Molecular epidemiology of hepatitis C virus in Cambodia during 2016–2017 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2019

Molecular epidemiology of hepatitis C virus in Cambodia during 2016–2017

Résumé

In Cambodia, little epidemiological data of hepatitis C virus (HCV) is available. All previous studies were limited to only small or specific populations. In the present study, we performed a characterization of HCV genetic diversity based on demography, clinical data, and phylogenetic analysis of HCV nonstructural 5B (NS5B) sequences belonging to a large cohort of patients (n = 3,133) coming from majority part of Cambodia between September 2016 and December 2017. The phylogenetic analysis revealed that HCV genotype 1 and 6 were the most predominant and sharing equal proportions (46%). The remaining genotypes were genotype 2 (4.3%) and unclassified variants (3.6%). Among genotype 1, subtype 1b was the most prevalent subtype accounting for 94%. Within genotype 6, we observed a high degree of diversity and the most common viral subtypes were 6e (44%) and 6r (23%). This characteristic points to the longstanding history of HCV in Cambodia. Geographic specificity of viral genotype was not observed. Risks of HCV infection were mainly associated with experience of an invasive medical procedure (64.7%), having partner with HCV (19.5%), and blood transfusion (9.9%). In addition, all of these factors were comparable among different HCV genotypes. All these features define the specificity of HCV epidemiology in Cambodia.

Domaines

Virologie
Fichier principal
Vignette du fichier
Nouhin et al. - 2019 - Molecular epidemiology of hepatitis C virus in Cam.pdf (1.77 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

pasteur-03214748 , version 1 (02-05-2021)

Licence

Paternité

Identifiants

Citer

Janin Nouhin, Momoko Iwamoto, Sophearot Prak, Jean-Philippe Dousset, Kerya Phon, et al.. Molecular epidemiology of hepatitis C virus in Cambodia during 2016–2017. Scientific Reports, 2019, 9 (1), pp.7314. ⟨10.1038/s41598-019-43785-4⟩. ⟨pasteur-03214748⟩
27 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More