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The Sec61 translocon is a therapeutic vulnerability in multiple myeloma

Antoine Domenger , Caroline Choisy , Ludivine Baron , Véronique Mayau , Emeline Perthame et al.
EMBO Molecular Medicine, 2022, Online ahead of print., pp.e14740. ⟨10.15252/emmm.202114740⟩
Journal articles pasteur-03534527v1
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Synthetic lethality between PAXX and XLF in mammalian development.

Gabriel Balmus , Ana C. Barros , Paul W.G. Wijnhoven , Chloé Lescale , Hélène P Lenden Hasse et al.
Genes and Development, 2016, 30 (19), pp.2152 - 2157. ⟨10.1101/gad.290510.116⟩
Journal articles pasteur-01416628v1

The RAG2 C terminus suppresses genomic instability and lymphomagenesis.

Ludovic Deriano , Julie Chaumeil , Marc Coussens , Asha Multani , Yifan Chou et al.
Nature, 2011, 471 (7336), pp.119-23. ⟨10.1038/nature09755⟩
Journal articles pasteur-01471708v1
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RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.

Marc A Coussens , Rebecca L Wendland , Ludovic Deriano , Cory R Lindsay , Suzzette M Arnal et al.
Cell Reports, 2013, 4 (5), pp.870-8. ⟨10.1016/j.celrep.2013.07.041⟩
Journal articles pasteur-01471703v1
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RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

Chloé Lescale , Vincent Abramowski , Marie Bedora-Faure , Valentine Murigneux , Gabriella Vera et al.
Nature Communications, 2016, 7, pp.Article number:10529. ⟨10.1038/ncomms10529⟩
Journal articles pasteur-01295756v1

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

Harveer Dev , Ting-Wei Will Chiang , Chloé Lescale , Inge de Krijger , Alistair Martin et al.
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Journal articles pasteur-02757608v1
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Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination

Hélène Lenden Hasse , Chloé Lescale , Joy J. Bianchi , Wei Yu , Marie Bedora-Faure et al.
Journal of Immunological Methods, 2017, 451, pp.71-77. ⟨10.1016/j.jim.2017.08.007⟩
Journal articles pasteur-03271165v1
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Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells

Loelia Babin , Marion Piganeau , Benjamin Renouf , Khadija Lamribet , Cécile Thirant et al.
iScience, 2018, 5, pp.19-29. ⟨10.1016/j.isci.2018.06.007⟩
Journal articles mnhn-02402034v1
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Listeria monocytogenes Dampens the DNA Damage Response

Ascel Samba-Louaka , Jorge Pereira , Marie-Anne Nahori , Veronique Villiers , Ludovic Deriano et al.
PLoS Pathogens, 2014, 10 (10), pp.e1004470. ⟨10.1371/journal.ppat.1004470⟩
Journal articles pasteur-01078553v1
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The RAG recombinase: Beyond breaking.

Chloé Lescale , Ludovic Deriano
Mechanisms of Ageing and Development, 2016, ⟨10.1016/j.mad.2016.11.003⟩
Journal articles pasteur-01416603v1
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The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.

Julie Chaumeil , Mariann Micsinai , Panagiotis Ntziachristos , David B Roth , Iannis Aifantis et al.
Nature Communications, 2013, 4, pp.2231. ⟨10.1038/ncomms3231⟩
Journal articles pasteur-01471697v1
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Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers.

Julie Chaumeil , Mariann Micsinai , Panagiotis Ntziachristos , Ludovic Deriano , Joy M-H Wang et al.
Cell Reports, 2013, 3 (2), pp.359-70. ⟨10.1016/j.celrep.2013.01.024⟩
Journal articles pasteur-01471693v1
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Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage.

Ludovic Deriano , David B Roth
Annual Review of Genetics, 2013, 47 (1), pp.433-55. ⟨10.1146/annurev-genet-110711-155540⟩
Journal articles pasteur-01471700v1
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Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ

Wei Yu , Chloé Lescale , Loelia Babin , Marie Bedora-Faure , Hélène Lenden-Hasse et al.
Nature Communications, 2020, 11 (1), pp.5239. ⟨10.1038/s41467-020-19060-w⟩
Journal articles pasteur-03262335v1
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Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas

Joy Bianchi , Valentine Murigneux , Marie Bedora-Faure , Chloé Lescale , Ludovic Deriano et al.
Cell Reports, 2019, 27 (10), pp.2847-2858.e4. ⟨10.1016/j.celrep.2019.05.014⟩
Journal articles pasteur-02757480v1
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A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing.

Martina Mijušković , Stuart M Brown , Zuojian Tan , Cory R Lindsay , Efstratios Efstathiadis et al.
PLoS ONE, 2012, 7 (10), pp.e48314. ⟨10.1371/journal.pone.0048314⟩
Journal articles pasteur-01471706v1

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

Darragh Duffy , Vincent Rouilly , Valentina Libri , Milena Hasan , Benoit Beitz et al.
Immunity, 2014, 40 (3), pp.436-50. ⟨10.1016/j.immuni.2014.03.002⟩
Journal articles pasteur-01384537v1
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Paralogie et redondance : maintenir l’intégrité du génome au cours de la recombinaison V(D)J

Chloé Lescale , Hélène Lenden Hasse , Ludovic Deriano
médecine/sciences, 2017, 33 (5), pp.474-477. ⟨10.1051/medsci/20173305005⟩
Journal articles pasteur-03271173v1
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Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Chloé Lescale , Hélène Lenden Hasse , Andrew N Blackford , Gabriel Balmus , Joy J Bianchi et al.
Journal articles pasteur-01369781v1

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function

Miguel Galindo-Campos , Marie Bedora-Faure , Jordi Farrés , Chloé Lescale , Lucia Moreno-Lama et al.
Cell Death and Differentiation, 2019, 26 (12), pp.2667-2681. ⟨10.1038/s41418-019-0326-5⟩
Journal articles hal-02369061v1
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RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'.

Vered Gigi , Susanna Lewis , Olga Shestova , Martina Mijušković , Ludovic Deriano et al.
Nucleic Acids Research, 2014, 42 (10), pp.6352-64. ⟨10.1093/nar/gku295⟩
Journal articles pasteur-01471690v1

Fam72a enforces error-prone DNA repair during antibody diversification

Mélanie Rogier , Jacques Moritz , Isabelle Robert , Chloé Lescale , Vincent Heyer et al.
Nature, 2021, 600 (7888), pp.329-333. ⟨10.1038/s41586-021-04093-y⟩
Journal articles hal-03451745v1

The immune system profoundly restricts intratumor genetic heterogeneity

Idan Milo , Marie Bedora-Faure , Zacarias Garcia , Ronan Thibaut , Leïla Perié et al.
Science Immunology, 2018, 3 (29), pp.eaat1435. ⟨10.1126/sciimmunol.aat1435⟩
Journal articles pasteur-01939341v1