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Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity

Louis S. Ates , Anzaan Dippenaar , Fadel Sayes , Alexandre Pawlik , Christiane Bouchier et al.
Genome Biology and Evolution, 2018, 10 (8), pp.1858 - 1874. ⟨10.1093/gbe/evy145⟩
Journal articles hal-01884644v1

Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus

Alexandre Pawlik , Guillaume Garnier , Mickael Orgeur , Pin Tong , Amanda Lohan et al.
Molecular Microbiology, 2013, 90 (3), pp.612-629. ⟨10.1111/mmi.12387⟩
Journal articles pasteur-02618774v1
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A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity

Jodie Lopez , François Anna , Pierre Authié , Alexandre Pawlik , Min-Wen Ku et al.
Cell Reports, 2022, 40 (4), pp.111142. ⟨10.1016/j.celrep.2022.111142⟩
Journal articles pasteur-03909608v1
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Lsr2 Is an Important Determinant of Intracellular Growth and Virulence in Mycobacterium abscessus

Vincent Le Moigne , Audrey Bernut , Mélanie Cortes , Albertus Viljoen , Christian Dupont et al.
Frontiers in Microbiology, 2019, 10, pp.905. ⟨10.3389/fmicb.2019.00905⟩
Journal articles pasteur-02618218v1

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

J. Gonzalo-Asensio , W. Malaga , Alexandre Pawlik , Catherine Astarie-Dequeker , C. Passemar et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (31), pp.11491-11496. ⟨10.1073/pnas.1406693111⟩
Journal articles hal-02325922v1

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

Eva C. Boritsch , Varun Khanna , Alexandre Pawlik , Nadine Honoré , Victor Navas et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (35), pp.9876-9881. ⟨10.1073/pnas.1604921113⟩
Journal articles pasteur-02618520v1

Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells

Béatrice Jacquelin , Thierry Kortulewski , Pierre Vaigot , Alexandre Pawlik , Gaëtan Gruel et al.
Blood, 2005, 106 (6), pp.1965-1974. ⟨10.1182/blood-2004-10-3975⟩
Journal articles pasteur-02618902v1
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Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

Philip Supply , Michael Marceau , Sophie Mangenot , David Roche , Carine Rouanet et al.
Nature Genetics, 2013, 45 (2), pp.172-179. ⟨10.1038/ng.2517⟩
Journal articles pasteur-02615220v1

A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component

Luis Solans , Nacho Aguiló , Sofia Samper , Alexandre Pawlik , Wafa Frigui et al.
Infection and Immunity, 2014, 82 (8), pp.3446-3456. ⟨10.1128/iai.01824-14⟩
Journal articles pasteur-02618736v1
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Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages

Violaine Dubois , Alexandre Pawlik , Anouchka Bories , Vincent Le Moigne , Odile Sismeiro et al.
PLoS Pathogens, 2019, 15 (11), pp.e1008069. ⟨10.1371/journal.ppat.1008069⟩
Journal articles hal-02379161v1

From environmental bacteria to obligate human pathogen: adaptations associated with the emergence of tuberculosis bacilli

Delphine Payros , Wladimir Malaga , Alexandre Pawlik , Serge Mazères , Céline Berrone et al.
EMBO Workshop. Pathogen immunity and signalling., Apr 2019, Oxford, United Kingdom
Conference papers hal-02341937v1

Transcriptome Characterization Uncovers the Molecular Response of Hematopoietic Cells to Ionizing Radiation

Alexandre Pawlik , Olivier Alibert , Sylvain Baulande , Pierre Vaigot , Diana Tronik-Le Roux et al.
Radiation Research, 2011, 175 (1), pp.66-82. ⟨10.1667/rr2282.1⟩
Journal articles pasteur-02618854v1

The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis

Nawel Slama , Stevie Jamet , Wafa Frigui , Alexandre Pawlik , Daria Bottai et al.
Molecular Microbiology, 2016, 99 (4), pp.794-807. ⟨10.1111/mmi.13266⟩
Journal articles pasteur-02618562v1
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De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

Thomas Laval , Laura Pedró-Cos , Wladimir Malaga , Laure Guenin-Macé , Alexandre Pawlik et al.
eLife, 2021, 10, pp.e71946. ⟨10.7554/eLife.71946⟩
Journal articles pasteur-03534651v1

A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus

Christian Dupont , Albertus Viljoen , Faustine Dubar , Mickaël Blaise , Audrey Bernut et al.
Molecular Microbiology, 2016, 101 (3), pp.515-529. ⟨10.1111/mmi.13406⟩
Journal articles hal-02137602v1
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Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection.

Matthias I Gröschel , Fadel Sayes , Sung Jae Shin , Wafa Frigui , Alexandre Pawlik et al.
Cell Reports, 2017, 18 (11), pp.2752-2765. ⟨10.1016/j.celrep.2017.02.057⟩
Journal articles pasteur-01503927v1

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Violaine Dubois , Laura Laencina , Anouchka Bories , Vincent Le Moigne , Alexandre Pawlik et al.
Journal of visualized experiments : JoVE, 2018, 139, pp.57766. ⟨10.3791/57766⟩
Journal articles pasteur-02618229v1

Changes in transcriptome after in vivo exposure to ionising radiation reveal a highly specialised liver response

Alexandre Pawlik , Paul Delmar , Sebastien Bosse , Laurie Sainz , Cyrille Petat et al.
International Journal of Radiation Biology, 2009, 85 (8), pp.656-671. ⟨10.1080/09553000903020024⟩
Journal articles pasteur-02618874v1

Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants

Anne-Laure Roux , Aurélie Ray , Alexandre Pawlik , Halima Medjahed , Gilles Etienne et al.
Cellular Microbiology, 2011, 13 (5), pp.692-704. ⟨10.1111/j.1462-5822.2010.01565.x⟩
Journal articles pasteur-02618829v1

Novel Microarray-Based Method for Estimating Exposure to Ionizing Radiation

Gaëtan Gruel , Carlo Lucchesi , Alexandre Pawlik , Vincent Frouin , Olivier Alibert et al.
Radiation Research, 2006, 166 (5), pp.746-756. ⟨10.1667/rr0260.1⟩
Journal articles pasteur-02618889v1
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Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis

Fabien Le Chevalier , Alessandro Cascioferro , Wafa Frigui , Alexandre Pawlik , Eva C. Boritsch et al.
Scientific Reports, 2015, 5 (1), pp.16918. ⟨10.1038/srep16918⟩
Journal articles pasteur-02618632v1
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Pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

Eva C. Boritsch , Wafa Frigui , Alessandro Cascioferro , Wladimir Malaga , Gilles Etienne et al.
Nature Microbiology, 2016, 1 (février 2016), ⟨10.1038/nmicrobiol.2015.19⟩
Journal articles pasteur-01265519v1
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Pathogenomic analyses of Mycobacterium microti, an ESX-1-deleted member of the Mycobacterium tuberculosis complex causing disease in various hosts

Mickael Orgeur , Wafa Frigui , Alexandre Pawlik , Simon Clark , Ann Williams et al.
Microbial Genomics, 2021, 7 (2), ⟨10.1099/mgen.0.000505⟩
Journal articles pasteur-03255655v1
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TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages

Daria Bottai , Wafa Frigui , Fadel Sayes , Mariagrazia Di Luca , Dalila Spadoni et al.
Nature Communications, 2020, 11 (1), pp.684. ⟨10.1038/s41467-020-14508-5⟩
Journal articles pasteur-02473990v1
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CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Fadel Sayes , Alexandre Pawlik , Wafa Frigui , Matthias I Gröschel , Samuel Crommelynck et al.
PLoS Pathogens, 2016, 12 (7), pp.e1005770. ⟨10.1371/journal.ppat.1005770⟩
Journal articles pasteur-02615226v1
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Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli

Aideen C Allen , Wladimir Malaga , Cyril Gaudin , Arnaud Volle , Flavie Moreau et al.
Nature Microbiology, 2021, 6 (8), pp.1082-1093. ⟨10.1038/s41564-021-00938-4⟩
Journal articles hal-03318178v1
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Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis

Laleh Majlessi , Fadel Sayes , Jean-François Bureau , Alexandre Pawlik , Valérie Michel et al.
Mucosal Immunology, 2017, 10 (5), pp.1178 - 1189. ⟨10.1038/mi.2016.140⟩
Journal articles hal-01652031v1