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Journal Articles Journal of Biological Chemistry Year : 2016

Selenoprotein Gene Nomenclature

1 HMS - Harvard Medical School [Boston]
2 BROAD INSTITUTE - Broad Institute of MIT and Harvard
3 Karolinska Institutet [Stockholm]
4 UHM - University of Hawai‘i [Mānoa]
5 DIfE - German Institute of Human Nutrition Potsdam-Rehbrücke
6 EMBL-EBI - European Bioinformatics Institute [Hinxton]
7 Vanderbilt University School of Medicine [Nashville]
8 NIH - National Institutes of Health [Bethesda]
9 Max Planck Institute for Evolutionary Anthropology [Leipzig]
10 REVE - Expression de l'ARN chez les virus et les eucaryotes - RNA Expression in Viruses and Eukaryotes
11 IDG - Institute for Developmental Genetics [Neuherberg]
12 RWJMS - Robert Wood Johnson Medical School [Piscataway, NJ]
13 UIC - University of Illinois [Chicago]
14 Cleveland Clinic
15 BFA (UMR_8251 / U1133) - Unité de Biologie Fonctionnelle et Adaptative
16 CHU Pitié-Salpêtrière [AP-HP]
17 UDELAR - Universidad de la República [Montevideo]
18 Unipd - Università degli Studi di Padova = University of Padua
19 University of Manchester [Manchester]
20 CRG - Centre for Genomic Regulation - Centre de Regulació Genòmica [Barcelona]
21 Newcastle University [Newcastle]
22 University of Vermont [Burlington]
23 University of Utah
24 HUST - Huazhong University of Science and Technology [Wuhan]
25 Yeungnam University [South Korea]
26 Korea University [Seoul]
27 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
28 ARN - Architecture et Réactivité de l'ARN
29 KSQ Therapeutics [Cambridge MA]
30 SNU - Seoul National University [Seoul]
31 Cornell University [New York]
32 Shenzhen University [Shenzhen]
33 Penn State - Pennsylvania State University
34 UNIS - University of Surrey
35 University of Delaware [Newark]
36 Instituto de Higiene [Montevideo]
37 MSU - Montana State University
38 Rheinische Friedrich-Wilhelms-Universität Bonn
39 University of Wisconsin-Madison
40 Towson University [Towson, MD, United States]
41 OSU - Oregon State University
Alain Krol
  • Function : Author
  • PersonId : 849718
Byung Cheon Lee
Qiong Liu
  • Function : Author
  • PersonId : 915493
Alain Lescure
Marco Mariotti
Yan Zhang


The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV), and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
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Origin : Publication funded by an institution

Dates and versions

pasteur-01882353 , version 1 (27-05-2021)





Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Regina Brigelius-Flohé, Elspeth A. Bruford, et al.. Selenoprotein Gene Nomenclature. Journal of Biological Chemistry, 2016, 291 (46), pp.24036 - 24040. ⟨10.1074/jbc.M116.756155⟩. ⟨pasteur-01882353⟩
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