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Molecular characterization of Netrin-1 and APP receptor binding: New leads to block the progression of senile plaques in Alzheimer's disease.

Franck Borel , Fanny Marzocca , Jean-Guy Delcros , Nicolas Rama , Patrick Mehlen et al.
Biochemical and Biophysical Research Communications, 2017, 488 (3), pp.466-470. ⟨10.1016/j.bbrc.2017.05.056⟩
Journal articles hal-01538747v1
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Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference

M. Grandin , P. Mathot , G. Devailly , Y. Bidet , Akram Ghantous et al.
EMBO Molecular Medicine, 2016, 8 (8), pp.863-877. ⟨10.15252/emmm.201505945⟩
Journal articles hal-01792610v1

Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas

Laura Broutier , Marion Creveaux , Jonathan Vial , Antonin Tortereau , Jean-Guy Delcros et al.
EMBO Molecular Medicine, 2016, 8 (2), pp.96--104. ⟨10.15252/emmm.201505480⟩
Journal articles hal-01269905v1

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

J. Fombonne , P.-A. Bissey , C. Guix , R. Sadoul , Chantal Thibert et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (26), pp.10510-10515. ⟨10.1073/pnas.1200094109⟩
Journal articles hal-03089105v1

DCC association with lipid rafts is required for netrin-1-mediated axon guidance.

Zoltán Hérincs , Véronique Corset , Nathalie Cahuzac , Céline Furne , Valérie Castellani et al.
Journal of Cell Science, 2005, 118 (Pt 8), pp.1687-92. ⟨10.1242/jcs.02296⟩
Journal articles hal-00180552v1

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease

Patricia R. Spilman , Veronique Corset , Olivia Gorostiza , Karen S. Poksay , Veronica Galvan et al.
Journal of Alzheimer's Disease, 2016, 52 (1), pp.223-242. ⟨10.3233/JAD-151046⟩
Journal articles hal-01800005v1

The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinase

Céline Guenebeaud , David Goldschneider , Marie Castets , Catherine Guix , Guillaume Chazot et al.
Molecular Cell, 2010, 40 (6), pp.863 - 876. ⟨10.1016/j.molcel.2010.11.021⟩
Journal articles hal-02664844v1

Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo.

Benoit Gibert , B. Eckel , V. Gonin , D. Goldschneider , J. Fombonne et al.
British Journal of Cancer, 2012, 107 (1), pp.63-70. ⟨10.1038/bjc.2012.188⟩
Journal articles hal-00749610v1
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Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity

Céline Delloye-Bourgeois , Benjamin Gibert , Nicolas Rama , Jean-Guy Delcros , Nicolas Gadot et al.
PLoS Biology, 2013, 11 (8), pp.e1001623. ⟨10.1371/journal.pbio.1001623⟩
Journal articles inserm-02130094v1
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Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

Simon Renders , Arthur Flohr Svendsen , Jasper Panten , Nicolas Rama , Maria Maryanovich et al.
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-020-20801-0⟩
Journal articles hal-03428982v1

NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors

Andrea Paradisi , Carine Maisse-Paradisi , Agnès Bernet , Marie-May Coissieux , Mauro Maccarrone et al.
Gastroenterology, 2008, 135 (4), pp.1248-1257. ⟨10.1053/j.gastro.2008.06.080⟩
Journal articles hal-01606730v1

Dependence receptors: from basic research to drug development.

Patrick Mehlen , Dale E Bredesen
Science Signaling, 2011, 4 (157), pp.mr2. ⟨10.1126/scisignal.2001521⟩
Journal articles hal-00850822v1
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Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.

Jaouhar Mourali , Alan Bénard , Filipe Calheiros Lourenço , Céline Monnet , Catherine Greenland et al.
Molecular and Cellular Biology, 2006, 26 (16), pp.6209-22. ⟨10.1128/MCB.01515-05⟩
Journal articles inserm-00111959v1

Dependence receptor TrkC is a putative colon cancer tumor suppressor

A.-L. Genevois , G. Ichim , M.-M. Coissieux , M.-P. Lambert , F. Lavial et al.
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (8), pp.3017-3022. ⟨10.1073/pnas.1212333110⟩
Journal articles hal-02360901v1

Neurotrophins and cell death

Gabriel Ichim , Servane Tauszig-Delamasure , Patrick Mehlen
Experimental Cell Research, 2012, 318 (11), pp.1221-1228. ⟨10.1016/j.yexcr.2012.03.006⟩
Journal articles hal-02360903v1

Hépatite C, EGFR, cirrhose et nétrine-1: Intérêt en hépatocarcinogenèse ?

Marie-Laure Plissonnier , Thomas Lahlali , Patrick Mehlen , Romain Parent
médecine/sciences, 2016, 32 (6-7), pp.566-568. ⟨10.1051/medsci/20163206013⟩
Journal articles hal-01800027v1

RGM and its receptor neogenin regulate neuronal survival.

E. Matsunaga , S. Tauszig-Delamasure , P.P. Monnier , B.K. Mueller , S.M. Strittmatter et al.
Nature Cell Biology, 2004, 6, pp.749-755. ⟨10.1038/ncb1157⟩
Journal articles istex hal-00080594v1

DCC constrains tumour progression via its dependence receptor activity.

Marie Castets , Laura Broutier , Yann Molin , Marie Brevet , Guillaume Chazot et al.
Nature, 2012, 482 (7386), pp.534-7. ⟨10.1038/nature10708⟩
Journal articles istex inserm-00721045v1

Dependence Receptors and Cancer: Addiction to Trophic Ligands

B. Gibert , Patrick Mehlen
Cancer Research, 2015, 75 (24), pp.5171-5175. ⟨10.1158/0008-5472.CAN-14-3652⟩
Journal articles hal-02463298v1
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Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis.

Jimena Bouzas-Rodriguez , Jorge Ruben Cabrera , Céline Delloye-Bourgeois , Gabriel Ichim , Jean-Guy Delcros et al.
Journal of Clinical Investigation, 2010, 120 (3), pp.850-8. ⟨10.1172/JCI41013⟩
Journal articles hal-00475272v1

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin‐1 interference

Mélodie Grandin , Pauline Mathot , Guillaume Devailly , Yannick Bidet , Akram Ghantous et al.
EMBO Molecular Medicine, 2016, 8 (8), pp.863-877. ⟨10.15252/emmm.201505945⟩
Journal articles hal-02956419v1

RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons.

Jorge R Cabrera , Jimena Bouzas-Rodriguez , Servane Tauszig-Delamasure , Patrick Mehlen
Journal of Biological Chemistry, 2011, 286 (16), pp.14628-38. ⟨10.1074/jbc.M110.195461⟩
Journal articles hal-00782733v1

Caspase cleavage of the transcription factor FLI-1 during preB leukemic cell death.

S. Sarrazin , Christelle Bonod-Bidaud , P. Remy , P. Mehlen , F. Morle et al.
BBA - Biochimica et Biophysica Acta, 2002, 1592, pp.123-127
Journal articles hal-00314491v1

Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity

Pei-Ju Sung , Nicolas Rama , Jeromine Imbach , Stephany Fiore , Benjamin Ducarouge et al.
Cancer Research, 2019, 79 (14), pp.3651-3661. ⟨10.1158/0008-5472.CAN-18-2952⟩
Journal articles hal-02323505v1
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Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer

Jennifer Wischhusen , Jean-Guy Delcros , Patrick Mehlen , Frédéric Padilla
Journées RITS 2015, Mar 2015, Dourdan, France. pp 150-151
Conference papers inserm-01155018v1

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Lorenzo Galluzzi , Stuart A. Aaronson , John Abrams , Emad S Alnemri , David W. Andrews et al.
Cell Death and Differentiation, 2009, 16 (8), pp.1093-107. ⟨10.1038/cdd.2009.44⟩
Journal articles inserm-00420382v1

Caspase cleavage of the transcription factor FLI-1 during preB leukemic cell death.

S. Sarrazin , Christelle Bonod-Bidaud , P. Remy , P. Mehlen , F. Morle et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2002, 1592 (2), pp.123-127
Journal articles hal-00146862v1
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The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex.

Frédéric Mille , Chantal Thibert , Joanna Fombonne , Nicolas Rama , Catherine Guix et al.
Nature Cell Biology, 2009, 11 (6), pp.739-46. ⟨10.1038/ncb1880⟩
Journal articles inserm-00405390v1
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Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

Frédéric Mille , Fabien Llambi , Catherine Guix , Céline Delloye-Bourgeois , Céline Guenebeaud et al.
Cell Death and Differentiation, 2009, 16 (10), pp.1344-51. ⟨10.1038/cdd.2009.75⟩
Journal articles inserm-00405392v1

Immune checkpoint inhibitor treatment of a first cancer is associated with a decreased incidence of second primary cancer

P. Heudel , S. Chabaud , D. Perol , A. Flechon , J. Fayette et al.
ESMO Open, 2021, 6 (1), pp.100044. ⟨10.1016/j.esmoop.2020.100044⟩
Journal articles hal-03808637v1