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Mechanism of Naphthoquinone Selectivity of Thymidylate Synthase ThyX

Hannu Myllykallio , Hubert F Becker , Alexey Aleksandrov
Biophysical Journal, 2020, 119 (12), pp.2508-2516. ⟨10.1016/j.bpj.2020.10.042⟩
Journal articles hal-03026531v1
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Mechanistic and structural basis for inhibition of thymidylate synthase ThyX

Tamara Basta , Yap Boum , Julien Briffotaux , Hubert F. Becker , Isabelle Lamarre-Jouenne et al.
Open Biology, 2012, 2 (-), ⟨10.1098/rsob.120120⟩
Journal articles hal-00817165v1
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Synthesis and structure–activity relationship studies of pyrido [1,2-e]purine-2,4(1H,3H)-dione derivatives targeting Flavin-Dependent $Thymidylate\ Synthase$ in $Mycobacterium\ tuberculosis$

Nicolas G. Biteau , Vincent Roy , Cyril Nicolas , Hubert F Becker , Jean-Christophe Lambry et al.
Molecules, 2022, 27, pp.6216. ⟨10.3390/molecules27196216⟩
Journal articles hal-03798565v1

Utilisation d'un polypeptide THYX ou d'un acide nucléique codant un tel polypeptide, notamment pour le criblage de composés anti-bactériens ou anti-viraux

Ursula Liebl , Gérard Lipowski , Jean-Louis Martin , Hannu Myllykallio
France, N° de brevet: FR20010010401. 2001
Patents hal-01079107v1

Antimicrobial compounds of 1,4- naphtoquinone structure

Hannu Myllykallio , Tamara Basta , Yap Boum , Ursula Liebl
France, Patent n° : WO2011EP55537. 2010
Patents hal-01080259v1
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Mechanistic and structural basis for inhibition of thymidylate synthase ThyX

Tamara Basta , Yap Boum , Julien Briffotaux , Hubert F Becker , Isabelle Lamarre-Jouenne et al.
Open Biology, 2012, 2 (10), pp.120120. ⟨10.1098/rsob.120120⟩
Journal articles hal-03298488v1

Advances and challenges in drug design against tuberculosis: application of in silico approaches

Alexey Aleksandrov , Hannu Myllykallio
Expert Opinion on Drug Discovery, 2018, pp.1 - 12. ⟨10.1080/17460441.2019.1550482⟩
Journal articles hal-01937463v1

Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori

Andreea Sodolescu , Cyril Dian , Laurent Terradot , Latifa Bouzhir-Sima , Roxane Lestini et al.
PLoS ONE, 2018, 13 (12), pp.e0208850. ⟨10.1371/journal.pone.0208850⟩
Journal articles hal-01958538v1
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Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression

Alessio Ligabue , G. Marverti , Ursula Liebl , Hannu Myllykallio
PLoS ONE, 2012, 7 (10), pp.e47318. ⟨10.1371/journal.pone.0047318⟩
Journal articles hal-00817154v1