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Utilisation de dérivés peptidiques (peptides et pseudo-peptides), qui présentent une affinité pour des récepteurs/transporteurs cellulaires, des types cellulaires particuliers et/ou qui passent les membranes cellulaires notamment celles des barrières physiologiques du cerveau telle que la barrière hémato-encéphalique (BHE), comme vecteurs de molécules d'intérêt thérapeutique ou d'agents d'imagerie ou de diagnostic ou de toute autre molécule comme une sonde moléculaire
Michel Khrestchatisky
,
Société Vect-Horus
N° de brevet: En cours. 2009
Patents
hal-00321258v1
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Identification of LRP-1 as an endocytosis and recycling receptor for B1-integrin in thyroid cancer cells
Louis Theret
,
Albin Jeanne
,
Benoît Langlois
,
Cathy Hachet
,
Marion David
et al.
Journal articles
hal-02184520v1
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to neuroinflammation following pilocarpine‐induced seizures in rats
Grigorios Kyriatzis
,
Anne Bernard
,
Angélique Bôle
,
Guillaume Pflieger
,
Petros Chalas
et al.
Journal articles
hal-03452666v1
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Cholecalciferol (vitamin D-3) improves functional recovery when delivered during the acute phase after a spinal cord trauma
Yatma Gueye
,
Tanguy Marqueste
,
Fanny Maurel
,
Michel Khrestchatisky
,
Patrick Decherchi
et al.
Journal articles
hal-01414098v1
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Grafts of olfactory stem cells restore breathing and motor functions after a rat spinal cord injury
Jean-Claude Stamegna
,
Kevin Sadelli
,
Guy Escoffier
,
Stéphane D. Girard
,
Antoine D. Veron
et al.
Journal articles
hal-01718177v1
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Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.
Yves Molino
,
Marion David
,
Karine Varini
,
Françoise Jabès
,
Nicolas Gaudin
et al.
FASEB Journal, 2017
Journal articles
hal-01478978v1
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to status epilepticus and neuroinflammation following pilocarpine administration in rats
Kyriatzis Grigorios
,
Bernard Anne
,
Bôle Angélique
,
Pflieger Guillaume
,
Chalas Petros
et al.
2020
Preprints, Working Papers, ...
hal-03073954v1
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Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies
K. Varini
,
P. Lécorché
,
R. Sonnette
,
F. Gassiot
,
B. Broc
et al.
Journal articles
hal-02348680v1
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Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking
Jean-Michel Paumier
,
Nathalie Py
,
Laura García-González
,
Anne Bernard
,
Delphine Stephan
et al.
Journal articles
hal-02387988v1
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Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation.
Anne Bernard
,
Lotfi Ferhat
,
Frédéric Dessi
,
Gérard Charton
,
Alfonso Represa
et al.
European Journal of Neuroscience, 1999, 11 (2), pp.604-16
Journal articles
inserm-00487253v1
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Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury
Jean-Francois Chabas
,
Delphine Stephan
,
Tanguy Marqueste
,
Stephane Garcia
,
Marie-Noelle Lavaut
et al.
Journal articles
hal-01718197v1
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Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery
Patrick Vlieghe
,
Michel Khrestchatisky
Journal articles
istex
hal-01718195v1
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The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties
Bruno Delorme
,
Emmanuel Nivet
,
Julien Gaillard
,
Thomas Häupl
,
Jochen Ringe
et al.
Journal articles
hal-01736210v1
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The FVB/N mice: A well suited strain to study learning and memory ă processes using olfactory cues
Stephane D. Girard
,
Guy Escoffier
,
Michel Khrestchatisky
,
Francois S. Roman
Journal articles
hal-01477821v1
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Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos
Marion David
,
Pascaline Lecorché
,
Maxime Masse
,
Aude Faucon
,
Karima Abouzid
et al.
Journal articles
hal-01765841v1
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Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP
Nathalie A. Py
,
Amandine E. Bonnet
,
Anne Bernard
,
Yannick Marchalant
,
Eliane Charrat
et al.
Journal articles
hal-01718189v1
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Dérivés peptidiques et leur utilistion comme vecteurs de molécules sous forme de conjugués
Michel Khrestchatisky
,
Marion David
,
Yves Molino
,
Anne Fourtoul
,
Patrick Vlieghe
et al.
France, Patent n° : FR 08 57159. 2008
Patents
hal-00342607v1
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The Human Nose Harbors a Niche of Olfactory Ectomesenchymal Stem Cells Displaying Neurogenic and Osteogenic Properties
Bruno Delorme
,
Emmanuel Nivet
,
Julien Gaillard
,
Thomas Häupl
,
Jochen Ringe
et al.
Journal articles
hal-02373958v1
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Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.
M Cardoso
,
S Timsit
,
L Villard
,
Michel Khrestchatisky
,
M Fontès
et al.
Human Molecular Genetics, 1998, 7 (4), pp.679-84
Journal articles
hal-02090196v1
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Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.
Emilie Cornille
,
Mhamad Abou-Hamdan
,
Michel Khrestchatisky
,
André Nieoullon
,
Max de Reggi
et al.
Journal articles
hal-00848881v1
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Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse Model
Kévin Baranger
,
Manuel van Gijsel-Bonnello
,
Delphine Stephan
,
Wassila Carpentier
,
Santiago Rivera
et al.
Journal articles
hal-02339537v1
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MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro
Kévin Baranger
,
Amandine E Bonnet
,
Stéphane D Girard
,
Michel Paumier
,
Laura García-González
et al.
Journal articles
hal-01479008v1
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Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease
Stéphane D. Girard
,
Marlyse Jacquet
,
Kévin Baranger
,
Martine Migliorati
,
Guy Escoffier
et al.
Journal articles
istex
hal-01718190v1
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A unique method for the isolation of nasal olfactory stem cells in living rats
Jean-Claude Stamegna
,
Stéphane D. Girard
,
Antoine Veron
,
Gilles Sicard
,
Michel Khrestchatisky
et al.
Journal articles
hal-01718191v1
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Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal ă cord-derived microvascular endothelial cells
Yves Molino
,
Francoise Jabes
,
Amandine Bonnet
,
Nicolas Gaudin
,
Anne Bernard
et al.
Journal articles
hal-01477828v1
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MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?
Kévin Baranger
,
Michel Khrestchatisky
,
Santiago Rivera
Journal articles
hal-01477833v1
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Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?
Serge Timsit
,
Santiago Rivera
,
Philippe Ouaghi
,
Frédérique Guischard
,
Evelyne Tremblay
et al.
European Journal of Neuroscience, 1999, 11 (1), pp.263-78
Journal articles
inserm-00486281v1
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High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis
Adil Maarouf
,
Delphine Stephan
,
Marie-Pierre Ranjeva
,
Jean-Philippe Ranjeva
,
Jean Pelletier
et al.
Journal articles
hal-02059493v1
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Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders
F. Feron
,
B Gepner
,
E Lacassagne
,
D Stephan
,
B Mesnage
et al.
Journal articles
hal-01787249v1
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Developmental vitamin D deficiency alters learning in C57Bl/6J mice
Diana Andrea Fernandes De Abreu
,
Emmanuel Nivet
,
Nathalie Baril
,
Michel Khrestchatisky
,
François Roman
et al.
Journal articles
hal-01736211v1
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