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Article Dans Une Revue Nature Cell Biology Année : 2016

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network

Résumé

Pluripotent mouse embryonic stem cells maintain their identity throughout virtually infinite cell divisions. This phenomenon, referred to as self-renewal, depends on a network of sequence-specific transcription factors (TFs) and requires daughter cells to accurately reproduce the gene expression pattern of the mother. However, dramatic chromosomal changes take place in mitosis, generally leading to the eviction of TFs from chromatin. Here, we report that Esrrb, a major pluripotency TF, remains bound to key regulatory regions during mitosis. We show that mitotic Esrrb binding is highly dynamic, driven by specific recognition of its DNA-binding motif and is associated with early transcriptional activation of target genes after completion of mitosis. These results indicate that Esrrb may act as a mitotic bookmarking factor, opening another perspective to molecularly understand the role of sequence-specific TFs in the epigenetic control of self-renewal, pluripotency and genome reprogramming.
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pasteur-01972743 , version 1 (07-01-2019)

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Paternité - Pas d'utilisation commerciale - Partage selon les Conditions Initiales

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Nicola Festuccia, Agnès Dubois, Sandrine Vandormael-Pournin, Elena Gallego Tejeda, Adrien Mouren, et al.. Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network. Nature Cell Biology, 2016, 18 (11), pp.1139-1148. ⟨10.1038/ncb3418⟩. ⟨pasteur-01972743⟩
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