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Synthesis and Antiviral Evaluation of Cyclic and Acyclic 2-Methyl-3-hydroxy-4-pyridinone Nucleoside Derivatives
Karine Barral
,
Jan Balzarini
,
Johan Neyts
,
Erik de Clercq
,
Robert Hider
,
et al.
Journal articles
istex
hal-02061660v1
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Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase
Fatiha Benmansour
,
Cecilia Eydoux
,
Gilles Querat
,
Xavier de Lamballerie
,
Bruno Canard
,
et al.
Journal articles
hal-02061730v1
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Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication
Karine Barral
,
Clément Weck
,
Nadine Payrot
,
Loic Roux
,
Céline Durafour
,
et al.
Journal articles
hal-02061721v1
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Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.
Karine Barral
,
Corinne Sallamand
,
Christiane Petzold
,
Bruno Coutard
,
Axelle Collet
,
et al.
Journal articles
hal-00874640v1
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Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery
Bruno Coutard
,
Etienne Decroly
,
Changqing Li
,
Andrew Sharff
,
Julien Lescar
,
et al.
Journal articles
hal-02061701v1
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Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives
Bruno Coutard
,
Karine Barral
,
Julie Lichiere
,
Barbara Selisko
,
Baptiste Martin
,
et al.
Journal articles
hal-01802793v1
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Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design
Fatiha Benmansour
,
Iuni Trist
,
Bruno Coutard
,
Etienne Decroly
,
Gilles Querat
,
et al.
Journal articles
hal-02061703v1
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Preparation of thiophenepropenamide derivatives as flavivirus inhibitors in treatment of viral infections
Karine Barral
,
Jean Claude Guillemot
,
Bruno Canard
,
Gilles Quérat
,
Karine Alvarez
,
et al.
France, Patent n° : WO 2017102014. 2017
Patents
hal-02063286v1
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Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo
R. Leblanc
,
R. Kashyap
,
K. Barral
,
A.L. Egea‐jimenez
,
D. Kovalskyy
,
et al.
Journal articles
hal-03152593v1
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Preparation of purine and pyrimidine acyclic nucleotide analogs as antiviral agents
Karine Barral
,
Bruno Canard
,
Karine Alvarez
,
Jean-Louis Romette
,
Johan Neyts
,
et al.
France, Patent n° : WO 2007-IB4233. 2007
Patents
hal-02063281v1
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Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors
Jessica Hernandez
,
Laurent Hoffer
,
Bruno Coutard
,
Gilles Quérat
,
Philippe Roche
,
et al.
Journal articles
inserm-02378768v1
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Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.
D. Topalis
,
K. Alvarez
,
K. Barral
,
Hélène Munier-Lehmann
,
B. Schneider
,
et al.
Journal articles
pasteur-00316017v1
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In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication
Franck Touret
,
Magali Gilles
,
Karine Barral
,
Antoine Nougairède
,
Jacques van Helden
,
et al.
Journal articles
inserm-02944556v1
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Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives
Karine Barral
,
Robert Hider
,
Jan Balzarini
,
Johan Neyts
,
Erik de Clercq
,
et al.
Journal articles
istex
hal-02061650v1
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Synthesis and Antiviral Evaluation of Cis-Substituted Cyclohexenyl and Cyclohexanyl Nucleosides
Karine Barral
,
Jérôme Courcambeck
,
Gérard Pèpe
,
Jan Balzarini
,
Johan Neyts
,
et al.
Journal articles
istex
hal-02061654v1
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Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.
Antoine Frangeul
,
Cécile Bussetta
,
Jérôme Deval
,
Karine Barral
,
Karine Alvarez
,
et al.
Antiviral Therapy, 2019, 13 (1), pp.115-24
Journal articles
hal-02061712v1
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Synthesis of (±) cis-substituted cyclohexenyl and cyclohexanyl nucleosides via a double Mitsunobu-type reaction
Karine Barral
,
Philippe Halfon
,
Gérard Pèpe
,
Michel Camplo
Journal articles
istex
hal-02061647v1
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Efficient Conversion of Aromatic Amines into Azides: A One-Pot Synthesis of Triazole Linkages
Karine Barral
,
Adam Moorhouse
,
John Moses
Journal articles
hal-02061672v1
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In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5'-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives
A. Frangeul
,
Karine Barral
,
K. Alvarez
,
B. Canard
Journal articles
hal-02061675v1
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Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance
Karine Alvarez
,
Jérôme Deval
,
Boulbaba Selmi
,
Karine Barral
,
Joelle Boretto
,
et al.
Journal articles
hal-02061659v1
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Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and ( R )-9-[2-(Phosphonomethoxy)propyl]adenine
Karine Barral
,
Stephane Priet
,
Joséphine Sire
,
Johan Neyts
,
Jan Balzarini
,
et al.
Journal articles
istex
hal-02061667v1
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Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates
Karine Barral
,
Stephane Priet
,
Céline de Michelis
,
Joséphine Sire
,
Johan Neyts
,
et al.
Journal articles
istex
hal-02061692v1
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Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach
Laurent Hoffer
,
Manon Garcia
,
Raphael Leblanc
,
Mikael Feracci
,
Stéphane Betzi
,
et al.
Journal articles
hal-04048842v1
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