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Utilisation de dérivés peptidiques (peptides et pseudo-peptides), qui présentent une affinité pour des récepteurs/transporteurs cellulaires, des types cellulaires particuliers et/ou qui passent les membranes cellulaires notamment celles des barrières physiologiques du cerveau telle que la barrière hémato-encéphalique (BHE), comme vecteurs de molécules d'intérêt thérapeutique ou d'agents d'imagerie ou de diagnostic ou de toute autre molécule comme une sonde moléculaire

Michel Khrestchatisky , Société Vect-Horus
N° de brevet: En cours. 2009
Patents hal-00321258v1

Identification of LRP-1 as an endocytosis and recycling receptor for B1-integrin in thyroid cancer cells

Louis Theret , Albin Jeanne , Benoît Langlois , Cathy Hachet , Marion David et al.
Oncotarget, 2017, 8 (45), pp.78614-78632. ⟨10.18632/oncotarget.20201⟩
Journal articles hal-02184520v1
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to neuroinflammation following pilocarpine‐induced seizures in rats

Grigorios Kyriatzis , Anne Bernard , Angélique Bôle , Guillaume Pflieger , Petros Chalas et al.
Glia, 2021, 69 (11), pp.2618 - 2643. ⟨10.1002/glia.24062⟩
Journal articles hal-03452666v1

Cholecalciferol (vitamin D-3) improves functional recovery when delivered during the acute phase after a spinal cord trauma

Yatma Gueye , Tanguy Marqueste , Fanny Maurel , Michel Khrestchatisky , Patrick Decherchi et al.
Journal of Steroid Biochemistry and Molecular Biology, 2015, 154, pp.23-31. ⟨10.1016/j.jsbmb.2015.06.007⟩
Journal articles hal-01414098v1

Grafts of olfactory stem cells restore breathing and motor functions after a rat spinal cord injury

Jean-Claude Stamegna , Kevin Sadelli , Guy Escoffier , Stéphane D. Girard , Antoine D. Veron et al.
Journal of Neurotrauma, 2018, ⟨10.1089/neu.2017.5383⟩
Journal articles hal-01718177v1

Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.

Yves Molino , Marion David , Karine Varini , Françoise Jabès , Nicolas Gaudin et al.
FASEB Journal, 2017
Journal articles hal-01478978v1
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Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to status epilepticus and neuroinflammation following pilocarpine administration in rats

Kyriatzis Grigorios , Bernard Anne , Bôle Angélique , Pflieger Guillaume , Chalas Petros et al.
2020
Preprints, Working Papers, ... hal-03073954v1

Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies

K. Varini , P. Lécorché , R. Sonnette , F. Gassiot , B. Broc et al.
Journal of Controlled Release, 2019, 314, pp.141-161. ⟨10.1016/j.jconrel.2019.10.033⟩
Journal articles hal-02348680v1

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking

Jean-Michel Paumier , Nathalie Py , Laura García-González , Anne Bernard , Delphine Stephan et al.
FASEB Journal, 2019, 33 (2), pp.2910-2927. ⟨10.1096/fj.201801076R⟩
Journal articles hal-02387988v1
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Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation.

Anne Bernard , Lotfi Ferhat , Frédéric Dessi , Gérard Charton , Alfonso Represa et al.
European Journal of Neuroscience, 1999, 11 (2), pp.604-16
Journal articles inserm-00487253v1
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Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury

Jean-Francois Chabas , Delphine Stephan , Tanguy Marqueste , Stephane Garcia , Marie-Noelle Lavaut et al.
PLoS ONE, 2013, 8 (5), pp.e65034. ⟨10.1371/journal.pone.0065034⟩
Journal articles hal-01718197v1

Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery

Patrick Vlieghe , Michel Khrestchatisky
Medicinal Research Reviews, 2013, 33 (3), pp.457--516. ⟨10.1002/med.21252⟩
Journal articles istex hal-01718195v1

The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties

Bruno Delorme , Emmanuel Nivet , Julien Gaillard , Thomas Häupl , Jochen Ringe et al.
Stem Cells and Development, 2010, 19 (6), pp.853--866. ⟨10.1089/scd.2009.0267⟩
Journal articles hal-01736210v1

The FVB/N mice: A well suited strain to study learning and memory ă processes using olfactory cues

Stephane D. Girard , Guy Escoffier , Michel Khrestchatisky , Francois S. Roman
Behavioural Brain Research, 2016, 296, pp.254-259. ⟨10.1016/j.bbr.2015.09.004⟩
Journal articles hal-01477821v1
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Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos

Marion David , Pascaline Lecorché , Maxime Masse , Aude Faucon , Karima Abouzid et al.
PLoS ONE, 2018, 13 (2), pp.e0191052. ⟨10.1371/journal.pone.0191052⟩
Journal articles hal-01765841v1
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Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP

Nathalie A. Py , Amandine E. Bonnet , Anne Bernard , Yannick Marchalant , Eliane Charrat et al.
Frontiers in Aging Neuroscience, 2014, 6, pp.247. ⟨10.3389/fnagi.2014.00247⟩
Journal articles hal-01718189v1

Dérivés peptidiques et leur utilistion comme vecteurs de molécules sous forme de conjugués

Michel Khrestchatisky , Marion David , Yves Molino , Anne Fourtoul , Patrick Vlieghe et al.
France, Patent n° : FR 08 57159. 2008
Patents hal-00342607v1

The Human Nose Harbors a Niche of Olfactory Ectomesenchymal Stem Cells Displaying Neurogenic and Osteogenic Properties

Bruno Delorme , Emmanuel Nivet , Julien Gaillard , Thomas Häupl , Jochen Ringe et al.
Stem Cells and Development, 2010, 19 (6), pp.853-866. ⟨10.1089/scd.2009.0267⟩
Journal articles hal-02373958v1

Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.

M Cardoso , S Timsit , L Villard , Michel Khrestchatisky , M Fontès et al.
Human Molecular Genetics, 1998, 7 (4), pp.679-84
Journal articles hal-02090196v1

Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.

Emilie Cornille , Mhamad Abou-Hamdan , Michel Khrestchatisky , André Nieoullon , Max de Reggi et al.
BMC Neuroscience, 2010, 11, pp.51. ⟨10.1186/1471-2202-11-51⟩
Journal articles hal-00848881v1
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Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse Model

Kévin Baranger , Manuel van Gijsel-Bonnello , Delphine Stephan , Wassila Carpentier , Santiago Rivera et al.
Neurotherapeutics, 2019, ⟨10.1007/s13311-019-00754-z⟩
Journal articles hal-02339537v1
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MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

Kévin Baranger , Amandine E Bonnet , Stéphane D Girard , Michel Paumier , Laura García-González et al.
Frontiers in Molecular Neuroscience, 2017, 9, pp.163. ⟨10.3389/fnmol.2016.00163⟩
Journal articles hal-01479008v1

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease

Stéphane D. Girard , Marlyse Jacquet , Kévin Baranger , Martine Migliorati , Guy Escoffier et al.
Hippocampus, 2014, 24 (7), pp.762--772. ⟨10.1002/hipo.22267⟩
Journal articles istex hal-01718190v1

A unique method for the isolation of nasal olfactory stem cells in living rats

Jean-Claude Stamegna , Stéphane D. Girard , Antoine Veron , Gilles Sicard , Michel Khrestchatisky et al.
Stem Cell Research, 2014, 12 (3), pp.673--679. ⟨10.1016/j.scr.2014.02.010⟩
Journal articles hal-01718191v1
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Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal ă cord-derived microvascular endothelial cells

Yves Molino , Francoise Jabes , Amandine Bonnet , Nicolas Gaudin , Anne Bernard et al.
Journal of Neuroinflammation, 2016, 13 (1), pp.290. ⟨10.1186/s12974-016-0749-6⟩
Journal articles hal-01477828v1

MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?

Kévin Baranger , Michel Khrestchatisky , Santiago Rivera
Journal of Neuroinflammation, 2016, 13, ⟨10.1186/s12974-016-0633-4⟩
Journal articles hal-01477833v1
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Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

Serge Timsit , Santiago Rivera , Philippe Ouaghi , Frédérique Guischard , Evelyne Tremblay et al.
European Journal of Neuroscience, 1999, 11 (1), pp.263-78
Journal articles inserm-00486281v1
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High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis

Adil Maarouf , Delphine Stephan , Marie-Pierre Ranjeva , Jean-Philippe Ranjeva , Jean Pelletier et al.
Journal of Translational Medicine, 2019, 17 (1), ⟨10.1186/s12967-019-1789-3⟩
Journal articles hal-02059493v1
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Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders

F. Feron , B Gepner , E Lacassagne , D Stephan , B Mesnage et al.
Molecular Psychiatry, 2016, 21 (9), pp.1215 - 1224. ⟨10.1038/mp.2015.106⟩
Journal articles hal-01787249v1

Developmental vitamin D deficiency alters learning in C57Bl/6J mice

Diana Andrea Fernandes De Abreu , Emmanuel Nivet , Nathalie Baril , Michel Khrestchatisky , François Roman et al.
Behavioural Brain Research, 2010, 208 (2), pp.603--608. ⟨10.1016/j.bbr.2010.01.005⟩
Journal articles hal-01736211v1