Search - Archive ouverte HAL Access content directly

Filter your results

113 Results
Image document

Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.

Benjamin Dehay , Deniz Dalkara , Sandra Dovero , Qin Li , Erwan Bezard
Scientific Reports, 2012, 2, pp.253. ⟨10.1038/srep00253⟩
Journal articles hal-01053467v1
Image document

Critical Role of the Proline-rich Region in Huntingtin for Aggregation and Cytotoxicity in Yeast

Benjamin Dehay , Anne Bertolotti
Journal of Biological Chemistry, 2006, 281 (47), pp.35608-35615. ⟨10.1074/jbc.M605558200⟩
Journal articles inserm-02439167v1
Image document

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

Mathieu Bourdenx , Sandra Dovero , Michel Engeln , Simone Bido , Matthieu Bastide , et al.
Acta Neuropathologica Communications, 2015, 3, pp.46. ⟨10.1186/s40478-015-0222-2⟩
Journal articles inserm-02439376v1
Image document

Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy

Miguel Lopez‐cuina , Paul Guerin , Marie‐hélène Canron , Anna Delamarre , Benjamin Dehay , et al.
Movement Disorders, 2020, 35 (7), pp.1163-1172. ⟨10.1002/mds.28034⟩
Journal articles inserm-03285176v1
Image document

Efficient Generation of A9 Midbrain Dopaminergic Neurons by Lentiviral Delivery of LMX1A in Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

A. Sánchez-Danés , A. Consiglio , Y. Richaud , I. Rodríguez-Pizà , B. Dehay , et al.
Human Gene Therapy, 2012, 23 (1), pp.56-69. ⟨10.1089/hum.2011.054⟩
Journal articles inserm-02439199v1

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

B. Dehay , A. Ramirez , M. Martinez-Vicente , C. Perier , M.-H. Canron , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (24), ⟨10.1073/pnas.1112368109⟩
Journal articles hal-01290058v1

Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates

Alexander Maxan , Giacomo Sciacca , Melanie Alpaugh , Zhu Tao , Ludivine Breger , et al.
Neurobiology of Disease, 2020, pp.104951. ⟨10.1016/j.nbd.2020.104951⟩
Journal articles inserm-02615641v1

Experimental modelling of -synuclein aggregation and spreading in synucleinopathies.

Mathieu Bourdenx , Benjamin Dehay , Erwan Bezard'
Bulletin de l'Académie Nationale de Médecine, 2015, 199 (6), pp.797-808
Journal articles inserm-02448823v1

Single-molecule approach to find out toxic oligomeric alpa-synuclein species formation

Benjamin Dehay
Movement Disorders, 2012, 27 (12), pp.1493-1493. ⟨10.1002/mds.25180⟩
Journal articles istex inserm-02439334v1

Evidence piles Up for prion-like propagation mechanisms in synucleinopathies

Benjamin Dehay
Movement Disorders, 2014, 29 (2), pp.187-187. ⟨10.1002/mds.25793⟩
Journal articles istex inserm-02439341v1
Image document

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity

Daniel Ysselstein , Benjamin Dehay , Isabel Costantino , George Mccabe , Matthew P Frosch , et al.
Acta Neuropathologica Communications, 2017, 5 (3), ⟨10.1186/s40478-016-0403-7⟩
Journal articles inserm-02439417v1
Image document

Checking behavior in rhesus monkeys is related to anxiety and frontal activity

Marion Bosc , Bernard Bioulac , Nicolas Langbour , Tho Hai Nguyen , Michel Goillandeau , et al.
Scientific Reports, 2017, 7, pp.45267. ⟨10.1038/srep45267⟩
Journal articles inserm-02439427v1
Image document

Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

Céline Perier , Jordi Bové , Du-Chu Wu , Benjamin Dehay , Dong-Kug Choi , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (19), pp.8161-8166. ⟨10.1073/pnas.0609874104⟩
Journal articles inserm-02439178v1

Pathogenic Lysosomal Depletion in Parkinson's Disease

Benjamin Dehay , Jordi Bové , Natalia Rodriguez-Muela , Céline Perier , Adriana Recasens , et al.
Journal of Neuroscience, 2010, 30 (37), pp.12535-12544. ⟨10.1523/JNEUROSCI.1920-10.2010⟩
Journal articles inserm-02439185v1
Image document

L-DOPA Impairs Proteasome Activity in Parkinsonism through D1 Dopamine Receptor

Amandine Berthet , Erwan Bézard , Gregory Porras , Stefania Fasano , Pedro Barroso-Chinea , et al.
Journal of Neuroscience, 2012, 32 (2), pp.681-691. ⟨10.1523/JNEUROSCI.1541-11.2012⟩
Journal articles inserm-02439205v1

Nanoparticles restore lysosomal acidification defects: Implication for Parkinson and other lysosomal-related diseases.

Mathieu Bourdenx , Jonathan Daniel , Emilie Genin , Federico N Soria , Mireille Blanchard-Desce , et al.
Autophagy, 2016
Journal articles hal-01287766v1

Lysosomal dysfunction in Parkinson disease

Benjamin Dehay , Marta Martinez-Vicente , Alfredo Ramirez , Celine Perier , Christine Klein , et al.
Autophagy, 2012, 8 (9), ⟨10.4161/auto.21011⟩
Journal articles hal-01290069v1
Image document

Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE

Xiuping Sun , Xuan Yu , Ling Zhang , Wenjie Zhao , Manshi Wang , et al.
Heliyon, 2021, 7 (2), pp.e06302. ⟨10.1016/j.heliyon.2021.e06302⟩
Journal articles inserm-03154753v1
Image document

Involvement of Autophagy in Levodopa‐Induced Dyskinesia

Michael Feyder , Carina Plewnia , Ori Lieberman , Giada Spigolon , Alessandro Piccin , et al.
Movement Disorders, 2021, Online ahead of print. ⟨10.1002/mds.28480⟩
Journal articles inserm-03114552v1

U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells

Mathieu Schmitt , Benjamin Dehay , Erwan Bézard , F. Javier Garcia-Ladona
Synapse, 2017, 71 (9), pp.e21980. ⟨10.1002/syn.21980⟩
Journal articles inserm-02439437v1

In vivo models of alpha-synuclein transmission and propagation

Ariadna Recasens , Ayse Ulusoy , Philipp Kahle , Donato Di Monte , Benjamin Dehay
Cell and Tissue Research, 2018, 373 (1), pp.183-193. ⟨10.1007/s00441-017-2730-9⟩
Journal articles inserm-02439484v1
Image document

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

Mathieu Bourdenx , Erwan Bézard , Benjamin Dehay
Frontiers in Neuroanatomy, 2014, 8, pp.83. ⟨10.3389/fnana.2014.00083⟩
Journal articles inserm-02439359v1

Autophagie et cerveau

Mathieu Bourdenx , Benjamin Dehay
Médecine/Sciences, 2017, 33 (3), pp.268-274. ⟨10.1051/medsci/20173303013⟩
Journal articles inserm-02439431v1

Exosomes, an Unmasked Culprit in Neurodegenerative Diseases.

Federico N Soria , Olatz Pampliega , Mathieu Bourdenx , Wassilios G Meissner , Erwan Bezard , et al.
Frontiers in Neuroscience, 2017, 11, pp.26. ⟨10.3389/fnins.2017.00026⟩
Journal articles hal-01490842v1

New animal models of Parkinson's disease.

Benjamin Dehay , Erwan Bezard
Movement Disorders, 2011, 26 (7), pp.1198-1205
Journal articles hal-01290753v1

Nucleolipid Acid-Based Nanocarriers Restore Neuronal Lysosomal Acidification Defects

Mathias Brouillard , Philippe Barthélémy , Benjamin Dehay , Sylvie Crauste-Manciet , Valérie Desvergnes
Frontiers in Chemistry, 2021, 9, ⟨10.3389/fchem.2021.736554⟩
Journal articles hal-03363467v1
Image document

Systemic Gene Delivery by Single-Dose Intracardiac Administration of scAAV2/9 and scAAV2/rh10 Variants in Newborn Rats

Lucie Chansel-Debordeaux , Mathieu Bourdenx , Nathalie Dutheil , Sandra Dovero , Marie-Helene Canron , et al.
Human gene therapy methods, 2018, 29 (4), pp.189-199. ⟨10.1089/hgtb.2017.192.r3⟩
Journal articles inserm-02439491v1
Image document

Lack of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment

Morgane Darricau , Marie-Hélène Canron , Marion Bosc , Marie-Laure Arotçarena , Mégane Le Quang , et al.
Neurobiology of Aging, 2021, ⟨10.1016/j.neurobiolaging.2021.07.009⟩
Journal articles inserm-03297050v1
Image document

Identification of distinct pathological signatures induced by patient-derived -synuclein structures in nonhuman primates

M. Bourdenx , A. Nioche , S. Dovero , M.-L. Arotcarena , S. Camus , et al.
Science Advances , 2020, 6 (20), ⟨10.1126/sciadv.aaz9165⟩
Journal articles hal-03403421v1

Modulating Lysosomal pH through Innovative Multimerized Succinic Acid-Based Nucleolipid Derivatives

Mathias Brouillard , Rémi Kinet , Marie Joyeux , Benjamin Dehay , Sylvie Crauste-Manciet , et al.
Bioconjugate Chemistry, 2023, 34 (3), pp.572-580. ⟨10.1021/acs.bioconjchem.3c00041⟩
Journal articles inserm-04009308v1