Synthetic lethality between PAXX and XLF in mammalian development. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Genes and Development Année : 2016

Synthetic lethality between PAXX and XLF in mammalian development.

Résumé

PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf −/− mice, Paxx −/− mice are viable, grow normally , and are fertile but show mild radiosensitivity. Strikingly, while Paxx loss is epistatic with Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability , cell death in the central nervous system, and an almost complete block in lymphogenesis, phenotypes that closely resemble those of Xrcc4 −/− and Lig4 −/− mice. Thus, combined loss of Paxx and Xlf is synthetic-lethal in mammals.
Fichier principal
Vignette du fichier
Genes Dev.-2016-Balmus-2152-7.pdf (714.17 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

pasteur-01416628 , version 1 (14-12-2016)

Licence

Paternité

Identifiants

Citer

Gabriel Balmus, Ana C. Barros, Paul W.G. Wijnhoven, Chloé Lescale, Hélène P Lenden Hasse, et al.. Synthetic lethality between PAXX and XLF in mammalian development.. Genes and Development, 2016, 30 (19), pp.2152 - 2157. ⟨10.1101/gad.290510.116⟩. ⟨pasteur-01416628⟩

Collections

PASTEUR USPC
148 Consultations
287 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More