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Functional Characterisation of Three O-methyltransferases Involved in the Biosynthesis of Phenolglycolipids in Mycobacterium tuberculosis

Roxane Simeone , Gaëlle Huet , Patricia Constant , Wladimir Malaga , Anne Lemassu , et al.
PLoS ONE, 2013, 8 (3), pp.e58954. ⟨10.1371/journal.pone.0058954⟩
Journal articles hal-02391855v1
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Insights on the emergence of Mycobacterium tuberculosis from the analysis of Mycobacterium kansasii.

Joyce Wang , Fiona Mcintosh , Nicolas Radomski , Ken Dewar , Roxane Simeone , et al.
Genome Biology and Evolution, 2015, 7 (3), pp.856-70. ⟨10.1093/gbe/evv035⟩
Journal articles pasteur-01352692v1
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Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

Roxane Simeone , Fadel Sayes , Okryul Song , Matthias I Gröschel , Priscille Brodin , et al.
PLoS Pathogens, 2015, 11 (2), pp.e1004650. ⟨10.1371/journal.ppat.1004650⟩
Journal articles pasteur-02615223v1
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Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors

Jacques Augenstreich , Evert Haanappel , Fadel Sayes , Roxane Simeone , Valerie Guillet , et al.
Frontiers in Cellular and Infection Microbiology, 2020, 10, pp.420. ⟨10.3389/fcimb.2020.00420⟩
Journal articles pasteur-02873531v1

Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis

Roxane Simeone , Patricia Constant , Wladimir Malaga , Christophe Guilhot , Mamadou Daffé , et al.
FEBS Journal, 2007, 274 (8), pp.1957-1969. ⟨10.1111/j.1742-4658.2007.05740.x⟩
Journal articles pasteur-02862986v1

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis

Daria Bottai , Laleh Majlessi , Roxane Simeone , Wafa Frigui , Christine Laurent , et al.
Journal of Infectious Diseases, 2011, 203 (8), pp.1155-1164. ⟨10.1093/infdis/jiq089⟩
Journal articles pasteur-02862998v1

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

Daria Bottai , Mariagrazia Di Luca , Laleh Majlessi , Wafa Frigui , Roxane Simeone , et al.
Molecular Microbiology, 2012, 83 (6), pp.1195-1209. ⟨10.1111/j.1365-2958.2012.08001.x⟩
Journal articles pasteur-02615214v1

Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis

Roxane Simeone , Mathieu Léger , Patricia Constant , Wladimir Malaga , Hedia Marrakchi , et al.
FEBS Journal, 2010, 277 (12), pp.2715-2725. ⟨10.1111/j.1742-464X.2010.07688.x⟩
Journal articles pasteur-02862996v1
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Characterization of Mycobacterium orygis as M. tuberculosis Complex Subspecies

Jakko van Ingen , Zeaur Rahim , Arnout Mulder , Martin Boeree , Roxane Simeone , et al.
Emerging Infectious Diseases, 2012, 18 (4), pp.653-655. ⟨10.3201/eid1804.110888⟩
Journal articles pasteur-02863004v1

ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis

Jacques Augenstreich , Ainhoa Arbues , Roxane Simeone , Evert Haanappel , Alice Wegener , et al.
Cellular Microbiology, 2017, 19 (7), pp.e12726. ⟨10.1111/cmi.12726⟩
Journal articles hal-02326055v1

ESX secretion systems: mycobacterial evolution to counter host immunity

Matthias I Gröschel , Fadel Sayes , Roxane Simeone , Laleh Majlessi , Roland Brosch
Nature Reviews Microbiology, 2016, 14 (11), pp.677-691. ⟨10.1038/nrmicro.2016.131⟩
Journal articles hal-02640982v1

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protection

Roxane Simeone , Daria Bottai , Wafa Frigui , Laleh Majlessi , Roland Brosch
Tuberculosis, 2015, 95, pp.S150-S154. ⟨10.1016/⟩
Journal articles pasteur-02863008v1
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p62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways

Serge Mostowy , Vanessa Sancho-Shimizu , Mélanie Anne Hamon , Roxane Simeone , Roland Brosch , et al.
Journal of Biological Chemistry, 2011, 286 (30), pp.26987 - 26995. ⟨10.1074/jbc.M111.223610⟩
Journal articles hal-02651422v1
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The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

Christophe J Queval , Roland Brosch , Roxane Simeone
Frontiers in Microbiology, 2017, 8, pp.2284. ⟨10.3389/fmicb.2017.02284⟩
Journal articles pasteur-02046252v1
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Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

Philip Supply , Michael Marceau , Sophie Mangenot , David Roche , Carine Rouanet , et al.
Nature Genetics, 2013, 45 (2), pp.172-179. ⟨10.1038/ng.2517⟩
Journal articles pasteur-02615220v1

Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity

Meghan Kirksey , Anna Tischler , Roxane Simeone , Katherine Hisert , Swapna Uplekar , et al.
Infection and Immunity, 2011, 79 (7), pp.2829-2838. ⟨10.1128/IAI.00097-11⟩
Journal articles pasteur-02863001v1
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Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

Roxane Simeone , Alexandre Bobard , Juliane Lippmann , Wilbert Bitter , Laleh Majlessi , et al.
PLoS Pathogens, 2012, 8 (2), pp.e1002507. ⟨10.1371/journal.ppat.1002507⟩
Journal articles pasteur-01899479v1

Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

Stephen Gordon , Daria Bottai , Roxane Simeone , Timothy P Stinear , Roland Brosch
BioEssays, 2009, 31 (4), pp.378-388. ⟨10.1002/bies.200800191⟩
Journal articles istex pasteur-02862992v1
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Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection.

Matthias I Gröschel , Fadel Sayes , Sung Jae Shin , Wafa Frigui , Alexandre Pawlik , et al.
Cell Reports, 2017, 18 (11), pp.2752-2765. ⟨10.1016/j.celrep.2017.02.057⟩
Journal articles pasteur-01503927v1

ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells

Alessandra Romagnoli , Marilena Etna , Elena Giacomini , Manuela Pardini , Maria Elena Remoli , et al.
Autophagy, 2014, 8 (9), pp.1357-1370. ⟨10.4161/auto.20881⟩
Journal articles pasteur-02863005v1

Lipids of Pathogenic Mycobacteria: Contributions to Virulence and Host Immune Suppression

Laure Guenin-Macé , Roxane Simeone , Caroline Demangel
Transboundary and emerging diseases, 2009, 56 (6-7), pp.255-268. ⟨10.1111/j.1865-1682.2009.01072.x⟩
Journal articles istex pasteur-02863010v1
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Mycobacteria–host interactions in human bronchiolar airway organoids

Nino Iakobachvili , Stephen Adonai Leon‐icaza , Kèvin Knoops , Norman Sachs , Serge Mazères , et al.
Molecular Microbiology, 2022, 117 (3), pp.682-692. ⟨10.1111/mmi.14824⟩
Journal articles hal-03856942v1

Perspectives on mycobacterial vacuole-to-cytosol translocation: the importance of cytosolic access

Roxane Simeone , Laleh Majlessi , Jost Enninga , Roland Brosch
Cellular Microbiology, 2016, 18 (8), pp.1070 - 1077. ⟨10.1111/cmi.12622⟩
Journal articles pasteur-01899438v1

The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages

Anne-Laure Roux , Albertus Viljoen , Aicha Bah , Roxane Simeone , Audrey Bernut , et al.
Open Biology, 2016, 6 (11), ⟨10.1098/rsob.160185⟩
Journal articles hal-01438481v1
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Breaching the phagosome, the case of the tuberculosis agent

Roxane Simeone , Fadel Sayes , Emeline Lawarée , Roland Brosch
Cellular Microbiology, 2021, 23 (7), pp.e13344. ⟨10.1111/cmi.13344⟩
Journal articles pasteur-03413281v1

ESX/type VII secretion systems and their role in host–pathogen interaction

Roxane Simeone , Daria Bottai , Roland Brosch
Current Opinion in Microbiology, 2009, 12 (1), pp.4-10. ⟨10.1016/j.mib.2008.11.003⟩
Journal articles pasteur-02862977v1

Identification of the Missing trans-Acting Enoyl Reductase Required for Phthiocerol Dimycocerosate and Phenolglycolipid Biosynthesis in Mycobacterium tuberculosis

Roxane Simeone , Patricia Constant , Christophe Guilhot , Mamadou Daffé , Christian Chalut
Journal of Bacteriology, 2007, 189 (13), pp.4597-4602. ⟨10.1128/JB.00169-07⟩
Journal articles pasteur-02862990v1

Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential.

Fadel Sayes , Lin Sun , Mariagrazia Di Luca , Roxane Simeone , Nathalie Degaiffier , et al.
Cell Host and Microbe, 2012, 11 (4), pp.352-63. ⟨10.1016/j.chom.2012.03.003⟩
Journal articles pasteur-01104794v1