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Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

Luise Schultz , Marie-Gabrielle Zurich , Maxime Culot , Anaelle da Costa , Christophe Landry et al.
Toxicology in Vitro, 2015, 30 (1), pp.138-165. ⟨10.1016/j.tiv.2015.05.016⟩
Journal articles hal-02513335v1
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An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat

Carolina Nunes , Pranika Singh , Zahra Mazidi , Cormac Murphy , Aurore Bourguignon et al.
Toxicology in Vitro, 2022, 81, pp.105333. ⟨10.1016/j.tiv.2022.105333⟩
Journal articles hal-03706955v1

Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood–brain barrier

P. Bellwon , M. Culot , A. Wilmes , T. Schmidt , M.G. Zurich et al.
Toxicology in Vitro, 2015, 30 (1), pp.166-175. ⟨10.1016/j.tiv.2015.01.003⟩
Journal articles hal-02513358v1

Accelerated Caco-2 cell permeability model for drug discovery

Emmanuel Sevin , L. Dehouck , A. Fabulas-da Costa , R. Cecchelli , M.P. Dehouck et al.
Journal of Pharmacological and Toxicological Methods, 2013, 68 (3), pp.334-339. ⟨10.1016/j.vascn.2013.07.004⟩
Journal articles hal-02515314v1

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

Roméo Cecchelli , Sezin Aday , Emmanuel Sevin , Catarina Almeida , Maxime Culot et al.
PLoS ONE, 2014, 9 (6), pp.e99733. ⟨10.1371/journal.pone.0099733⟩
Journal articles hal-02515233v1
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Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model

Ana R Santa-Maria , Fruzsina R Walter , Ricardo Figueiredo , András Kincses , Judith Vigh et al.
Journal of Cerebral Blood Flow and Metabolism, 2021, 41 (9), pp.2201-2215. ⟨10.1177/0271678X21992638⟩
Journal articles hal-03185580v1
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Challenges and opportunities in the use of transcriptomics characterization for human iPSC-derived BBB models

Sara Wellens , Fabien Gosselet , Maxime Culot
Toxicology in Vitro, In press, ⟨10.1016/j.tiv.2022.105424⟩
Journal articles hal-03708257v1

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

Elke de Vuyst , Nan Wang , Elke Decrock , Marijke de Bock , Mathieu Vinken et al.
Cell Calcium, 2009, 46, p. 176-187
Journal articles hal-00544068v1

Blood–Brain Barrier In Vitro Models and Their Applications in Toxicology

Anaelle Fabulas-da Costa , Christophe Landry , Lucie Dehouck , Emmanuel Sevin , Marie-Pierre Dehouck et al.
In Vitro Toxicology Systems. Methods in Pharmacology and Toxicology, Humana Press, pp.147-166, 2014, 978-1-4939-0520-1. ⟨10.1007/978-1-4939-0521-8_7⟩
Book sections hal-02504329v1

Endothelial calcium dynamics, connexin channels and blood–brain barrier function

Marijke de Bock , Nan Wang , Elke Decrock , Mélissa Bol , Ashish Gadicherla et al.
Progress in Neurobiology, 2013, 108, pp.1-20. ⟨10.1016/j.pneurobio.2013.06.001⟩
Journal articles hal-02515498v1
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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Manuel Lasalle , Vanessa Hoguet , Nathalie Hennuyer , Florence Leroux , Catherine Piveteau et al.
Journal of Medicinal Chemistry, 2017, 60 (10), pp.4185-4211. ⟨10.1021/acs.jmedchem.6b01873⟩
Journal articles inserm-02115415v1
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Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen

Emma E.J. Kasteel , Leonie S. Lautz , Maxime Culot , Nynke I Kramer , Anne Zwartsen et al.
Toxicology in Vitro, 2021, 76, pp.105223. ⟨10.1016/j.tiv.2021.105223⟩
Journal articles anses-03317990v1

A snapshot on the progress of in vitro toxicology for safety assessment

Paul Jennings , Raffaella Corvi , Maxime Culot
Toxicology in Vitro, 2017, 45, pp.269-271. ⟨10.1016/j.tiv.2017.10.024⟩
Journal articles hal-02506575v1
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HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator.

Benoit D Roussel , Caroline Mysiorek , Ari Rouhiainen , Amandine Jullienne , Jerome Parcq et al.
Journal of Cell Science, 2011, 124 (Pt 12), pp.2070-6. ⟨10.1242/jcs.084392⟩
Journal articles inserm-01296803v1

Peroxisome proliferator-activated receptor-α activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier

Caroline Mysiorek , Maxime Culot , Lucie Dehouck , Bruno Derudas , Bart Staels et al.
Current Neurovascular Research, 2009, 6 (3), pp.181-193. ⟨10.2174/156720209788970081⟩
Journal articles hal-00544019v1
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Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

Liadys Mora Lagares , Nikola Minovski , Ana Yisel Caballero Alfonso , Emilio Benfenati , Sara Wellens et al.
International Journal of Molecular Sciences, 2020, 21 (11), pp.4058. ⟨10.3390/ijms21114058⟩
Journal articles hal-03127238v1
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Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration

Marjolein Heymans , Emmanuel Sevin , Fabien Gosselet , Stefan Lundquist , Maxime Culot et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2018, 127, pp.453-461. ⟨10.1016/j.ejpb.2018.03.007⟩
Journal articles hal-02506299v1

Development and validation of a LC–MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood–brain barrier models

Evelyn Jähne , Daniela Eigenmann , Maxime Culot , Roméo Cecchelli , Fruzsina Walter et al.
Journal of Pharmaceutical and Biomedical Analysis, 2014, 98, pp.235-246. ⟨10.1016/j.jpba.2014.05.026⟩
Journal articles hal-02515229v1

A new angle on blood-CNS interfaces: A role for connexins?

Marijke de Bock , Roosmarijn Vandenbroucke , Elke Decrock , Maxime Culot , Roméo Cecchelli et al.
FEBS Letters, 2014, 588 (8), pp.1259-1270. ⟨10.1016/j.febslet.2014.02.060⟩
Journal articles hal-02515256v1
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A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters

Emmanuel Sevin , Lucie Dehouck , Romain Versele , Maxime Culot , Fabien Gosselet et al.
International Journal of Molecular Sciences, 2019, 20, ⟨10.3390/ijms20225529⟩
Journal articles hal-03282234v1
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Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier

Elisabet Sjöström , Maxime Culot , Lisa Leickt , Mikael Åstrand , Erik Nordling et al.
Brain, Behavior & Immunity - Health, 2021, 16, pp.100307. ⟨10.1016/j.bbih.2021.100307⟩
Journal articles hal-03472272v1
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Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Marjolein Heymans , Ricardo Figueiredo , Lucie Dehouck , David Francisco , Yasuteru Sano et al.
Fluids and Barriers of the CNS, 2020, 17 (1), ⟨10.1186/s12987-020-00208-1⟩
Journal articles hal-03127036v1

New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment

Dorothée Hallier-Vanuxeem , Pilar Prieto , Maxime Culot , Heidi Diallo , Christophe Landry et al.
Toxicology in Vitro, 2009, 23, p. 447-453
Journal articles hal-00527935v1

An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

Maxime Culot , Stefan Lundquist , Dorothée Vanuxeem , Stéphane Nion , Christophe Landry et al.
Toxicology in Vitro, 2008, 22, p. 799-811
Journal articles hal-00527560v1
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Central nervous system delivery of molecules across the blood-brain barrier

Fabien Gosselet , Rodrigo Azevedo Loiola , Anna Roig , Anna Rosell , Maxime Culot et al.
Neurochemistry International, 2021, 144, ⟨10.1016/j.neuint.2020.104952⟩
Journal articles hal-03282235v1

Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study

Maxime Culot , Caroline Mysiorek , Mila Renftel , Benoit D. Roussel , Yannick Hommet et al.
Brain Research, 2009, 1294, p. 144-152
Journal articles hal-00544037v1
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In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs

Daniela Elisabeth Eigenmann , Carmen Dürig , Evelyn Andrea Jähne , Martin Smieško , Maxime Culot et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2016, 103, pp.118-126. ⟨10.1016/j.ejpb.2016.03.029⟩
Journal articles hal-02510088v1

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor

Vanessa Hoguet , Manuel Lasalle , Mathieu Maingot , Geoffroy Dequirez , Rajaa Boulahjar et al.
Journal of Medicinal Chemistry, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩
Journal articles hal-03185533v1
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Rebecca Déprez-Poulain , Nathalie Hennuyer , Damien Bosc , Wenguang Liang , Emmanuelle Enée et al.
Nature Communications, 2015, 6 (8250), ⟨10.1038/ncomms9250⟩
Journal articles hal-02511111v1

Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin

Evelyn Jähne , Daniela Eigenmann , Chethan Sampath , Veronika Butterweck , Maxime Culot et al.
Planta Medica, 2016, 82 (11/12), pp.1021-1029. ⟨10.1055/s-0042-105295⟩
Journal articles hal-02506889v1