Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Blood Année : 2005

Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells

Résumé

Our knowledge of the molecular mechanisms that regulate hematopoiesis in physiologic and pathologic conditions is limited. Using a molecular approach based on cDNA microarrays, we demonstrated the emergence of an alternative pathway for mature bone marrow cell recovery after the programmed and reversible eradication of CD41+ cells in transgenic mice expressing a conditional toxigene targeted by the platelet alphaIIb promoter. The expression profile of the newly produced CD41+ cells showed high levels of transcripts encoding Ezh2, TdT, Rag2, and various immunoglobulin (Ig) heavy chains. In this context, we identified and characterized a novel population of Lin-Sca-1hi c-Kit- cells, with a lymphoid-like expression pattern, potentially involved in the reconstitution process. Our study revealed novel transcriptional cross talk between myeloid and lymphoid lineages and identified gene expression modifications that occur in vivo under these particular stress conditions, opening important prospects for therapeutic applications.

Dates et versions

pasteur-02618902 , version 1 (25-05-2020)

Identifiants

Citer

Béatrice Jacquelin, Thierry Kortulewski, Pierre Vaigot, Alexandre Pawlik, Gaëtan Gruel, et al.. Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin αIIb-expressing cells. Blood, 2005, 106 (6), pp.1965-1974. ⟨10.1182/blood-2004-10-3975⟩. ⟨pasteur-02618902⟩

Collections

CEA JACOB CEA-DRF
7 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More