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Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors

Marian Flipo , Isabelle Florent , Philippe Grellier , Christian Sergheraert , Rebecca Déprez-Poulain
Bioorganic and Medicinal Chemistry Letters, 2003, 13 (16), pp.2659-2662. ⟨10.1016/S0960-894X(03)00550-X⟩
Journal articles mnhn-02867485v1

Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase PfA-M1 as Potential Antimalarial Agents

Marion Flipo , Terence Beghyn , Virginie Leroux , Isabelle Florent , Benoit Déprez , et al.
Journal of Medicinal Chemistry, 2007, 50 (6), pp.1322-1334. ⟨10.1021/jm061169b⟩
Journal articles istex mnhn-02904302v1

Synthesis of a 200-member library of squaric acid N-hydroxylamide amides.

Julie Charton , Benoît P. Déprez , Rébecca F. Déprez-Poulain
Bioorganic and Medicinal Chemistry Letters, 2008, 18 (18), pp.4968-71. ⟨10.1016/j.bmcl.2008.08.025⟩
Journal articles istex inserm-00323821v1

Chimie thérapeutique et chémobiologie.

Rebecca Déprez , Frédéric Schmidt , Brigitte Lesur
L'Actualité Chimique, 2021
Journal articles hal-03514288v1
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Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors

Rébecca F. Déprez-Poulain , Marion Flipo , Catherine Piveteau , Florence Leroux , Sandrine Dassonneville , et al.
Journal of Medicinal Chemistry, 2012, 55 (24), pp.10909-10917. ⟨10.1021/jm301506h⟩
Journal articles hal-03051765v1

Solvent-free microwave-assisted Meyers’ lactamization

Mouhamad Jida , Rebecca Deprez-Poulain , Sandra Malaquin , Pascal Roussel , Francine Agbossou-Niedercorn , et al.
Green Chemistry, 2010, 12, pp.961-964. ⟨10.1039/b924111f⟩
Journal articles istex hal-02269383v1
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Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening

Florence Leroux , Damien Bosc , Terence Beghyn , Paul Hermant , Sandrine Warenghem , et al.
European Journal of Medicinal Chemistry, 2019, 179, pp.557-566. ⟨10.1016/j.ejmech.2019.06.057⟩
Journal articles hal-03243182v1
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Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates

Alice Legru , Federica Verdirosa , Yen Vo-Hoang , Giusy Tassone , Filippo Vascon , et al.
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
Journal articles hal-03978634v1
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Rebecca Déprez-Poulain , Nathalie Hennuyer , Damien Bosc , Wenguang Liang , Emmanuelle Enée , et al.
Nature Communications, 2015, 6 (8250), ⟨10.1038/ncomms9250⟩
Journal articles hal-02511111v1

Synthesis, Antimalarial Activity, and Molecular Modeling of New Pyrrolo[1,2- a ]quinoxalines, Bispyrrolo[1,2- a ]quinoxalines, Bispyrido[3,2- e ]pyrrolo[1,2- a ]pyrazines, and Bispyrrolo[1,2- a ]thieno[3,2- e ]pyrazines

Jean Guillon , Philippe Grellier , Mehdi Labaied , Pascal Sonnet , Jean-Michel Léger , et al.
Journal of Medicinal Chemistry, 2004, 47 (8), pp.1997-2009. ⟨10.1021/jm0310840⟩
Journal articles istex mnhn-02867477v1
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Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds.

Julie Charton , Lise Charruault , Rebecca Déprez-Poulain , Benoit Déprez
Combinatorial Chemistry and High Throughput Screening, 2008, 11 (4), pp.294-303. ⟨10.2174/138620708784246013⟩
Journal articles inserm-00281198v1
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A simple reaction to produce small structurally complex and diverse molecules

Rebecca Deprez-Poulain , Nicolas Willand , Christophe Boutillon , Guy Nowogrocki , Nathalie Azaroual , et al.
Tetrahedron Letters, 2004, 45 (27), pp.5287-5290. ⟨10.1016/j.tetlet.2004.05.008⟩
Journal articles inserm-00110443v1

Discovery, Structure–Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5

Sylvain Picon , Rajaa Boulahjar , Vanessa Hoguet , Morgane Baron , Isabelle Duplan , et al.
Journal of Medicinal Chemistry, 2023, ⟨10.1021/acs.jmedchem.2c01881⟩
Journal articles hal-04192205v1
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Kinetic Target-Guided Synthesis: Reaching the Age of Maturity

Damien Bosc , Virgyl Camberlein , Ronan Gealageas , Omar Castillo-Aguilera , Benoit Deprez , et al.
Journal of Medicinal Chemistry, 2019, 63 (8), pp.3817-3833. ⟨10.1021/acs.jmedchem.9b01183⟩
Journal articles hal-03051818v1
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Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.

Julie Charton , Rebecca Deprez-Poulain , Nathalie Hennuyer , Anne Tailleux , Bart Staels , et al.
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (2), pp.489-92. ⟨10.1016/j.bmcl.2008.11.040⟩
Journal articles inserm-00360276v1

Identification of indole-based activators of insulin degrading enzyme

Nicolas Kraupner , Chau Phi Dinh , Xiaoan Wen , Valérie Landry , Adrien Herledan , et al.
European Journal of Medicinal Chemistry, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
Journal articles hal-03430475v1
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ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Florent Letronne , Geoffroy Laumet , Anne-Marie Ayral , Julien Chapuis , Florie Demiautte , et al.
EBioMedicine, 2016, 9, pp.278-292. ⟨10.1016/j.ebiom.2016.06.002⟩
Journal articles hal-02155738v1
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Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

Laetitia Lesire , Florence Leroux , Rebecca Déprez-Poulain , Benoit Deprez
Cells, 2022, 11 (7), pp.1228. ⟨10.3390/cells11071228⟩
Journal articles hal-03657094v1

Synthesis and in Vitro and in Vivo Antimalarial Activity of N 1 -(7-Chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine Derivatives

Adina Ryckebusch , Rebecca Déprez-Poulain , Louis Maes , Marie-Ange Debreu-Fontaine , Elisabeth Mouray , et al.
Journal of Medicinal Chemistry, 2003, 46 (4), pp.542-557. ⟨10.1021/jm020960r⟩
Journal articles istex mnhn-02867486v1
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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Paul Hermant , Damien Bosc , Catherine Piveteau , Ronan Gealageas , Baovy Lam , et al.
Journal of Medicinal Chemistry, 2017, 60 (21), pp.9067-9089. ⟨10.1021/acs.jmedchem.7b01444⟩
Journal articles hal-03054238v1
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Hydroxamates: Relationships between Structure and Plasma Stability

Marion Flipo , Julie Charton , Akila Hocine , Sandrine Dassonneville , Benoit Deprez , et al.
Journal of Medicinal Chemistry, 2009, 52 (21), pp.6790-6802. ⟨10.1021/jm900648x⟩
Journal articles hal-03051799v1
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Drug Target Engagement using coupled Cellular Thermal Shift Assay -acoustic Reverse Phase Protein Array

Adrien Herledan , Marine Andres , Aurore Lejeune-Dodge , Florence Leroux , Alexandre Biela , et al.
Slas Discovery, 2019, 25 (2), pp.207-214. ⟨10.1177/2472555219897256⟩
Journal articles hal-03051837v1
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Modulators of hERAP2 discovered by High-Throughput Screening

Laura Medve , Ronan Gealageas , Vy Lam Bao , Valentin Guillaume , Omar Castillo-Aguilera , et al.
European Journal of Medicinal Chemistry, 2020, 211, pp.113053. ⟨10.1016/j.ejmech.2020.113053⟩
Journal articles hal-03059990v1

A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening.

Marion Flipo , Terence Beghyn , Julie Charton , Virginie A. Leroux , Benoit Déprez , et al.
Bioorganic and Medicinal Chemistry, 2007, 15 (1), pp.63-76. ⟨10.1016/j.bmc.2006.10.010⟩
Journal articles istex inserm-00323832v1