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Journal Articles Journal de Physique II Year : 1994

Phase diagram of imprinted copolymers

Vijay Pande
  • Function : Author
Alexander Grosberg
  • Function : Author
Toyoichi Tanaka
  • Function : Author


Recently, a model for the preparation of “protein-like" heteropolymers with a unique and stable ground state has been proposed and examined computationally. Formally, this model is similar to another recently proposed and computationally examined model of the evolutionary design of protein-like heteropolymers. Using mean field replica theory, we find, in addition to the freezing transition of random chains, a transition to the target “native" state. The stability of this state is shown to be greater than that of the ground state of random chains. The results derived here should at least qualitatively be applicable to known biopolymers, which are conjectured to be in vivo “designed" by evolution. Furthermore, we present a crude prescription for a laboratory procedure in which chains can be synthesized in vitro.
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Dates and versions

jpa-00248077 , version 1 (01-01-1994)



Vijay Pande, Alexander Grosberg, Toyoichi Tanaka. Phase diagram of imprinted copolymers. Journal de Physique II, 1994, 4 (10), pp.1771-1784. ⟨10.1051/jp2:1994231⟩. ⟨jpa-00248077⟩


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