<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of pasteur-00167019</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T05:15:10+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The highways and byways of prion protein trafficking.</title>
            <author role="aut">
              <persName>
                <forename type="first">Vincenza</forename>
                <surname>Campana</surname>
              </persName>
              <idno type="halauthorid">222450-0</idno>
              <affiliation ref="#struct-462726"/>
              <affiliation ref="#struct-41988"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daniela</forename>
                <surname>Sarnataro</surname>
              </persName>
              <idno type="idhal" notation="numeric">758454</idno>
              <idno type="halauthorid" notation="string">222452-758454</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6094-8384</idno>
              <affiliation ref="#struct-41988"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chiara</forename>
                <surname>Zurzolo</surname>
              </persName>
              <email type="md5">176d2d33334e3a340cc5551b5add841f</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="string">chiara-zurzolo</idno>
              <idno type="idhal" notation="numeric">746960</idno>
              <idno type="halauthorid" notation="string">4971-746960</idno>
              <idno type="IDREF">https://www.idref.fr/11602075X</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6048-6602</idno>
              <affiliation ref="#struct-462726"/>
              <affiliation ref="#struct-41988"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Christiane</forename>
                <surname>Goisnard</surname>
              </persName>
              <email type="md5">47e9ba613cd3dd92b058a58331201dea</email>
              <email type="domain">aol.com</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2007-08-14 09:51:31</date>
              <date type="whenModified">2025-08-29 16:12:03</date>
              <date type="whenReleased">2007-08-14 14:43:46</date>
              <date type="whenProduced">2005-02</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/6H6-KRXSXR6H-J/fulltext.pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="120032">
                <persName>
                  <forename>Christiane</forename>
                  <surname>Goisnard</surname>
                </persName>
                <email type="md5">47e9ba613cd3dd92b058a58331201dea</email>
                <email type="domain">aol.com</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">pasteur-00167019</idno>
            <idno type="halUri">https://pasteur.hal.science/pasteur-00167019</idno>
            <idno type="halBibtex">campana:pasteur-00167019</idno>
            <idno type="halRefHtml">&lt;i&gt;Trends in Cell Biology&lt;/i&gt;, 2005, 15 (2), pp.102-11. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.tcb.2004.12.002"&gt;&amp;#x27E8;10.1016/j.tcb.2004.12.002&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Trends in Cell Biology, 2005, 15 (2), pp.102-11. &amp;#x27E8;10.1016/j.tcb.2004.12.002&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno>
            <idno type="stamp" n="MEMBRANE-TRAFFIC-PATHOGENESIS" corresp="PASTEUR">Membrane Traffic and Pathogenesis</idno>
            <idno type="stamp" n="UMR3691" corresp="PASTEUR">UMR3691-Dynamique cellulaire physiologique et pathologique</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The highways and byways of prion protein trafficking.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincenza</forename>
                    <surname>Campana</surname>
                  </persName>
                  <idno type="halauthorid">222450-0</idno>
                  <affiliation ref="#struct-462726"/>
                  <affiliation ref="#struct-41988"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daniela</forename>
                    <surname>Sarnataro</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">758454</idno>
                  <idno type="halauthorid" notation="string">222452-758454</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6094-8384</idno>
                  <affiliation ref="#struct-41988"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chiara</forename>
                    <surname>Zurzolo</surname>
                  </persName>
                  <email type="md5">176d2d33334e3a340cc5551b5add841f</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="string">chiara-zurzolo</idno>
                  <idno type="idhal" notation="numeric">746960</idno>
                  <idno type="halauthorid" notation="string">4971-746960</idno>
                  <idno type="IDREF">https://www.idref.fr/11602075X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6048-6602</idno>
                  <affiliation ref="#struct-462726"/>
                  <affiliation ref="#struct-41988"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12463</idno>
                <idno type="issn">0962-8924</idno>
                <title level="j">Trends in Cell Biology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">15</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">102-11</biblScope>
                  <date type="datePub">2005-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.tcb.2004.12.002</idno>
              <idno type="pubmed">15695097</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Cell Membrane</classCode>
              <classCode scheme="mesh">Transport Vesicles</classCode>
              <classCode scheme="mesh">Endoplasmic Reticulum</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Membrane Microdomains</classCode>
              <classCode scheme="mesh">Models, Biological</classCode>
              <classCode scheme="mesh">PrPC Proteins</classCode>
              <classCode scheme="mesh">PrPSc Proteins</classCode>
              <classCode scheme="mesh">Prions</classCode>
              <classCode scheme="mesh">Protein Transport</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bm">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Prions are defined as infectious agents that comprise only proteins and are responsible for transmissible spongiform encephalopathies (TSEs)--fatal neurodegenerative diseases that affect humans and other mammals and include Creutzfeldt-Jacob disease in humans, scrapie in sheep and bovine spongiform encephalopathy in cattle. Prions have been proposed to arise from the conformational conversion of the cellular prion protein PrP(C) to a misfolded form termed PrP(Sc) that precipitates into aggregates and fibrils. The conversion process might be triggered by interaction of the infectious form with the cellular form or it might result from a mutation in the gene encoding PrP(C). Exactly how and where in the cell the interaction and the conversion of PrP(C) to PrP(Sc) occur, however, remain controversial. Recent studies have shed light on the intracellular trafficking of PrP(C), the role of protein mis-sorting and the cellular factors that are thought to be required for the conformational conversion of prion proteins.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-462726" status="OLD">
          <orgName>Trafic membranaire et Pathogénèse</orgName>
          <date type="start">2002-01-01</date>
          <desc>
            <address>
              <addrLine>Département de Biologie cellulaire et Infection, 25-28, rue du docteur Roux, 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://research.pasteur.fr/fr/team/membrane-traffic-and-pathogenesis/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-41988" status="VALID">
          <orgName>Dipartimento di Biologia e Patologia Cellulare e Moleculare</orgName>
          <desc>
            <address>
              <addrLine>Centro di Biotecnologie Avanzate, Università degli Studi di Napoli "Federico II," via Pansini 5, 80131 Napoli</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-544964" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-544964" status="VALID">
          <idno type="IdRef">026430622</idno>
          <idno type="ROR">https://ror.org/05290cv24</idno>
          <orgName>University of Naples Federico II = Università degli studi di Napoli Federico II</orgName>
          <orgName type="acronym">UNINA</orgName>
          <desc>
            <address>
              <addrLine>Via Cintia Monte S. Angelo, 80126 Napoli, Italy</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.unina.it</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>