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Orthogonal Palladium-Catalyzed Direct C−H Bond Arylation of Heteroaromatics with Aryl Halides

Laure Théveau , Cédric Schneider , Corinne Fruit , Christophe Hoarau
ChemCatChem, 2016, 8 (20), pp.3183-3194. ⟨10.1002/cctc.201600489⟩
Journal articles istex hal-02046241v1

Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald–Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol

Joana Campos , Alexandra Pacheco-Benichou , Corinne Fruit , Thierry Besson , Sabine Berteina-Raboin
Synthesis: Journal of Synthetic Organic Chemistry, 2020, ⟨10.1055/s-0040-1707158⟩
Journal articles hal-03001681v1

Three catalysts for activating carbon-hydrogen bonds

Corinne Fruit
Science, 2016, 352 (6291), pp.1277-1278. ⟨10.1126/science.aaf8923⟩
Journal articles hal-02046206v1

Regioselective (hetero)arylation on Azine core via bi-metallic catalysed decarboxylative cross-coupling reaction

Jean-Baptiste Rouchet , Cédric Schneider , Corinne Fruit , Christophe Hoarau
Journées de chimie organique (JCO, 2013), Sep 2013, Palaiseau, France
Poster communications hal-02385175v1

Copper-Catalyzed C–H Arylation of Fused-Pyrimidinone Derivatives Using Diaryliodonium Salts

Alexandra Pacheco-Benichou , Eugénie Ivendengani , Ioannis Kostakis , Thierry Besson , Corinne Fruit
Catalysts, 2021, 11 (1), pp.28. ⟨10.3390/catal11010028⟩
Journal articles hal-03117643v1

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

Rahul Bhansali , Malini Rammohan , Paul Lee , Anouchka Laurent , Qiang Wen , et al.
Journal of Clinical Investigation, 2021, 131 (1), ⟨10.1172/JCI135937⟩
Journal articles hal-03117656v1

Diastereoselective rhodium-catalyzed nitrene transfer starting from chiral sulfonimidamide-derived iminoiodanes

C. Fruit , F. Robert-Peillard , G. Bernardinelli , P. Muller , Rh Dodd , et al.
Tetrahedron: Asymmetry, 2005, 16 N°21, pp.3484-3487
Journal articles hal-00015559v1

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

T.L. Nguyen , Corinne Fruit , Y. Hérault , L. Meijer , Thierry Besson
Expert Opinion on Therapeutic Patents, 2017, 27 (11), pp.1183-1199. ⟨10.1080/13543776.2017.1360285⟩
Journal articles hal-02046302v1

Innovative decarboxylative cross-coupling with azine N-oxides and acrylic acids

Jean-Baptiste Rouchet , Cédric Schneider , Corinne Fruit , Christophe Hoarau
Académie-Industrie chemistry Channel (A-I Chem Channel) closing event, Jan 2015, Rouen, France
Conference papers hal-02378453v1

Pd-catalyzed decarboxylative/dehydropgenative cross-coupling of 2-carboxyazine N-oxides with various (hetero)aryls

Jean-Baptiste Rouchet , Cédric Schneider , Corinne Fruit , Christophe Hoarau
International Symposium on C-H Activation (ISCHA, 2, 2014), Jun 2014, Rennes, France
Poster communications hal-02385155v1

Harnessing a Novel Dyrk1a-Ablim2-MKL1 Regulatory Module in Megakaryocyte Morphogenesis to Enable Scalable Platelet "Pharming

Kamaleldin Elagib , Ashton Brock , Goar Mosoyan , Cara Clementelli , Lorrie Delehanty , et al.
Blood, 2019, 134 (S1), pp.3250-3250. ⟨10.1182/blood-2019-129049⟩
Journal articles hal-02384958v1

A Convenient One‐Pot Preparation of Stable Equivalents of Cyclobutane‐1,2‐dione and Cyclobutanetrione

Geoffrey Deguest , Laurent Bischoff , Corinne Fruit , Francis Marsais
Synthetic Communications, 2008, 38 (6), pp.841-847. ⟨10.1080/00397910701845308⟩
Journal articles hal-02385004v1

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Geoffrey Deguest , Laurent Bischoff , Corinne Fruit , Francis Marsais
Tetrahedron: Asymmetry, 2006, 17 (14), pp.2120-2125. ⟨10.1016/j.tetasy.2006.07.039⟩
Journal articles istex hal-02385048v1

The Chromosome 21 Kinase DYRK1A and Its Substrate FOXO1 Constitute a Novel Therapeutic Pathway in B-ALL

Rahul Bhansali , Malini Rammohan , Ji Heon Paul Lee , Sebastien Malinge , Yi-Chien Tsai , et al.
Blood, 2018, 132 (S1), pp.548-548. ⟨10.1182/blood-2018-99-119854⟩
Journal articles hal-02384966v1

On the racemisation of aspartic anhydride during its preparation

Frédéric Buron , Geoffrey Deguest , Laurent Bischoff , Corinne Fruit , Francis Marsais
Tetrahedron: Asymmetry, 2007, 18 (13), pp.1625-1627. ⟨10.1016/j.tetasy.2007.07.003⟩
Journal articles istex hal-02385023v1

Regioselective (hetero)arylation on Azine core via bi-metallic catalysed decarboxylative cross-coupling reaction

Jean-Baptiste Rouchet , Cédric Schneider , Corinne Fruit , Christophe Hoarau
Journée de l'Ecole doctorale normande de chimie (JEDNC, 2013), Jun 2013, Caen, France
Poster communications hal-02385189v1

Copper-mediated C-H Activation of quinazolinones and thiazoloquinazolinones for the Synthesis of kinase Inhibitors

Corinne Fruit
Séminaire international, Université d'Osaka, Jul 2019, Osaka, Japan
Conference papers hal-02384877v1

Late-Stage Sequential C-H Functionalization of Thiazolo[5,4-f]quina-zolin-9(8H)-one: Synthesis of a Library of Potential Kinase Inhibitors

Corinne Fruit , Florence Couly , Marine Harari , Vincent Levacher , Thierry Besson
International Electronic Conference on Synthetic Organic Chemistry (ECSOC, 20, 2016), Julio A. Seijas Vázquez (coord.), Nov 2016, [online], Spain
Conference papers hal-02383920v1
Image document

Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

Florence Couly , Marine Harari , Carole Dubouilh-Benard , Laëtitia Bailly , Emilie Petit , et al.
Molecules, 2018, 23 (9), pp.2181. ⟨10.3390/molecules23092181⟩
Journal articles hal-02024491v1

Microwave-Assisted Synthesis of Potential Bioactive Benzo-, Pyrido- or Pyrazino-thieno[3,2-d]pyrimidin-4-amine Analogs of MPC-6827

Yvonnick Loidreau , Marie-Renée Nourrisson , Corinne Fruit , Cécile Corbière , Pascal Marchand , et al.
Pharmaceuticals, 2020, 13 (9), pp.202. ⟨10.3390/ph13090202⟩
Journal articles hal-03001666v1

Conception of DYRK1A kinase inhibitors via metal-catalyzed C-H arylation, inspired by fragment-growing studies

Florence Couly , Julien Diharce , Pascal Bonnet , Meijer Laurent , Corinne Fruit , et al.
International Electronic Conference on Medicinal Chemistry (ECMC, 4, 2018), Jean-Jacques Vanden Eynde (coord.), Nov 2018, [online], Belgium. ⟨10.3390/ecmc-4-05580⟩
Conference papers hal-02383907v1

Recent Developments in Microwave-Assisted Metal-Catalyzed C-H Functionalization of Heteroarenes for Medicinal Chemistry and Material Applications

Thierry Besson , Corinne Fruit
Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (22), pp.3879-3889. ⟨10.1055/s-0035-1562608⟩
Journal articles hal-02046186v1

Ligand-free Pd/Cu-catalyzed microwave-assisted C-H arylation of quinazolin-4(3H)-ones with aryl iodides

Marine Harari , Corinne Fruit , Thierry Besson
Semaine d'études en chimie organique (SECO, 52, 2015), May 2015, Morzine, France
Conference papers hal-02378695v1

Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts

Thierry Besson , Corinne Fruit
Pharmaceuticals, 2021, 14 (7), pp.661. ⟨10.3390/ph14070661⟩
Journal articles hal-03358321v1

Design of silicon-based misonidazole analogues and (18)F-radiolabelling.

Pierre Bohn , Abdallah Deyine , Rabah Azzouz , Laetitia Bailly , Catherine Fiol-Petit , et al.
Nuclear Medicine and Biology, 2009, 36 (8), pp.895-905. ⟨10.1016/j.nucmedbio.2009.06.004⟩
Journal articles istex inserm-00467158v1

Late-Stage C-H arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one Backbone: Synthesis of an Array of Potential Kinase Inhibitors

Corinne Fruit
Conférences européennes du Groupement des pharmacochimistes de l'Arc Atlantique (GP2A, 26, 2018), Jun 2018, Asnelles-sur-Mer, France
Conference papers hal-02384639v1

Late-Stage C-H Arylation of Thiazolo[5,4- f ]quinazolin-9(8 H)-one Backbone: Synthesis of an Array of Potential Kinase Inhibitors

Florence Couly , Carole Dubouilh-Benard , Thierry Besson , Corinne Fruit
Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (20), pp.4615-4622. ⟨10.1055/s-0036-1588434⟩
Journal articles hal-02046272v1

Late-Stage C-H Arylation of Bioactive Heterocycles for the Synthesis of Promising Kinases Inhibitors

Corinne Fruit
Séminaire international, Université de Keio, Feb 2020, Tokyo, Japan
Conference papers hal-02541719v1

Late-Stage C-H Arylation of Bioactive Heterocycles for the Synthesis of Promising Kinases Inhibitors

Corinne Fruit
Séminaire international, Université des Sciences d’Okayama, Feb 2020, Okayama, Japan
Conference papers hal-02541724v1

Diaryliodoniums Salts as Coupling Partners for Transition-Metal Catalyzed C- and N-Arylation of Heteroarenes

Alexandra Pacheco-Benichou , Thierry Besson , Corinne Fruit
Catalysts, 2020, 10 (5), pp.483. ⟨10.3390/catal10050483⟩
Journal articles hal-02557380v1