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Giardia duodenalis induces paracellular bacterial translocation and causes postinfectious visceral hypersensitivity

Marie C M Halliez , Jean-Paul Motta , Troy D Feener , Gaëtan Guerin , Laetitia Legoff et al.
AJP - Gastrointestinal and Liver Physiology, 2016, 310, pp.574 - 585. ⟨10.1152/ajpgi.00144.2015⟩
Journal articles hal-02317886v1
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Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

Jean-Paul Motta , Corinne Rolland , Anissa Edir , Ana-Carolina Florence , David Sagnat et al.
Mucosal Immunology, 2021, 14 (3), pp.667-678. ⟨10.1038/s41385-021-00375-w⟩
Journal articles hal-03172288v1
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Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis

Jean-Paul Motta* , Laurent Magne* , Delphyne Descamps , Corinne Rolland , Camila Squarzoni-Dale et al.
Gastroenterology, 2010, 140 (4), pp.1272-82. ⟨10.1053/j.gastro.2010.12.050⟩
Journal articles pasteur-00552947v1
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High-fat diet increases the severity of Giardia infection in association with low-grade inflammation and gut microbiota dysbiosis

Thibault Allain , Elena Fekete , Olivia Sosnowski , Dimitri Desmonts de Lamache , Jean-Paul Motta et al.
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-98262-8⟩
Journal articles hal-03376671v1
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Epithelial expression and function of trypsin-3 in irritable bowel syndrome

Claire Rolland , Alexandre Denadai-Souza , Carla Cirillo , Cintya Lopez , Josue Obed Jaramillo et al.
Gut, 2017, 66 (10), pp.1767-1778. ⟨10.1136/gutjnl-2016-312094⟩
Journal articles hal-01604269v1
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Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

John L. Wallace , Jean-Paul Motta , Andre G. Buret
AJP - Gastrointestinal and Liver Physiology, 2018, 314 (2), pp.G143 - G149. ⟨10.1152/ajpgi.00249.2017⟩
Journal articles hal-02623161v1

PAR-1 Antagonism to Promote Gut Mucosa Healing in Crohn’s Disease Patients: A New Avenue for CVT120165

Jean-Paul Motta , Celine Deraison , Sylvie Le Grand , Bruno Le Grand , Nathalie Vergnolle et al.
Inflammatory Bowel Diseases, 2021, 27 (Supplement_2), pp.S33-S37. ⟨10.1093/ibd/izab244⟩
Journal articles hal-03590828v1
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Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation

Jean-Paul Motta , Simone Palese , Carmine Giorgio , Kevin Chapman , Alexandre Denadai-Souza et al.
Journal of Crohn's and Colitis, 2021, 15 (5), pp.787-799. ⟨10.1093/ecco-jcc/jjaa229⟩
Journal articles hal-03073920v2
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Active thrombin produced by the intestinal epithelium controls mucosal biofilms

Jean-Paul Motta , Alexandre Denadai-Souza , David Sagnat , Laura Guiraud , Anissa Edir et al.
Nature Communications, 2019, 10 (1), pp.3224. ⟨10.1038/s41467-019-11140-w⟩
Journal articles inserm-02232741v1

Lactic acid bacteria recombinant for the expression of antiprotease inhibit visceral pain and hypersensitivity

M. Castro , Laurence Martin , Nicolas Cenac , Jean-Paul Motta , M. A. Plaza et al.
16. Neurogastroenterology and Motility Meeting, Sep 2011, Saint-Louis, United States. Wiley-Blackwell, Neurogastroenterology and Motility, 23 (SI), 55 p., 2011, Neurogastroenterology and Motility. ⟨10.1111/j.1365-2982.2011.01757.x⟩
Poster communications hal-01204294v1

Giardia duodenalis alters intestinal mucin transcription and disrupts the mucus layer in a cysteine protease-dependent manner

Christina B. Amat , Jean-Paul Motta , Kris Chadee , Andre G. Buret
FASEB Journal, 2017, 31 (1)
Journal articles hal-02617790v1

Co-infection with Giardia duodenalis protects the host against enteropathogenic Escherichia coli via NLRP3 inflammasome-dependent anti-microbial peptide production

Anna Manko , Jean-Paul Motta , James Cotton , Ayodele Oyeyemi , Bruce Vallance et al.
FASEB Journal, 2017, 31 (1)
Journal articles hal-02617901v1

Western Diet Increases the Severity of Giardia Infection in Association with Gut Microbiota Dysbiosis

Thibault Allain , Dimitri Desmonts de Lamache , Olivia Sosnowski , Elena Fekete , Jean-Paul Motta et al.
Annual Meeting on Experimental Biology, Amer Assoc Anatomists; Amer Physiol Soc; Amer Soc Biochem & Mol Biol; Amer Soc Investigat Pathol; Amer Soc Nutr; Amer Soc Pharmacol & Expt Therapeut, Apr 2020, San Diego, France. pp.1, ⟨10.1096/fasebj.2020.34.s1.07347⟩
Conference papers hal-02986639v1
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Uropathogenic E. coli induces DNA damage in the bladder

Camille Chagneau , Clémence Massip , Nadège Bossuet-Greif , Christophe Fremez , Jean-Paul Motta et al.
PLoS Pathogens, 2021, 17 (2), 18 p. ⟨10.1371/journal.ppat.1009310⟩
Journal articles hal-03173303v1

Novel role of the serine protease inhibitor elafin in gluten-related disorders

Heather J Galipeau , Michelle Wiepjes , Jean-Paul Motta , Jessica D Schulz , Jennifer Jury et al.
The American Journal of Gastroenterology, 2014, 109 (5), pp.748-56. ⟨10.1038/ajg.2014.48⟩
Journal articles hal-01204309v1

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

Jean-Paul Motta , Luis Bermudez Humaran , Céline Deraison , Laurence Martin , Corinne Rolland et al.
Science Translational Medicine, 2012, 4 (158), ⟨10.1126/scitranslmed.3004212⟩
Journal articles hal-01204261v1

Using murine colitis models to analyze probiotics–host interactions

Rebeca Martin Rosique , Florian Chain , Sylvie Miquel , Jean-Paul Motta , Nathalie Vergnolle et al.
FEMS Microbiology Reviews, 2017, 41 (Supp_1), pp.S49-S70. ⟨10.1093/femsre/fux035⟩
Journal articles hal-01602302v1
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Oral administration of recombinant lactic acid bacteria delivering antiproteases at the mucosal level protects mice from colitis

L.L. Martin , Jean-Paul Motta , Luis L. Bermudez Humaran , Pascale P. Kharrat , J. -M. J. -M. Sallenave et al.
10. World Congress on Inflammation, Jun 2011, Paris, France. pp.S80, ⟨10.1007/s00011-011-0341-6⟩
Conference papers hal-01001507v1
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Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci

Luis Bermudez Humaran , Jean-Paul Motta , Camille Aubry , Pascale Kharrat , Laurence Rous-Martin et al.
Microbial Cell Factories, 2015, 14, ⟨10.1186/s12934-015-0198-4⟩
Journal articles hal-01204481v1

Engineering lactococci and lactobacilli for human health

Luis Bermúdez-Humarán , Camille Aubry , Jean-Paul Motta , Céline Deraison , Lothar Steidler et al.
Current Opinion in Microbiology, 2013, 16 (3), pp.278-283. ⟨10.1016/j.mib.2013.06.002⟩
Journal articles hal-01003315v1
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A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917

Jean-Philippe Nougayrède , Camille Chagneau , Jean-Paul Motta , Nadège Bossuet-Greif , Marcy Belloy et al.
MSphere, 2021, 6 (4), 11 p. ⟨10.1128/mSphere.00624-21⟩
Journal articles hal-03358727v2
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Identification of bacterial lipopeptides as key players in IBS

Camille Petitfils , Sarah Maurel , Gaelle Payros , Amandine Hueber , Bahija Agaiz et al.
Gut, 2022, pp.328084. ⟨10.1136/gutjnl-2022-328084⟩
Journal articles hal-03833107v1