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Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

Philippe Mangeot , Valérie Risson , Floriane Fusil , Aline Marnef , Emilie Laurent et al.
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-018-07845-z⟩
Journal articles hal-02351895v1

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

Pierre Caron , Francois Aymard , Jason Iacovoni , Sébastien Briois , Yvan Canitrot et al.
PLoS Genetics, 2012, 8 (1), pp.e1002460. ⟨10.1371/journal.pgen.1002460⟩
Journal articles hal-03481119v1
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Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation

Coline Arnould , Vincent Rocher , Thomas Clouaire , Pierre Caron , Philippe E Mangeot et al.
2020
Preprints, Working Papers, ... hal-02991048v1

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox

Alexandra Vítor , Pablo Huertas , Gaëlle Legube , Sérgio de Almeida
Frontiers in Molecular Biosciences, 2020, 7, ⟨10.3389/fmolb.2020.00024⟩
Journal articles hal-03011382v1

Loop extrusion as a mechanism for formation of DNA damage repair foci

Coline Arnould , Vincent Rocher , Anne-Laure Finoux , Thomas Clouaire , Kevin Li et al.
Nature, 2021, 590 (7847), pp.660-665. ⟨10.1038/s41586-021-03193-z⟩
Journal articles hal-03476964v1

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

Thomas Clouaire , Vincent Rocher , Anahita Lashgari , Coline Arnould , Marion Aguirrebengoa et al.
Molecular Cell, 2018, 72 (2), pp.250-262.e6. ⟨10.1016/j.molcel.2018.08.020⟩
Journal articles hal-02352384v1
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Analyzing Homologous Recombination at a Genome-Wide Level

Coline Arnould , Gaëlle Legube
Journal of Molecular Biology, 2021, 432 (3), pp.427-438. ⟨10.1007/978-1-0716-0644-5_29⟩
Journal articles hal-03011376v1
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Loop extrusion as a mechanism for formation of DNA damage repair foci

Coline Arnould , Vincent Rocher , Anne-Laure Finoux , Thomas Clouaire , Kevin Li et al.
Nature, 2021, 590 (7847), pp.660-665. ⟨10.1038/s41586-021-03193-z⟩
Journal articles hal-03385752v1

A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation

S. Cohen , A. Guenolé , I. Lazar , A. Marnef , T. Clouaire et al.
Nature Communications, 2022, 13 (1), pp.2012. ⟨10.1038/s41467-022-29629-2⟩
Journal articles hal-03842463v1

Quantifying DNA double-strand breaks induced by site-specific endonucleases in living cells by ligation-mediated purification

Catherine Chailleux , François Aymard , Pierre Caron , Virginie Daburon , Céline Courilleau et al.
Nature Protocols, 2014, 9 (3), pp.517-528. ⟨10.1038/nprot.2014.031⟩
Journal articles hal-03477016v1
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A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks

Thomas Clouaire , Gaëlle Legube
Trends in Genetics, 2019, 35 (5), pp.330-345. ⟨10.1016/j.tig.2019.02.003⟩
Journal articles hal-02352378v1
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ATM-dependent formation of a novel chromatin compartment regulates the Response to DNA Double Strand Breaks and the biogenesis of translocations

Coline Arnould , Vincent Rocher , Aldo S Bader , Emma Lesage , Nadine Puget et al.
2022
Preprints, Working Papers, ... hal-03818730v1

HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses

Edwige Col , Cécile Caron , Christine Chable-Bessia , Gaëlle Legube , Sylvie Gazzeri et al.
EMBO Journal, 2005, 24 (14), pp.2634-2645. ⟨10.1038/sj.emboj.7600734⟩
Journal articles hal-02345600v1

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

François Aymard , Beatrix Bugler , Christine Schmidt , Emmanuelle Guillou , Pierre Caron et al.
Nature Structural and Molecular Biology, 2014, 21 (4), pp.366-374. ⟨10.1038/nsmb.2796⟩
Journal articles hal-03477002v1
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Tip60 acetyltransferase activity is controlled by phosphorylation.

Claudie Lemercier , Gaëlle Legube , Cécile Caron , Mathilde Louwagie , Jérôme Garin et al.
Journal of Biological Chemistry, 2003, 278 (7), pp.4713-8. ⟨10.1074/jbc.M211811200⟩
Journal articles hal-00380484v1
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Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

Pierre Caron , Francois Aymard , Jason Iacovoni , Sébastien Briois , Yvan Canitrot et al.
PLoS Genetics, 2012, 8 (1), pp.e1002460. ⟨10.1371/journal.pgen.1002460⟩
Journal articles hal-03477020v1

Deciphering the chromatin landscape induced around DNA double strand breaks

Laurent Massip , Pierre Caron , Jason Iacovoni , Didier Trouche , Gaëlle Legube et al.
Cell Cycle, 2014, 9 (15), pp.3035-3044. ⟨10.4161/cc.9.15.12412⟩
Journal articles hal-03477023v1

m6A RNA modification as a new player in R-loop regulation

Aline Marnef , Gaëlle Legube
Nature Genetics, 2020, 52 (1), pp.27-28. ⟨10.1038/s41588-019-0563-z⟩
Journal articles hal-03011341v1

Des mécanismes moléculaires aux applications cliniques. L’essentiel du Colloque Réplication-Réparation-Recombinaison 2019

Sarah Lambert , Valérie Borde , Jean-Baptiste Charbonnier , Françoise Dantzer , Olivier Espéli et al.
Bulletin du Cancer, 2020, 107 (2), pp.283-287. ⟨10.1016/j.bulcan.2020.01.003⟩
Journal articles hal-03048287v1

Des mécanismes moléculaires aux applications cliniques. L’essentiel du Colloque Réplication-Réparation-Recombinaison 2019

Sarah Lambert , Valérie Borde , Jean-Baptiste Charbonnier , Françoise Dantzer , Olivier Espéli et al.
Bulletin du Cancer, 2020, 107 (2), pp.283-287. ⟨10.1016/j.bulcan.2020.01.003⟩
Journal articles hal-03040975v1
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Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

Pierre Caron , Jonathan Choudjaye , Thomas Clouaire , Béatrix Bugler , Virginie Daburon et al.
Cell Reports, 2015, 13 (8), pp.1598-1609. ⟨10.1016/j.celrep.2015.10.024⟩
Journal articles hal-03476981v1
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Quantitation of DNA double-strand break resection intermediates in human cells

Yi Zhou , Pierre Caron , Gaëlle Legube , Tanya Paull
Nucleic Acids Research, 2014, 42 (3), pp.e19-e19. ⟨10.1093/nar/gkt1309⟩
Journal articles hal-03477011v1

Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution

Raphaël Mourad , Krzysztof Ginalski , Gaëlle Legube , Olivier Cuvier
Genome Biology, 2018, 19 (1), ⟨10.1186/s13059-018-1411-7⟩
Journal articles hal-02352388v1

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells

Yizhou Joseph He , Khyati Meghani , Marie-Christine Caron , Chunyu Yang , Daryl Ronato et al.
Nature, 2018, 563 (7732), pp.522-526. ⟨10.1038/s41586-018-0670-5⟩
Journal articles hal-02352382v1
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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Sarah Cohen , Nadine Puget , Yea-Lih Lin , Thomas Clouaire , Marion Aguirrebengoa et al.
Nature Communications, 2018, 9 (1), pp.533. ⟨10.1038/s41467-018-02894-w⟩
Journal articles hal-01718514v1
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Des mécanismes moléculaires aux applications cliniques. L’essentiel du Colloque Réplication-Réparation-Recombinaison 2019

Sarah Lambert , Valérie Borde , Jean-Baptiste Charbonnier , Françoise Dantzer , Olivier Espéli et al.
Bulletin du Cancer, 2020, 107 (2), pp.283-287. ⟨10.1016/j.bulcan.2020.01.003⟩
Journal articles hal-03008947v1

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Kyle Miller , Jorrit Tjeertes , Julia Coates , Gaëlle Legube , Sophie Polo et al.
Nature Structural and Molecular Biology, 2010, 17 (9), pp.1144-1151. ⟨10.1038/nsmb.1899⟩
Journal articles hal-03082153v1

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

Jason Iacovoni , Pierre Caron , Imen Lassadi , Estelle Nicolas , Laurent Massip et al.
EMBO Journal, 2010, 29 (8), pp.1446-1457. ⟨10.1038/emboj.2010.38⟩
Journal articles hal-03477027v1
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Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation.

Gaëlle Legube , Laetitia K Linares , Claudie Lemercier , Martin Scheffner , Saadi Khochbin et al.
EMBO Journal, 2002, 21 (7), pp.1704-12. ⟨10.1093/emboj/21.7.1704⟩
Journal articles hal-00379764v1
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Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor

Jean Personnaz , Enzo Piccolo , Alizée Dortignac , Jason Iacovoni , Jérôme J. Mariette et al.
Science Advances , 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Journal articles hal-03624265v1