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Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway

Floriane Gibault , Fabrice Bailly , Mathieu Corvaisier , Mathilde Coevoet , Guillemette Huet et al.
ChemMedChem, 2017, 52nd International Conference on Medicinal Chemistry, 12 (12), pp.954-961. ⟨10.1002/cmdc.201700063⟩
Journal articles hal-02060557v1
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Antagonists of the adenosine A 2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity

Romain Duroux , Laurence Agouridas , Nicolas Renault , Jamal El Bakali , Christophe Furman et al.
European Journal of Medicinal Chemistry, 2018, 144, pp.151-163. ⟨10.1016/j.ejmech.2017.12.007⟩
Journal articles hal-02060715v1

Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline

Sandrine Delarue-Cochin , Philippe Grellier , L Maes , Elisabeth Mouray , Christian Sergheraert et al.
European Journal of Medicinal Chemistry, 2008, 43 (10), pp.2045-2055. ⟨10.1016/j.ejmech.2007.11.003⟩
Journal articles istex mnhn-02070092v1

Design, synthesis and antimalarial activity of a glyoxylylhydrazone library

Adina Ryckebusch , J-S Fruchart , L Cattiaux , P Rousselot-Paillet , V Leroux et al.
Bioorganic and Medicinal Chemistry Letters, 2004, 14 (17), pp.4439-4443. ⟨10.1016/j.bmcl.2004.06.056⟩
Journal articles istex mnhn-02070128v1

Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors

Manon Sturbaut , Fabrice Bailly , Mathilde Coevoet , Pasquale Sileo , Martine Pugniere et al.
European Journal of Medicinal Chemistry, 2021, 226, pp.113835. ⟨10.1016/j.ejmech.2021.113835⟩
Journal articles hal-03429462v1

Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus

Thibaut Vausselin , Karin Séron , Muriel Lavie , Ahmed Atef Mesalam , Matthieu Lemasson et al.
Journal of Virology, 2016, 90 (19), pp.8422-8434. ⟨10.1128/JVI.00404-16⟩
Journal articles hal-02060744v1
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Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine

Raphaël Bolteau , Florian Descamps , Mohamed Ettaoussi , Daniel H. Caignard , Philippe Delagrange et al.
European Journal of Medicinal Chemistry, 2020, 189, pp.112078. ⟨10.1016/j.ejmech.2020.112078⟩
Journal articles hal-03489716v1

A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration

Marie Tautou , Sabiha Eddarkaoui , Florian Descamps , Paul-Emmanuel Larchanché , Mélanie Dumoulin et al.
2021
Preprints, Working Papers, ... hal-03203349v1

Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands

Marion Donnier-Marechal , Pascal Carato , Delphine Le Broc , Christophe Furman , Patricia Melnyk et al.
European Journal of Medicinal Chemistry, 2014, ⟨10.1016/j.ejmech.2014.01.013⟩
Journal articles hal-02060851v1

6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands

Paul-Emmanuel Larchanche , Vincent Ultré , Delphine Le Broc , Céline Ballandonne , Christophe Furman et al.
European Journal of Medicinal Chemistry, 2015, 92, pp.807-817. ⟨10.1016/j.ejmech.2015.01.052⟩
Journal articles hal-01116521v1
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(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

Marouan Rami , Jean-Yves Winum , Claudiu T Supuran , Patricia Melnyk , Saïd Yous et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.224-229. ⟨10.1080/14756366.2018.1543292⟩
Journal articles hal-02060639v1
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MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis

Maxime Liberelle , Romain Magnez , Xavier Thuru , Yamina Bencheikh , Séverine Ravez et al.
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-53099-0⟩
Journal articles hal-02407901v1
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Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives

Elodie Landagaray , Mohamed Ettaoussi , Romain Duroux , J.A. Boutin , Daniel-Henri Caignard et al.
European Journal of Medicinal Chemistry, 2016, 109, pp.360-370. ⟨10.1016/j.ejmech.2015.12.047⟩
Journal articles hal-02060776v1
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Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure

Rajâa Boulahjar , Angela Rincon Arias , Raphaël Bolteau , Nicolas Renault , Mathilde Coevoet et al.
Bioorganic and Medicinal Chemistry, 2018, 26 (12), pp.3296-3307. ⟨10.1016/j.bmc.2018.04.057⟩
Journal articles hal-02060656v1
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New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Nicolas Sergeant , Valérie Vingtdeux , Sabiha Eddarkaoui , Marion Gay , Caroline Evrard et al.
Neurobiology of Disease, 2019, 129, pp.217-233. ⟨10.1016/j.nbd.2019.03.028⟩
Journal articles inserm-02350071v1
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Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists

Aurélie Hurtevent , Morgan Le Naour , Veronique Leclerc , Pascal Carato , Patricia Melnyk et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.524-538. ⟨10.1080/14756366.2020.1713771⟩
Journal articles hal-02464519v2
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A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Antoine Marchand , Alessia Sarchione , Panagiotis Athanasopoulos , Hélène Bauderlique-Le Roy , Liesel Goveas et al.
Cells, 2022, 11 (6), pp.1018. ⟨10.3390/cells11061018⟩
Journal articles inserm-03625821v1

Targeting Transcriptional Enhanced Associate Domains (TEADs)

Floriane Gibault , Manon Sturbaut , Fabrice Bailly , Patricia Melnyk , Philippe Cotelle et al.
Journal of Medicinal Chemistry, 2017, 61 (12), pp.5057-5072. ⟨10.1021/acs.jmedchem.7b00879⟩
Journal articles hal-02060724v1
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Synthesis and switching properties of new derivatives of azoresveratrol

Jérôme Berthet , Laurence Agouridas , Siyao Chen , Hassan Allouchi , Patricia Melnyk et al.
Dyes and Pigments, 2019, 171, pp.107666 -. ⟨10.1016/j.dyepig.2019.107666⟩
Journal articles hal-03484526v1

La chimie en Région Hauts-de-France : Chimie, biologie et santé

Stéphane Lebrun , Philippe Amouyel , Christophe Biot , Véronique Bonnet , Benoît Déprez et al.
L'Actualité Chimique, 2017, 46-51 ; http://www.lactualitechimique.org/Chimie-biologie-et-sante
Journal articles hal-03834033v1

Synthèse de nouveaux dérivés tétrahydroquinoléine-hydantoïne, ligands des récepteurs sigma-1

Marion Toussaint , Amaury Cazenave Gassiot , Julie Charton , Patricia Melnyk
20èmes Journées Franco-Belges de Pharmacochimie, 2006, Lille, France
Conference papers hal-00101249v1

Nouvelles molécules interagissant sur le métabolisme de l'APP

Stéphane Burlet , Marie Eve Grosjean , Vanessa Willame , Bénédicte Grasland , Antoine Ghestem et al.
RECOB11, 2006, Aussois, France
Conference papers hal-00101257v1

Synthesis and antimalarial activity of new analogues of amodiaquine

Sandrine Delarue-Cochin , E Paunescu , L Maes , Elisabeth Mouray , Christian Sergheraert et al.
European Journal of Medicinal Chemistry, 2008, 43 (2), pp.252-260. ⟨10.1016/j.ejmech.2007.03.008⟩
Journal articles istex mnhn-02070095v1

Conception, synthèse de nouveaux inhibiteurs du récepteur Met

Alexandre Barras , Catherine Leroy , Nicole Dupont , Dragos Horvath , Véronique Fafeur et al.
Journées Jeunes Chercheurs SFC Nord, 2006, Villeneuve d'Ascq, France
Conference papers hal-00101283v1

Similar Structure Activity Relationships of Quinoline Derivatives for antiprion and antimalarial effects

Ralf Klingenstein , Patricia Melnyk , S. Rutger Leliveld , Adina Ryckebusch , Carsten Korth et al.
Journal of Medicinal Chemistry, 2006, 49 (17), pp.5300-5308. ⟨10.1021/jm0602763⟩
Journal articles istex hal-00098660v1
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Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Caroline Evrard , Pascal Kieulen-Campard , Mathilde Coevoet , Rémi Opsomer , Bernadette Tasiaux et al.
Frontiers in Cellular Neuroscience, 2018, 12, pp.435. ⟨10.3389/fncel.2018.00435⟩
Journal articles hal-02060617v1

Non-photoinduced biological properties of Verteporfin

Floriane Gibault , Mathieu Corvaisier , Fabrice Bailly , Guillemette Huet , Patricia Melnyk et al.
Current Medicinal Chemistry, 2016
Journal articles hal-02060761v1
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Evaluation of three neutral capillary coatings for the determination of analyte-cyclodextrin binding constants by affinity capillary electrophoresis. Application to N,N'-disubstituted piperazine derivatives.

Cécile Danel , Patricia Melnyk , Nathalie Azaroual , Paul-Emmanuel Larchanché , Jean-Francois Goossens et al.
Journal of Chromatography A, 2016, 1455, pp.163-171. ⟨10.1016/j.chroma.2016.05.090⟩
Journal articles hal-02060749v1
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A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

Marie Tautou , Sabiha Eddarkaoui , Florian Descamps , Paul-Emmanuel Larchanché , Jamal El Bakali et al.
Frontiers in Pharmacology, 2021, 12, pp.679335. ⟨10.3389/fphar.2021.679335⟩
Journal articles inserm-03366685v1
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Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

Valeria Moas Heloire , Nicolas Renault , Vânia Batalha , Angela Rincon Arias , Mathieu Marchivie et al.
European Journal of Medicinal Chemistry, 2015, 106, pp.15-25. ⟨10.1016/j.ejmech.2015.10.030⟩
Journal articles hal-02060788v1