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Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex

Y. Cherrak , I. Filella-Merce , V. Schmidt , D. Byrne , V. Sgoluppi , et al.
mBio, 2021, 12 (4), ⟨10.1128/mbio.01348-21⟩
Journal articles pasteur-03429012v1

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Laurent Hoffer , Yuliia Voitovich , Brigitt Raux , Kendall Carrasco , Christophe Muller , et al.
Journal of Medicinal Chemistry, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩
Journal articles hal-02067797v1

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Brigitt Raux , Yuliia Voitovich , Carine Derviaux , Adrien Lugari , Etienne Rebuffet , et al.
Journal of Medicinal Chemistry, 2016, 59 (4, SI), pp.1634-1641. ⟨10.1021/acs.jmedchem.5b01708⟩
Journal articles hal-01439086v1
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Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer

Melissa Birol , Radoslav Ivanov Enchev , André Padilla , Florian Stengel , Ruedi Aebersold , et al.
PLoS ONE, 2014, 9 (8), pp.e105688. ⟨10.1371/journal.pone.0105688⟩
Journal articles hal-02359383v1

Protein-Protein Interaction Inhibition (2P21)-Oriented Chemical Library Accelerates Hit Discovery

Sabine Milhas , Brigitt Raux , Stéphane Betzi , Carine Derviaux , Philippe Roche , et al.
ACS Chemical Biology, 2016, 11 (8), pp.2140-2148. ⟨10.1021/acschembio.6b00286⟩
Journal articles hal-01439116v1
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2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions

Marie-Jeanne Basse , Stéphane Betzi , Xavier Morelli , Philippe Roche
Database - The journal of Biological Databases and Curation, 2016, 2016, pp.6. ⟨10.1093/database/baw007⟩
Journal articles hal-01307114v1
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Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions

Jeremy Bonzi , Olivier Bornet , Stéphane Betzi , Brian T Kasper , Lara K Mahal , et al.
Nature Communications, 2015, 6 (1), pp.6194. ⟨10.1038/ncomms7194⟩
Journal articles hal-02018118v1
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Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis

Amandine Cartier-Michaud , Anne-Laure Bailly , Stéphane Betzi , Xiaoli Shi , Jean-Claude Lissitzky , et al.
PLoS Genetics, 2017, 13 (6), ⟨10.1371/journal.pgen.1006803⟩
Journal articles hal-01542697v1
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Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer

Laetitia Ganier , Stéphane Betzi , Carine Derviaux , Philippe Roche , Charlotte Dessaux , et al.
ACS Chemical Biology, 2022, 17 (5), pp.1061-1072. ⟨10.1021/acschembio.1c00826⟩
Journal articles hal-03817750v1
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In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

Jeremy Ariey‐bonnet , Kendall Carrasco , Marion Le Grand , Laurent Hoffer , Stéphane Betzi , et al.
Molecular Oncology, 2020, 14, pp.3083 - 3099. ⟨10.1002/1878-0261.12810⟩
Journal articles hal-02989358v1

Accelerating small compounds discovery targeting protein-protein interaction

S. Milhas , S. Betzi , P. Roche , M. Cholay , A. Restouin , et al.
FEBS Journal, 2015, 282 (1, SI), pp.134
Journal articles hal-01439038v1
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Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach

Laurent Hoffer , Manon Garcia , Raphael Leblanc , Mikael Feracci , Stéphane Betzi , et al.
Journal of Medicinal Chemistry, 2023, ⟨10.1021/acs.jmedchem.2c01569⟩
Journal articles hal-04048842v1
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Stereoselective synthesis of original spirolactams displaying promising folded structures.

Guilhem Chaubet , Thibault Coursindel , Xavier Morelli , Stéphane Betzi , Philippe Roche , et al.
Organic & Biomolecular Chemistry, 2013, 11 (28), pp.4719-26. ⟨10.1039/c3ob40643a⟩
Journal articles hal-00871067v1
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CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation

Kendall Carrasco , Camille Montersino , Carine Derviaux , Magali Saez-Ayala , Laurent Hoffer , et al.
Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩
Journal articles hal-03624836v1

Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer

Melissa Birol , Radoslav Ivanov Enchev , André Padilla , Florian Stengel , Ruedi Aebersold , et al.
PLoS ONE, 2014, 9 (8), pp.e105688. ⟨10.1371/journal.pone.0105688⟩
Journal articles hal-03726696v1

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Stéphane Betzi , Audrey Restouin , Sandrine Opi , Stefan T Arold , Isabelle Parrot , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (49), pp.19256-61. ⟨10.1073/pnas.0707130104⟩
Journal articles hal-00473817v1
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Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

Xiaoli Shi , Stéphane Betzi , Adrien Lugari , Sandrine Opi , Audrey Restouin , et al.
FEBS Letters, 2012, 586, pp.1759-1764. ⟨10.1016/j.febslet.2012.05.017⟩
Journal articles hal-00717171v1

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Mickaël Bouvet , Adrien Lugari , Clara C. Posthuma , Jessika C. Zevenhoven , Stéphanie Bernard , et al.
Journal of Biological Chemistry, 2014, 289 (37), pp.25783-25796. ⟨10.1074/jbc.M114.577353⟩
Journal articles hal-01910944v1
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Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

Kahina Hammam , Magali Saez-Ayala , Etienne Rebuffet , Laurent Gros , Sophie Lopez , et al.
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩
Journal articles hal-01643359v1
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Revisiting the molecular interactions between the tumor protein TCTP and the drugs sertraline/thioridazine.

Florian Malard , Eric Jacquet , Naima Nhiri , Christina Sizun , Amélie Chabrier , et al.
ChemMedChem, 2022, 17 (1), pp.e202100528. ⟨10.1002/cmdc.202100528⟩
Journal articles hal-03370569v2
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Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island

Julie Piron , Stéphane Betzi , Jessica Pastour , Audrey Restouin , Remy Castellano , et al.
PeerJ, 2022, 10, pp.e13955. ⟨10.7717/peerj.13955⟩
Journal articles hal-03803766v1
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Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

Céline Contesto-Richefeu , Nicolas Tarbouriech , Xavier Brazzolotto , Stéphane Betzi , Xavier Morelli , et al.
PLoS Pathogens, 2014, 10 (3), pp.e1003978. ⟨10.1371/journal.ppat.1003978⟩
Journal articles hal-01132360v1

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

Davide Normanno , Aurélie Négrel , Abinadabe J de Melo , Stéphane Betzi , Katheryn Meek , et al.
Journal articles hal-01541119v1
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Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

R. Leblanc , R. Kashyap , K. Barral , A.L. Egea‐jimenez , D. Kovalskyy , et al.
Journal of Extracellular Vesicles, 2020, 10 (2), ⟨10.1002/jev2.12039⟩
Journal articles hal-03152593v1

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.

Stéphane Betzi , Cécilia Eydoux , Cécile Bussetta , Marilyne Blemont , Pieter Leyssen , et al.
Antiviral Research, 2009, 84 (1), pp.48-59. ⟨10.1016/j.antiviral.2009.06.009⟩
Journal articles istex hal-00418783v1

GFscore: a general nonlinear consensus scoring function for high-throughput docking.

Stéphane Betzi , Karsten Suhre , Bernard Chétrit , Françoise Guerlesquin , Xavier Morelli
Journal of Chemical Information and Modeling, 2006, 46 (4), pp.1704-12. ⟨10.1021/ci0600758⟩
Journal articles istex hal-00475665v1