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Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase

Emilie da Costa Branquinho , Guillaume Becker , Cédric Bouteiller , Ludovic Jean , Pierre-Yves Renard , et al.
Nuclear Medicine and Biology, 2013, 40 (4), pp.554-560. ⟨10.1016/j.nucmedbio.2013.02.004⟩
Journal articles hal-00847401v1

Novel centrally active antidote for intoxication by sarin and VX nerve agents

T. Zorbaz , M. Katalinic , A. Zandona , Anissa Braïki , Ludovic Jean , et al.
Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back (42, 2017), Sep 2017, Jérusalem, Israel. pp.242, ⟨10.1111/febs.14174⟩
Conference papers hal-02024992v1

Synthesis and evaluations of uncharged reactivators for cholinesterases inhibited by organophosphate agents

Anissa Braïki , Julien Renou , Romain Mougeot , Florian Nachon , André-Guilhem Calas , et al.
International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (3, 2019), May 2019, Nantes, France
Poster communications hal-02543439v1

Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor

Monika Cieslikiewicz-Bouet , Marina Naldi , Manuela Bartolini , Belén Pérez , Denis Servent , et al.
Biochemical Pharmacology, 2020, 177, ⟨10.1016/j.bcp.2020.114010⟩
Journal articles hal-02560260v1

Screening of chiral phosphines as catalysts for the enantioselective (3+2) annulations of N-tosylimines with allenic esters

N. Fleury-Brégeot , Ludovic Jean , P. Retailleau , A. Marinetti
Tetrahedron, 2007, 63 (48), pp.11920-11927. ⟨10.1016/j.tet.2007.09.022⟩
Journal articles istex hal-00221434v1

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Elisabet Viayna , Nicolas Coquelle , Monika Cieslikiewicz-Bouet , Pedro Cisternas , Carolina Oliva , et al.
Journal of Medicinal Chemistry, 2020, ⟨10.1021/acs.jmedchem.0c01775⟩
Journal articles hal-03094189v1

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

Maria Kliachyna , Gianluca Santoni , Valentin Nussbaum , Julien Renou , Benoît Sanson , et al.
European Journal of Medicinal Chemistry, 2014, 78, pp.455-467. ⟨10.1016/j.ejmech.2014.03.044⟩
Journal articles hal-01131268v1

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1

Lucie Aliouane , Sovy Chao , Brizuela Leyre , Emmanuel Pfund , Cuvillier Olivier , et al.
Bioorganic and Medicinal Chemistry, 2014, 22 (17), pp.4955-4960. ⟨10.1016/j.bmc.2014.06.038⟩
Journal articles hal-01063240v1

Design, biological evaluation and X-ray crystallography of multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Ludovic Jean
Société de Chimie Thérapeutique - Young Research Fellows Meeting (YRFM, 27, 2020), Jan 2020, Caen, France
Conference papers hal-02544418v1

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.

Cyril Ronco , Eugénie Carletti , Jacques-Philippe Colletier , Martin Weik , Florian Nachon , et al.
ChemMedChem, 2012, 7 (3), pp.400-405. ⟨10.1002/cmdc.201100438⟩
Journal articles istex hal-00996475v1

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.

Xavier Brazzolotto , Marielle Wandhammer , Cyril Ronco , Marie Trovaslet , Ludovic Jean , et al.
FEBS Journal, 2012, 279 (16), pp.2905-2916. ⟨10.1111/j.1742-4658.2012.08672.x⟩
Journal articles hal-00996490v1

Labeled huprine derivatives and their use in medical imaging

Cedric Bouteiller , Franco Mariani Maurizio , Cyril Ronco , Pierre-Yves Renard , Ludovic Jean , et al.
France, Patent n° : WO 2011124713 A1. 2011
Patents hal-01150300v1

Novel uncharged reactivators against OP-inhibition of human acetylcholinesterase

Rachid Baati , Maria Klyachina , Valentin Nussbaum , Pierre-Yves Renard , Ludovic Jean , et al.
France, Patent n° : EP13306584.7. 2013
Patents hal-01150304v1

Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals

Tristan Verdelet , Guillaume Mercey , Nobi Correa , Ludovic Jean , Pierre-Yves Renard
Tetrahedron, 2011, 67 (45), pp.8757-8762. ⟨10.1016/j.tet.2011.09.024⟩
Journal articles istex hal-01017528v1

Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection

T.N. Pashirova , Anissa Braïki , I.V. Zueva , K.A. Petrov , V.M. Babaev , et al.
Journal of Controlled Release, 2018, 290, pp.102-111. ⟨10.1016/j.jconrel.2018.10.010⟩
Journal articles hal-02024524v1

Toward an innovative treatment of Alzheimer's disease: Synthesis and evaluation of multi-target directed ligands (MTDLs) targeting acetylcholinesterase (AChE) and alpha7 nicotinic acetylchloline receptors (alpha7 nAChRs)

Monika Cieslikiewicz-Bouet , Sovy Chao , Ludovic Jean , R. Araoz , D. Servent , et al.
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.209-210
Conference papers hal-02024978v1

Synthesis of new uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents

Anissa Braïki , Julien Renou , Catherine Gomez , Romain Mougeot , Florian Nachon , et al.
Tetrahedron Symposium (17, 2016), Jun 2016, Barcelone, Spain
Poster communications hal-02544884v1

Uncharged Reactivators of cholinesterases Inhibited by organophosphorus nerve agents

Pierre Warnault , Julien Renou , Catherine Gomez , Guillaume Mercey , Tristan Verdelet , et al.
International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain
Poster communications hal-02544902v1

Evaluation of three novel hydroxypicolinaldehyde oximes as efficient uncharged reactivators of VX-inhibited human acetylcholinesterase

Z. Kovarik , M. Katalinic , Ludovic Jean , Pierre-Yves Renard , Renou J. , et al.
FEBS-EMBO Anniversary Conference, Federation of European Biochemical Societies, Aug 2014, Paris, France. pp.65, ⟨10.1111/febs.12919⟩
Conference papers hal-02395537v1
Image document

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Paul Hermant , Damien Bosc , Catherine Piveteau , Ronan Gealageas , Baovy Lam , et al.
Journal of Medicinal Chemistry, 2017, 60 (21), pp.9067-9089. ⟨10.1021/acs.jmedchem.7b01444⟩
Journal articles hal-03054238v1

Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration

Tamara Zorbaz , Anissa Braïki , Nikola Marakovic , Julien Renou , Eugenio de La Mora , et al.
Chemistry - A European Journal, 2018, 24 (38), pp.9675-9691. ⟨10.1002/chem.201801394⟩
Journal articles hal-02024542v1

Réactivateurs d'acetylcholinestérase

Ludovic Jean
Journées scientifiques nucléaire radiologique biologique chimique et explosifs (NRBCE), Commissariat à l'Energie Atomique (CEA), Jan 2015, Saclay, France
Conference papers hal-02378480v1

Synthesis and luminescence properties of new red-shifted absorption lanthanide(III) chelates suitable for peptide and protein labelling.

Nicolas Maindron , Séverine Poupart , Maxime Hamon , Jean-Baptiste Langlois , Nelly Plé , et al.
Organic & Biomolecular Chemistry, 2011, 9 (7), pp.2357-2370. ⟨10.1039/c0ob00832j⟩
Journal articles hal-00991910v1

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents

Guillaume Mercey , Tristan Verdelet , Julien Renou , Maria Kliachyna , Rachid Baati , et al.
Accounts of Chemical Research, 2012, 45 (5), pp.756-766. ⟨10.1021/ar2002864⟩
Journal articles hal-01015972v1

Phosphine-catalyzed enantioselective [3+2] annulations of 2,3-butadienoates with imines

Ludovic Jean , A. Marinetti
Tetrahedron Letters, 2006, 47(13), pp.2141-2145. ⟨10.1016/j.tetlet.2006.01.122⟩
Journal articles istex hal-00097813v1

Palladium-Catalyzed Preparation of N-Alkylated Tacrine and Huprine Compounds

Cyril Ronco , Ludovic Jean , Hakim Outaabout , Pierre-Yves Renard
European Journal of Organic Chemistry, 2011, 2011 (2), pp.302-310. ⟨10.1002/ejoc.201001158⟩
Journal articles istex hal-01017284v1

Synthesis of difluoromethylphosphonamidates by direct addition of amine

Lucie Aliouane , Baptiste Rigaud , Emmanuel Pfund , Ludovic Jean , Pierre-Yves Renard , et al.
Tetrahedron Letters, 2011, 52 (28), pp.3681-3685. ⟨10.1016/j.tetlet.2011.05.034⟩
Journal articles istex hal-01017309v1

Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles

Pierrick Bruyat , Arnaud Gautier , Ludovic Jean , Pierre-Yves Renard
Journal of Organic Chemistry, 2018, 83 (21), pp.13515-13522. ⟨10.1021/acs.joc.8b01490⟩
Journal articles hal-01916360v1

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.

Julien Renou , Guillaume Mercey , Tristan Verdelet , Emilia Păunescu , Emilie Gillon , et al.
Chemico-Biological Interactions, 2013, 203 (1), pp.81-84. ⟨10.1016/j.cbi.2012.09.023⟩
Journal articles hal-00996535v1

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

Guillaume Mercey , Tristan Verdelet , Géraldine Saint-André , Emilie Gillon , Alain Wagner , et al.
Chemical Communications, 2011, 47 (18), pp.5295-5297. ⟨10.1039/c1cc10787a⟩
Journal articles hal-00991912v1