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Generation of analogues of stambomycins by genetic engineering and allied approaches

Li Su , Laurence Hôtel , Cédric Paris , Christophe Jacob , Bertrand Aigle et al.
15. Congrès National de la SFM (Société Française de Microbiologie), Oct 2019, Paris, France
Conference papers hal-03666910v1

Deciphering the structures of trans-AT polyketide synthase megaenzymes

Kira J. Weissman
2016
Other publications hal-03526010v1

Polyketides: applications in therapy and agriculture, development of new analogues using synthetic biology

Kira J. Weissman
2018
Other publications hal-03525977v1
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Editorial overview: Macromolecular assemblies: Assembly, dynamics and control of activity

Timm Maier , Kira J. Weissman
Current Opinion in Structural Biology, 2018, 49, pp.vi-vii. ⟨10.1016/j.sbi.2018.04.001⟩
Journal articles hal-02956617v1

Engineering of a polyketide synthase leads to 'low-fat' stambomycins

Li Su , Laurence Hôtel , Cédric Paris , Christophe Jacob , Bertrand Aigle et al.
Journées francophones d'actinobactéries (ACTINO 2020), Dec 2020, On-line, France
Conference papers hal-03525244v1

Successes, surprises and pitfalls in modular polyketide synthase engineering

Kira J. Weissman , Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui et al.
2nd International Conference on Biomolecules and the Bioeconomy, Nov 2021, Nancy, France
Conference papers hal-03525292v1

The structural biology of modular polyketide synthases: insights and implications for synthetic biology

Kira J. Weissman , Jonathan Dorival , Thibault Annaval , Fanny Risser , Sabrina Collin et al.
European Workshop on Natural Product Biosynthesis, Jun 2017, Gif-sur-Yvete, France
Conference papers hal-01736000v1

The structural biology of modular polyketide synthases: insights and implications for synthetic biology

Kira J. Weissman
2017
Other publications hal-03525991v1

Deciphering the structures of trans-AT polyketide synthase megaenzymes

Kira J. Weissman
2016
Other publications hal-03526020v1

Uncovering the structures of modular polyketide synthases

Kira J. Weissman
Natural Product Reports, 2015, 32 (3), pp.436 - 453. ⟨10.1039/c4np00098f⟩
Journal articles hal-01474063v1

Unpackaging the Roles of Streptomyces Natural Products

Christophe Jacob , Kira J. Weissman
Cell Chemical Biology, 2017, 24 (10), pp.1194 - 1195. ⟨10.1016/j.chembiol.2017.09.013⟩
Journal articles hal-01671016v1

Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry

Thibault Annaval , Cedric Paris , Peter F. Leadlay , Christophe Jacob , Kira J. Weissman et al.
ChemBioChem, 2015, 16 (9), pp.1357-1364. ⟨10.1002/cbic.201500113⟩
Journal articles istex hal-01278114v1
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Towards improved understanding of intersubunit interactions in modular polyketide biosynthesis: Docking in the enacyloxin IIa polyketide synthase

Fanny Risser , Sabrina Collin , Raphael dos Santos-Morais , Arnaud Gruez , Benjamin Chagot et al.
Journal of Structural Biology, 2020, 212 (1), pp.107581. ⟨10.1016/j.jsb.2020.107581⟩
Journal articles hal-02926190v1

Bacterial Type I Polyketide Synthases

Kira J. Weissman
Comprehensive Natural Products III - Third edition, 1, Elsevier, pp.4-46, 2020, 978-0-08-102691-5. ⟨10.1016/B978-0-12-409547-2.14644-X⟩
Book sections hal-02956621v1

Structure-function relationships in modular PKSs and their application to genetic engineering

Kira J. Weissman
2020
Other publications hal-03525856v1
Image document

Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

Jean-Malo Massicard , Claire Soligot , Kira J. Weissman , Christophe Jacob
Chemical Communications, 2020, 56, pp.12749-12752. ⟨10.1039/D0CC05068G⟩
Journal articles hal-02937132v1

Creating analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches

Li Su , Hotel L , Christophe Jacob , Kira J Weissman , Bertrand Aigle et al.
2018, 2018, Nancy, France
Poster communications hal-03016980v1

Probing interactions in fungal PKS

Kira J Weissman
Chemistry & biology, 2013, 20 (9), pp.1089-91. ⟨10.1016/j.chembio1.2013.09.001⟩
Journal articles hal-01467279v1

The structural biology of modular polyketide synthases: insights and implications for synthetic biology

Kira J Weissman , Jack Davison , Jonathan Dorival , Thibault Annaval , Fanny Risser et al.
3rd European Conference on Natural Products, 2018, Frankfurt, Germany
Conference papers hal-02956684v1

Function of polyketide synthases from the SAXS structure of a complete module

Jack Davison , Jonathan Dorival , Hery Rabeharindranto , Hortense Mazon , Benjamin Chagot et al.
Acta Crystallographica Section A : Foundations and Advances [2014-..], 2014, 70 (a1), pp.C407 - C407. ⟨10.1107/S2053273314095928⟩
Journal articles hal-01653555v1

Polyketide stereocontrol: a study in chemical biology

Kira J. Weissman
Beilstein Journal of Organic Chemistry, 2017, 13, pp.348 - 371. ⟨10.3762/bjoc.13.39⟩
Journal articles hal-01671019v1

Genome mining: accessing Nature’s natural product diversity

Kira J Weissman
Biomolecules: Research & Development, Markets and Acceptability, 2019, Palma de Majorca, Spain
Conference papers hal-03016889v1

The structural biology of biosynthetic megaenzymes

Kira J Weissman
Nature Chemical Biology, 2015, 11 (9), pp.660 - 670. ⟨10.1038/NCHEMBIO.1883⟩
Journal articles hal-01474060v1

Characterization of Intersubunit Communication in the Virginiamycin trans-AT Polyketide Synthase

Jonathan Dorival , Thibault Annaval , Fanny Risser , Sabrina Collin , Pierre Roblin et al.
Directing Biosynthesis V, Mar 2017, Warwick, United Kingdom
Poster communications hal-01735993v1

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

Li Su , Laurence Hôtel , Cédric Paris , Clara Chepkirui , Alexander Brachmann et al.
Nature Communications, 2022, 13 (1), pp.515. ⟨10.1038/s41467-022-27955-z⟩
Journal articles hal-03544763v1

Structure-function relationships in modular PKSs and their application to genetic engineering

Kira J. Weissman
2020
Other publications hal-03525836v1
Image document

Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology

Kira J. Weissman
Natural Product Reports, 2016, 33 (2), pp.203 - 230. ⟨10.1039/c5np00109a⟩
Journal articles hal-01474079v1
Image document

Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis

Jonathan Dorival , Fanny Risser , Christophe Jacob , Sabrina Collin , Gerald Dräger et al.
Nature Communications, 2018, 9 (1), pp.3998. ⟨10.1038/s41467-018-06323-w⟩
Journal articles hal-01980537v1
Image document

Towards the sustainable discovery and development of new antibiotics

Marcus Miethke , Marco Pieroni , Tilmann Weber , Mark Brönstrup , Peter Hammann et al.
Nature Reviews Chemistry, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩
Journal articles pasteur-03427787v1

Deciphering the structures of trans-AT polyketide synthases

Kira J. Weissman , Jack Davison , Jonathan Dorival , Thibault Annaval , Fanny Risser et al.
BMWZ Symposium, Sep 2016, Hannover, Germany
Conference papers hal-01735998v1