Structural basis of potent Zika–dengue virus antibody cross-neutralization - Archive ouverte HAL Access content directly
Journal Articles Nature Year : 2016

Structural basis of potent Zika–dengue virus antibody cross-neutralization

Van-Mai Cao-Lormeau
Félix A. Rey
  • Function : Author
  • PersonId : 860354


Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue virus infections.
Fichier principal
Vignette du fichier
Structural basis of Zika and Dengue virus potent antibody cross neutralization.pdf (3.48 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-01408100 , version 1 (03-04-2019)


Attribution - NonCommercial - ShareAlike



Giovanna Barba-Spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie-Christine Vaney, Iris Medits, et al.. Structural basis of potent Zika–dengue virus antibody cross-neutralization. Nature, 2016, 536 (7614), pp.48 - 53. ⟨10.1038/nature18938⟩. ⟨pasteur-01408100⟩
1411 View
736 Download



Gmail Facebook X LinkedIn More