Sonia Longhi , et al.
FEBS Letters, 2009, 583 (7), pp.1084-9. ⟨10.1016/j.febslet.2009.03.004⟩
Journal articles hal-00473784v1
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Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

Kahina Hammam , Magali Saez-Ayala , Etienne Rebuffet , Laurent Gros , Sophie Lopez , et al.
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
Journal articles hal-01643359v1

Alteration of a Single Tryptophan Residue of the Cellulose-binding Domain Blocks Secretion of the Erwinia chrysanthemi Cel5 Cellulase (ex-EGZ) via the Type II System

Virginie Chapon , Helen D Simpson , Xavier Morelli , Emmanuel Brun , Frederic Barras
Journal of Molecular Biology, 2000, 303, pp.117-123. ⟨10.1006/jmbi.2000.4103⟩
Journal articles istex hal-01560905v1
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Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

Céline Contesto-Richefeu , Nicolas Tarbouriech , Xavier Brazzolotto , Stéphane Betzi , Xavier Morelli , et al.
PLoS Pathogens, 2014, 10 (3), pp.e1003978. ⟨10.1371/journal.ppat.1003978⟩
Journal articles hal-01132360v1
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CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation

Kendall Carrasco , Camille Montersino , Carine Derviaux , Magali Saez-Ayala , Laurent Hoffer , et al.
Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩
Journal articles hal-03624836v1

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Stéphane Betzi , Audrey Restouin , Sandrine Opi , Stefan T Arold , Isabelle Parrot , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (49), pp.19256-61. ⟨10.1073/pnas.0707130104⟩
Journal articles hal-00473817v1
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Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

Xiaoli Shi , Stéphane Betzi , Adrien Lugari , Sandrine Opi , Audrey Restouin , et al.
FEBS Letters, 2012, 586, pp.1759-1764. ⟨10.1016/j.febslet.2012.05.017⟩
Journal articles hal-00717171v1

A specific protein disorder catalyzer of HIV-1 Nef

Adrien Lugari , Sebastian Breuer , Thibault Coursindel , Sandrine Opi , Audrey Restouin , et al.
Bioorganic and Medicinal Chemistry, 2011, 19, pp.7401-7406. ⟨10.1016/j.bmc.2011.10.051⟩
Journal articles istex hal-00662295v1
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Structural and Genetic Analyses Reveal a Key Role in Prophage Excision for the TorI Response Regulator Inhibitor

Latifa Elantak , Mireille Ansaldi , Francoise Guerlesquin , Vincent Méjean , Xavier Morelli
Journal of Biological Chemistry, 2005, 280 (44), pp.36802-36808. ⟨10.1074/jbc.m507409200⟩
Journal articles hal-02018141v1
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CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy

Laurent Hoffer , Magali Saez-Ayala , Dragos Horvath , Alexandre Varnek , Xavier Morelli , et al.
Journal of Chemical Information and Modeling, 2019, 59 (4), pp.1472-1485. ⟨10.1021/acs.jcim.8b00960⟩
Journal articles hal-02145507v1
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Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches

Laurent Hoffer , Christophe Muller , Philippe Roche , Xavier Morelli
Molecular Informatics, 2018, 37 (9-10), pp.1800059. ⟨10.1002/minf.201800059⟩
Journal articles hal-02145522v1

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain and ALG-2-interacting protein X

Xiaoli Shi , Sandrine Opi , Adrien Lugari , Audrey Restouin , Thibault Coursindel , et al.
Biochemical Journal, 2010, 431, pp.93-102. ⟨10.1042/BJ20100314⟩
Journal articles hal-00600207v1

Solution structure of HndAc: a thioredoxin-like domain involved in the NADP-reducing hydrogenase complex.

Matthieu Nouailler , Xavier Morelli , Olivier Bornet , Bernard Chetrit , Zorah Dermoun , et al.
Protein Science, 2006, 15 (6), pp.1369-78. ⟨10.1110/ps.051916606⟩
Journal articles hal-00475666v1
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Identification and biophysical assessment of the molecular recognition mechanisms between the human hemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

Xiaoli Shi , Sandrine Opi , Adrien Lugari , Audrey Restouin , Thibault Coursindel , et al.
Biochemical Journal, 2010, 431 (1), pp.93-102. ⟨10.1042/BJ20100314⟩
Journal articles hal-00517249v1
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Stereoselective synthesis of original spirolactams displaying promising folded structures.

Guilhem Chaubet , Thibault Coursindel , Xavier Morelli , Stéphane Betzi , Philippe Roche , et al.
Organic & Biomolecular Chemistry, 2013, 11 (28), pp.4719-26. ⟨10.1039/c3ob40643a⟩
Journal articles hal-00871067v1
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CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

Françoise Gondois-Rey , Thomas Miller , Vladimir Laletin , Xavier Morelli , Yves Collette , et al.
Frontiers in Immunology, 2022, 13, pp.899068. ⟨10.3389/fimmu.2022.899068⟩
Journal articles hal-03857250v1
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Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach

Laurent Hoffer , Manon Garcia , Raphael Leblanc , Mikael Feracci , Stéphane Betzi , et al.
Journal of Medicinal Chemistry, 2023, ⟨10.1021/acs.jmedchem.2c01569⟩
Journal articles hal-04048842v1

Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides

Pierre Stocker , Jean Michel Brunel , Leandro De Rezende , Antonia Tavares-Do Amaral , Xavier Morelli , et al.
Biochimie, 2012, 94 (8), pp.1668-1675. ⟨10.1016/j.biochi.2012.01.006⟩
Journal articles istex hal-01460427v1