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Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands

Magali Saez-Ayala , Elsie Yekwa , Mauro Carcelli , Bruno Canard , Karine Alvarez , et al.
International Union of Crystallography journal, 2018, 5 (1), pp.223 - 235. ⟨10.1107/s2052252518001021⟩
Journal articles hal-03078366v1

Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents 1

Oriana Tabarrini , Giuseppe Manfroni , Arnaldo Fravolini , Violetta Cecchetti , Stefano Sabatini , et al.
Journal of Medicinal Chemistry, 2006, 49 (8), pp.2621-2627. ⟨10.1021/jm051250z⟩
Journal articles istex hal-02459231v1

Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets

Sarah Gallois-Montbrun , Yuxing Chen , Hélène Dutartre , Magali Sophys , Solange Moréra , et al.
Molecular Pharmacology, 2003, 63 (3), pp.538-546. ⟨10.1124/mol.63.3.538⟩
Journal articles hal-02459258v1

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

Jan Paeshuyse , Jean-Michel Chezal , Matheus Froeyen , Pieter Leyssen , Hélène Dutartre , et al.
Journal of Virology, 2007, 81 (20), pp.11046-11053. ⟨10.1128/JVI.00388-07⟩
Journal articles hal-02459217v1

Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

Antoine Frangeul , Cécile Bussetta , Jérôme Deval , Karine Barral , Karine Alvarez , et al.
Antiviral Therapy, 2019, 13 (1), pp.115-24
Journal articles hal-02061712v1

In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5'-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives

A. Frangeul , Karine Barral , K. Alvarez , B. Canard
Antimicrobial Agents and Chemotherapy, 2007, 51 (9), pp.3162-3167. ⟨10.1128/AAC.00145-07⟩
Journal articles hal-02061675v1

Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues

Supanee Potisopon , Francois Ferron , Véronique Fattorini , Barbara Selisko , Bruno Canard
Antiviral Research, 2017, 140, pp.25 - 36. ⟨10.1016/j.antiviral.2016.12.021⟩
Journal articles hal-01802946v1

Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors.

Pierre-Marie Allard , Elise Tran Huu Dau , Cécilia Eydoux , Jean-Claude Guillemot , Vincent Dumontet , et al.
Journal of Natural Products, 2011, 74 (11), pp.2446-53. ⟨10.1021/np200715v⟩
Journal articles hal-00684627v1
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The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

L. Delang , C. Li , A. Tas , G. Querat , I. C. Albulescu , et al.
Scientific Reports, 2016, 6, pp.31819. ⟨10.1038/srep31819⟩
Journal articles hal-01439113v1

SPINE bioinformatics and data-management aspects of high-throughput structural biology.

S. Albeck , Pedro Maria Alzari , C. Andreini , L. Banci , I. M. Berry , et al.
Acta crystallographica Section D : Structural biology [1993-..], 2006, 62 (Pt 10), pp.1184-95. ⟨10.1107/S090744490602991X⟩
Journal articles hal-00187834v1

Biodiversity as a source of potent and selective inhibitors of Chikungunya virus replication

Pieter Leyssen , Jacqueline Smadja , Philippe Rasoanaivo , Ameenah Gurib-Fakim , Mohamad Fawzi-Mahomoodally , et al.
Gurib-Fakim, A. Novel Plant Bioresources, Applications in Food, Medicine and Cosmetics,, John Wiley & Sons, Ltd, Chichester UK., pp.151-160, 2014, 978-1-118-46061-0. ⟨10.1002/9781118460566.ch11⟩
Book sections hal-01163238v1

Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain

Magali Saez-Ayala , Elsie Laban Yekwa , Clémence Mondielli , Loic Roux , Sergio Hernández , et al.
Antiviral Research, 2019, 162, pp.79-89. ⟨10.1016/j.antiviral.2018.12.008⟩
Journal articles hal-03076409v1

Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

Karine Barral , Clément Weck , Nadine Payrot , Loic Roux , Céline Durafour , et al.
European Journal of Medicinal Chemistry, 2011, 46 (9), pp.4281-4288. ⟨10.1016/j.ejmech.2011.06.034⟩
Journal articles hal-02061721v1

Expression, purification and crystallization of the SARS-CoV macro domain

Hélène Malet , Karen Dalle , Nicolas Bremond , Fabienne Tocque , Stéphanie Blangy , et al.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2006, 62 (4), pp.405-408. ⟨10.1107/S1744309106009274⟩
Journal articles hal-02066254v1

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Mickaël Bouvet , Adrien Lugari , Clara C. Posthuma , Jessika C. Zevenhoven , Stéphanie Bernard , et al.
Journal of Biological Chemistry, 2014, 289 (37), pp.25783-25796. ⟨10.1074/jbc.M114.577353⟩
Journal articles hal-01910944v1
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Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Barbara Selisko , Nicolas Papageorgiou , Francois Ferron , Bruno Canard
Viruses, 2018, 10 (2), pp.59. ⟨10.3390/v10020059⟩
Journal articles hal-02094550v1
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Observation of arenavirus nucleoprotein heptamer assembly

Nicolas Papageorgiou , Afroditi Vaitsopoulou , Awa Diop , Thi Hong van Nguyen , Bruno Canard , et al.
FEBS Open Bio, 2021, ⟨10.1002/2211-5463.13106⟩
Journal articles hal-03143071v1

Flacourtosides A-F, Phenolic Glycosides Isolated from Flacourtia ramontchi.

Mélanie Bourjot , Pieter Leyssen , Cécilia Eydoux , Jean-Claude Guillemot , Bruno Canard , et al.
Journal of Natural Products, 2012, 75 (4), pp.752-8. ⟨10.1021/np300059n⟩
Journal articles hal-00694429v1

Filovirus proteins for antiviral drug discovery: Structure/function bases of the replication cycle

Baptiste Martin , Bruno Canard , Etienne Decroly
Antiviral Research, 2017, 141, pp.48 - 61. ⟨10.1016/j.antiviral.2017.02.004⟩
Journal articles hal-01802809v1

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Karine Barral , Corinne Sallamand , Christiane Petzold , Bruno Coutard , Axelle Collet , et al.
Antiviral Research, 2013, 99 (3), pp.292-300. ⟨10.1016/j.antiviral.2013.06.001⟩
Journal articles hal-00874640v1
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Primer-Dependent and Primer-Independent Initiation of Double Stranded RNA Synthesis by Purified Arabidopsis RNA-Dependent RNA Polymerases RDR2 and RDR6

Anthony Devert , Nicolas Fabre , Maïna Floris , Bruno Canard , Christophe Robaglia , et al.
PLoS ONE, 2015, 10 (e0120100), ⟨10.1371/journal.pone.0120100.s006⟩
Journal articles hal-01217572v1
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Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Ashleigh Shannon , Barbara Selisko , Nhung-Thi-Tuyet Le , Johanna Huchting , Franck Touret , et al.
Nature Communications, 2020, 11 (1), pp.4682. ⟨10.1038/s41467-020-18463-z⟩
Journal articles inserm-03052188v1
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Snapshots of ADp-ribose bound to Getah virus macro domain reveal an intriguing choreography

Ana Sofia Ferreira-Ramos , Gerlind Sulzenbacher , Bruno Canard , Bruno Coutard
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-70870-w⟩
Journal articles hal-03160433v1

Drugs against SARS‐CoV ‐2: What do we know about their mode of action?

Coralie Valle , Baptiste Martin , Franck Touret , Ashleigh Shannon , Bruno Canard , et al.
Reviews in Medical Virology, 2020, 30 (6), pp.1-10. ⟨10.1002/rmv.2143⟩
Journal articles hal-03030758v1
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The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz , Sergey Tcherniuk , Nina Ysebaert , Pravien Abeywickrema , Mathieu Noël , et al.
PLoS Pathogens, 2021, 17 (5), pp.e1009562. ⟨10.1371/journal.ppat.1009562⟩
Journal articles hal-03352803v1

Chemical constituents of Anacolosa pervilleana and their antiviral activities.

Mélanie Bourjot , Pieter Leyssen , Cécilia Eydoux , Jean-Claude Guillemot , Bruno Canard , et al.
Fitoterapia, 2012, 83 (6), pp.1076-1080. ⟨10.1016/j.fitote.2012.05.004⟩
Journal articles istex hal-00722062v1

Preparation of purine and pyrimidine acyclic nucleotide analogs as antiviral agents

Karine Barral , Bruno Canard , Karine Alvarez , Jean-Louis Romette , Johan Neyts , et al.
France, Patent n° : WO 2007-IB4233. 2007
Patents hal-02063281v1
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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Natacha S Ogando , Francois Ferron , Etienne Decroly , Bruno Canard , Clara C Posthuma , et al.
Frontiers in Microbiology, 2019, 10, ⟨10.3389/fmicb.2019.01813⟩
Journal articles hal-02353805v1

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

H. Malet , B. Coutard , S. Jamal , H. Dutartre , N. Papageorgiou , et al.
Journal of Virology, 2009, 83 (13), pp.6534-6545. ⟨10.1128/JVI.00189-09⟩
Journal articles hal-02459209v1

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

D. Topalis , K. Alvarez , K. Barral , Hélène Munier-Lehmann , B. Schneider , et al.
Nucleosides, Nucleotides and Nucleic Acids, 2008, 27 (4), pp.319-31. ⟨10.1080/15257770801941952⟩
Journal articles pasteur-00316017v1