Autism spectrum disorder - Archive ouverte HAL Access content directly
Journal Articles Nature reviews Disease primers Year : 2020

Autism spectrum disorder

Abstract

Autism spectrum disorder is a construct used to describe individuals with a specific combination of impairments in social communication and repetitive behaviours, highly restricted interests and/or sensory behaviours beginning early in life. The worldwide prevalence of autism is just under 1%, but estimates are higher in high-income countries. Although gross brain pathology is not characteristic of autism, subtle anatomical and functional differences have been observed in post-mortem, neuroimaging and electrophysiological studies. Initially, it was hoped that accurate measurement of behavioural phenotypes would lead to specific genetic subtypes, but genetic findings have mainly applied to heterogeneous groups that are not specific to autism. Psychosocial interventions in children can improve specific behaviours, such as joint attention, language and social engagement, that may affect further development and could reduce symptom severity. However, further research is necessary to identify the long-term needs of people with autism, and treatments and the mechanisms behind them that could result in improved independence and quality of life over time. Families are often the major source of support for people with autism throughout much of life and need to be considered, along with the perspectives of autistic individuals, in both research and practice.
Fichier principal
Vignette du fichier
NRDP-19-060 Autism spectrum disorder.pdf (1.04 Mo) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

pasteur-02445082 , version 1 (19-01-2020)

Identifiers

Cite

Catherine Lord, Traolach Brugha, Tony Charman, James Cusack, Guillaume Dumas, et al.. Autism spectrum disorder. Nature reviews Disease primers, 2020, 6 (1), pp.5. ⟨10.1038/s41572-019-0138-4⟩. ⟨pasteur-02445082⟩
4692 View
7499 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More