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Synthesis and Antiviral Evaluation of Cyclic and Acyclic 2-Methyl-3-hydroxy-4-pyridinone Nucleoside Derivatives

Karine Barral , Jan Balzarini , Johan Neyts , Erik de Clercq , Robert Hider , et al.
Journal of Medicinal Chemistry, 2006, 49 (1), pp.43-50. ⟨10.1021/jm0504306⟩
Journal articles istex hal-02061660v1

Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase

Fatiha Benmansour , Cecilia Eydoux , Gilles Querat , Xavier de Lamballerie , Bruno Canard , et al.
European Journal of Medicinal Chemistry, 2016, 109, pp.146-156. ⟨10.1016/j.ejmech.2015.12.046⟩
Journal articles hal-02061730v1

Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

Karine Barral , Clément Weck , Nadine Payrot , Loic Roux , Céline Durafour , et al.
European Journal of Medicinal Chemistry, 2011, 46 (9), pp.4281-4288. ⟨10.1016/j.ejmech.2011.06.034⟩
Journal articles hal-02061721v1

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Karine Barral , Corinne Sallamand , Christiane Petzold , Bruno Coutard , Axelle Collet , et al.
Antiviral Research, 2013, 99 (3), pp.292-300. ⟨10.1016/j.antiviral.2013.06.001⟩
Journal articles hal-00874640v1

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

Bruno Coutard , Etienne Decroly , Changqing Li , Andrew Sharff , Julien Lescar , et al.
Antiviral Research, 2014, 106, pp.61-70. ⟨10.1016/j.antiviral.2014.03.013⟩
Journal articles hal-02061701v1
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Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

Bruno Coutard , Karine Barral , Julie Lichiere , Barbara Selisko , Baptiste Martin , et al.
Journal of Virology, 2017, 91 (5), pp.2202-2218. ⟨10.1128/JVI.02202-16⟩
Journal articles hal-01802793v1

Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

Fatiha Benmansour , Iuni Trist , Bruno Coutard , Etienne Decroly , Gilles Querat , et al.
European Journal of Medicinal Chemistry, 2017, 125, pp.865-880. ⟨10.1016/j.ejmech.2016.10.007⟩
Journal articles hal-02061703v1

Preparation of thiophenepropenamide derivatives as flavivirus inhibitors in treatment of viral infections

Karine Barral , Jean Claude Guillemot , Bruno Canard , Gilles Quérat , Karine Alvarez , et al.
France, Patent n° : WO 2017102014. 2017
Patents hal-02063286v1
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Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

R. Leblanc , R. Kashyap , K. Barral , A.L. Egea‐jimenez , D. Kovalskyy , et al.
Journal of Extracellular Vesicles, 2020, 10 (2), ⟨10.1002/jev2.12039⟩
Journal articles hal-03152593v1

Preparation of purine and pyrimidine acyclic nucleotide analogs as antiviral agents

Karine Barral , Bruno Canard , Karine Alvarez , Jean-Louis Romette , Johan Neyts , et al.
France, Patent n° : WO 2007-IB4233. 2007
Patents hal-02063281v1
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Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Jessica Hernandez , Laurent Hoffer , Bruno Coutard , Gilles Quérat , Philippe Roche , et al.
European Journal of Medicinal Chemistry, 2019, 161 (4), pp.323-333. ⟨10.1016/j.ejmech.2018.09.056⟩
Journal articles inserm-02378768v1

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

D. Topalis , K. Alvarez , K. Barral , Hélène Munier-Lehmann , B. Schneider , et al.
Nucleosides, Nucleotides and Nucleic Acids, 2008, 27 (4), pp.319-31. ⟨10.1080/15257770801941952⟩
Journal articles pasteur-00316017v1
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In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

Franck Touret , Magali Gilles , Karine Barral , Antoine Nougairède , Jacques van Helden , et al.
Scientific Reports, 2020, 10 (1), pp.13093. ⟨10.1038/s41598-020-70143-6⟩
Journal articles inserm-02944556v1

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

Karine Barral , Robert Hider , Jan Balzarini , Johan Neyts , Erik de Clercq , et al.
Bioorganic and Medicinal Chemistry Letters, 2003, 13 (24), pp.4371-4374. ⟨10.1016/j.bmcl.2003.09.033⟩
Journal articles istex hal-02061650v1

Synthesis and Antiviral Evaluation of Cis-Substituted Cyclohexenyl and Cyclohexanyl Nucleosides

Karine Barral , Jérôme Courcambeck , Gérard Pèpe , Jan Balzarini , Johan Neyts , et al.
Journal of Medicinal Chemistry, 2005, 48 (2), pp.450-456. ⟨10.1021/jm0493966⟩
Journal articles istex hal-02061654v1

Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

Antoine Frangeul , Cécile Bussetta , Jérôme Deval , Karine Barral , Karine Alvarez , et al.
Antiviral Therapy, 2019, 13 (1), pp.115-24
Journal articles hal-02061712v1

Synthesis of (±) cis-substituted cyclohexenyl and cyclohexanyl nucleosides via a double Mitsunobu-type reaction

Karine Barral , Philippe Halfon , Gérard Pèpe , Michel Camplo
Tetrahedron Letters, 2002, 43 (1), pp.81-84. ⟨10.1016/S0040-4039(01)02107-4⟩
Journal articles istex hal-02061647v1

Efficient Conversion of Aromatic Amines into Azides: A One-Pot Synthesis of Triazole Linkages

Karine Barral , Adam Moorhouse , John Moses
Organic Letters, 2007, 9 (9), pp.1809-1811. ⟨10.1021/ol070527h⟩
Journal articles hal-02061672v1

In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5'-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives

A. Frangeul , Karine Barral , K. Alvarez , B. Canard
Antimicrobial Agents and Chemotherapy, 2007, 51 (9), pp.3162-3167. ⟨10.1128/AAC.00145-07⟩
Journal articles hal-02061675v1

Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

Karine Alvarez , Jérôme Deval , Boulbaba Selmi , Karine Barral , Joelle Boretto , et al.
Nucleosides, Nucleotides and Nucleic Acids, 2005, 24 (5-7), pp.419-422. ⟨10.1081/NCN-200059951⟩
Journal articles hal-02061659v1

Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and ( R )-9-[2-(Phosphonomethoxy)propyl]adenine

Karine Barral , Stephane Priet , Joséphine Sire , Johan Neyts , Jan Balzarini , et al.
Journal of Medicinal Chemistry, 2006, 49 (26), pp.7799-7806. ⟨10.1021/jm060030y⟩
Journal articles istex hal-02061667v1

Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates

Karine Barral , Stephane Priet , Céline de Michelis , Joséphine Sire , Johan Neyts , et al.
European Journal of Medicinal Chemistry, 2010, 45 (2), pp.849-856. ⟨10.1016/j.ejmech.2009.11.012⟩
Journal articles istex hal-02061692v1
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Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach

Laurent Hoffer , Manon Garcia , Raphael Leblanc , Mikael Feracci , Stéphane Betzi , et al.
Journal of Medicinal Chemistry, 2023, ⟨10.1021/acs.jmedchem.2c01569⟩
Journal articles hal-04048842v1