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Characterization of the Tubovesicular Network in Plasmodium vivax Liver Stage Hypnozoites and Schizonts

Kayla Sylvester , Steven P. Maher , Dora Posfai , Michael K. Tran , Mckenna C. Crawford , et al.
Frontiers in Cellular and Infection Microbiology, 2021, 11, pp.687019. ⟨10.3389/fcimb.2021.687019⟩
Journal articles hal-03494752v1

Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment

Rithea Leang , Walter Taylor , Denis Mey Bouth , Lijiang Song , Joel Tarning , et al.
Antimicrobial Agents and Chemotherapy, 2015, 59 (8), pp.4719-4726. ⟨10.1128/AAC.00835-15⟩
Journal articles hal-02560651v1
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Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.

Alona Botnar , Grant Lawrence , Steven Maher , Amélie Vantaux , Benoît Witkowski , et al.
International Journal for Parasitology, 2022, ⟨10.1016/j.ijpara.2022.03.003⟩
Journal articles pasteur-03699213v1
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Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity

Jean Popovici , Camille Roesch , Lenore L. Carias , Nimol Khim , Saorin Kim , et al.
Nature Communications, 2020, 11 (1), pp.953. ⟨10.1038/s41467-020-14574-9⟩
Journal articles pasteur-03494795v1

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

Didier Ménard , Nimol Khim , Johann Beghain , Ayola A Adegnika , Mohammad Shafiul-Alam , et al.
New England Journal of Medicine, 2016, 374 (25), pp.2453-64. ⟨10.1056/NEJMoa1513137⟩
Journal articles pasteur-01336483v1

Identification and characterization of functional human monoclonal antibodies to Plasmodium vivax Duffy-binding protein

L.L. Carias , S. Dechavanne , C.V. Nicolete , S. Sreng , S. Suon , et al.
Journal of Immunology, 2019, 202 (9), p. 2648-2660. ⟨10.4049/jimmunol.1801631⟩
Journal articles hal-02949599v1

Plasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia

Valentine Duru , Benoit Witkowski , Didier Ménard
American Journal of Tropical Medicine and Hygiene, 2016, 95 (6), pp.1228-1238. ⟨10.4269/ajtmh.16-0234⟩
Journal articles hal-02560596v1
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Global analysis of Plasmodium falciparum Na+/H+ exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine

Didier Ménard , Valérie Andriantsoanirina , Nimol Khim , Arsène Ratsimbasoa , Benoit Witkowski , et al.
International Journal for Parasitology, 2013, 3, pp.8-19. ⟨10.1016/j.ijpddr.2012.10.001⟩
Journal articles hal-02560678v1
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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Beatriz Baragaña , Barbara Forte , Ryan Choi , Stephen Nakazawa Hewitt , Juan A. Bueren-Calabuig , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (14), pp.7015 - 7020. ⟨10.1073/pnas.1814685116⟩
Journal articles hal-03494817v1
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In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound.

Anthony Bouillon , David Giganti , Christophe Benedet , Olivier Gorgette , Stéphane Pêtres , et al.
Journal of Biological Chemistry, 2013, 288, pp.18561-73. ⟨10.1074/jbc.M113.456764⟩
Journal articles pasteur-01457905v1

A Plasmodium falciparum gene coding for a 15-kilodalton antigen expressed in asexual stage parasites, gametocytes and gametes

Gordon Langsley , David Kaslow , Patricia Barbot , Thierry Blisnick , Thivi Ponnudurai , et al.
Molecular and Biochemical Parasitology, 1992, 55 (1-2), pp.221-224. ⟨10.1016/0166-6851(92)90143-8⟩
Journal articles istex hal-03246333v1

Echecs thérapeutiques multiples et successifs chez un patient infecté par Plasmodium falciparum au Cambodge et traité par dihydroartémisinine-pipéraquine

B. Witkowski , N. Khim , S. Kim , A. Domergue , V. Duru , et al.
Bulletin de la Société de pathologie exotique , 2016, 109 (2), pp.87-90. ⟨10.1007/s13149-016-0487-4⟩
Journal articles hal-02560628v1

Artemisinin resistance in Plasmodium falciparum

Chanaki Amaratunga , Benoit Witkowski , Nimol Khim , Didier Ménard , Rick M Fairhurst
The Lancet Infectious Diseases, 2014, 14 (6), pp.449-450. ⟨10.1016/S1473-3099(14)70777-7⟩
Journal articles hal-02560674v1

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

Judith Straimer , Nina F. Gnadig , Benoit Witkowski , Chanaki Amaratunga , Valentine Duru , et al.
Science, 2015, 347 (6220), pp.428-431. ⟨10.1126/science.1260867⟩
Journal articles hal-01925134v1
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Studying Land Cover Changes in a Malaria-Endemic Cambodian District: Considerations and Constraints

Anaïs Pepey , Marc Souris , Amélie Vantaux , Serge Morand , Dysoley Lek , et al.
Remote Sensing, 2020, 12 (18), pp.2972. ⟨10.3390/RS12182972⟩
Journal articles hal-02986060v1

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

Benoît Witkowski , Nimol Khim , Pheaktra Chim , Saorin Kim , Sopheakvatey Ke , et al.
Antimicrobial Agents and Chemotherapy, 2013, 57 (2), pp.914-923. ⟨10.1128/AAC.01868-12⟩
Journal articles hal-02378668v1
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Choosing interventions to eliminate forest malaria: preliminary results of two operational research studies inside Cambodian forests

Amber Kunkel , Chea Nguon , Sophea Iv , Srean Chhim , Dom Peov , et al.
Malaria Journal, 2021, 20 (1), pp.51. ⟨10.1186/s12936-020-03572-3⟩
Journal articles pasteur-03494756v1
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Plasmodium copy number variation scan: gene copy numbers evaluation in haploid genomes.

Johann Beghain , Anne-Claire Langlois , Eric Legrand , Laura Grange , Nimol Khim , et al.
Malaria Journal, 2016, 15 (1), pp.206. ⟨10.1186/s12936-016-1258-x⟩
Journal articles pasteur-01303621v1
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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

Laura E de Vries , Patrick a M Jansen , Catalina Barcelo , Justin Munro , Julie M J Verhoef , et al.
Nature Communications, 2022, 13 (1), pp.2158. ⟨10.1038/s41467-022-29688-5⟩
Journal articles pasteur-03699217v1
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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

Frédéric Ariey , Benoit Witkowski , Chanaki Amaratunga , Johann Beghain , Anne-Claire Langlois , et al.
Nature, 2014, 505 (7481), pp.50-5. ⟨10.1038/nature12876⟩
Journal articles pasteur-00921203v1
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Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites.

Alexandre Bougdour , Danièle Maubon , Patricia Baldacci , Philippe Ortet , Olivier Bastien , et al.
Journal of Experimental Medicine, 2009, 206 (4), pp.953-66. ⟨10.1084/jem.20082826⟩
Journal articles hal-00389147v1

In vitro and in vivo properties of ellagic acid in malaria treatment.

Patrice Njomnang Soh , Benoît Witkowski , David Olagnier , Marie-Laure Nicolau , Maria-Concepcion Garcia-Alvarez , et al.
Antimicrobial Agents and Chemotherapy, 2009, 53 (3), pp.1100-6. ⟨10.1128/AAC.01175-08⟩
Journal articles hal-00522424v1
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Use of Plasmodium falciparum culture-adapted field isolates for in vitro exflagellation-blocking assay.

Louis-Jérôme Leba , Lise Musset , Stéphane Pelleau , Yannick Estevez , Caroline Birer , et al.
Malaria Journal, 2015, 14, pp.234. ⟨10.1186/s12936-015-0752-x⟩
Journal articles hal-01182753v1
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Whole Genome Sequencing of Field Isolates Provides Robust Characterization of Genetic Diversity in Plasmodium vivax.

Ernest R Chan , Didier Menard , Peter H David , Arsène Ratsimbasoa , Saorin Kim , et al.
PLoS Neglected Tropical Diseases, 2012, 6 (9), pp.e1811. ⟨10.1371/journal.pntd.0001811⟩
Journal articles pasteur-00741089v1
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Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3

Dora Posfai , Steven P. Maher , Camille Roesch , Amélie Vantaux , Kayla Sylvester , et al.
Cell Chemical Biology, 2020, 27 (6), pp.719-727.e5. ⟨10.1016/j.chembiol.2020.03.009⟩
Journal articles hal-03494788v1
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Structural basis for neutralization of P. vivax by naturally acquired human antibodies that target DBP

Darya Urusova , Lenore Carias , Yining Huang , Vanessa C. Nicolete , Jean Popovici , et al.
Nature Microbiology, 2019, 4 (9), pp.1486 - 1496. ⟨10.1038/s41564-019-0461-2⟩
Journal articles hal-03494812v1
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Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies.

Benoit Witkowski , Chanaki Amaratunga , Nimol Khim , Sokunthea Sreng , Pheaktra Chim , et al.
The Lancet Infectious Diseases, 2013, epub ahead of print. ⟨10.1016/S1473-3099(13)70252-4⟩
Journal articles pasteur-00863935v1

Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism

Lucie Paloque , Benoit Witkowski , Joël Lelièvre , Manel Ouji , Tanila Ben Haddou , et al.
Journal of Antimicrobial Chemotherapy, 2018, 73 (2), pp.395-403. ⟨10.1093/jac/dkx412⟩
Journal articles hal-01963522v1

Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin Sensitivity In Vitro

Chanaki Amaratunga , Benoit Witkowski , Dalin Dek , Vorleak Try , Nimol Khim , et al.
Antimicrobial Agents and Chemotherapy, 2014, 58 (8), pp.4935-4937. ⟨10.1128/AAC.03055-14⟩
Journal articles hal-02560673v1
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Keep the quality high: the benefits of lot testing for the quality control of malaria rapid diagnostic tests

Sandra Incardona , David Bell , Ana Campillo , Jane Cunningham , Frederic Ariey , et al.
Malaria Journal, 2020, 19 (1), pp.247. ⟨10.1186/s12936-020-03324-3⟩
Journal articles pasteur-03274278v1