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Pré-Publication, Document De Travail Année : 2023

MiniBAR/KIAA0355 is a dual Rac and Rab effector required for ciliogenesis

Audrey Salles
Olena Pylypenko

Résumé

Cilia protrude from the cell surface and play critical roles in in-tracellular signaling, environmental sensing and development. Actin-dependent contractility and intracellular trafficking are both required for ciliogenesis, but little is known about how these processes are coordinated. Here, we identified a Rac1-and Rab35-binding protein with a truncated BAR domain that we named MiniBAR (aka KIAA0355/GARRE) which plays a key role in ciliogenesis. MiniBAR colocalizes with Rac1 and Rab35 at the plasma membrane and on intracellular vesicles traffick-ing to the ciliary base and exhibits remarkable fast pulses at the ciliary membrane. MiniBAR depletion leads to short cilia resulting from abnormal Rac-GTP/Rho-GTP levels, increased acto-myosin-II-dependent contractility together with defective trafficking of IFT88 and ARL13B into cilia. MiniBAR-depleted zebrafish embryos display dysfunctional short cilia and hall-marks of ciliopathies including left-right asymmetry defects. Thus, MiniBAR is a unique dual Rac and Rab effector that con-trols both actin cytoskeleton and membrane trafficking for cili-ogenesis.
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pasteur-04288644 , version 1 (16-11-2023)

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Copyright (Tous droits réservés)

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Ronan Shaughnessy, Murielle Serres, Sophie Escot, Hussein Hammich, Frédérique Cuvelier, et al.. MiniBAR/KIAA0355 is a dual Rac and Rab effector required for ciliogenesis. 2023. ⟨pasteur-04288644⟩
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