<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-03993844</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-21T09:07:35+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the ICU: An Observational Study From the OUTCOMEREA Database, 1997–2018</title>
            <author role="aut">
              <persName>
                <forename type="first">Louis-Marie</forename>
                <surname>Galerneau</surname>
              </persName>
              <idno type="halauthorid">2012124-0</idno>
              <affiliation ref="#struct-1079233"/>
              <affiliation ref="#struct-570573"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Bailly</surname>
              </persName>
              <idno type="halauthorid">51754-0</idno>
              <affiliation ref="#struct-1079233"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Terzi</surname>
              </persName>
              <idno type="halauthorid">490719-0</idno>
              <affiliation ref="#struct-570573"/>
              <affiliation ref="#struct-1079233"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stéphane</forename>
                <surname>Ruckly</surname>
              </persName>
              <idno type="halauthorid">851557-0</idno>
              <affiliation ref="#struct-320859"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maité</forename>
                <surname>Garrouste-Orgeas</surname>
              </persName>
              <idno type="halauthorid">360482-0</idno>
              <affiliation ref="#struct-1159905"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yves</forename>
                <surname>Cohen</surname>
              </persName>
              <idno type="halauthorid">2530341-0</idno>
              <affiliation ref="#struct-300210"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vivien</forename>
                <surname>Hong Tuan Ha</surname>
              </persName>
              <idno type="halauthorid">2336232-0</idno>
              <affiliation ref="#struct-310666"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Gainnier</surname>
              </persName>
              <idno type="halauthorid">1169048-0</idno>
              <affiliation ref="#struct-300093"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Shidasp</forename>
                <surname>Siami</surname>
              </persName>
              <idno type="halauthorid">588553-0</idno>
              <affiliation ref="#struct-184952"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Dupuis</surname>
              </persName>
              <email type="md5">ac922b819db1304c1ce957c976432c14</email>
              <email type="domain">chu-clermontferrand.fr</email>
              <idno type="idhal" notation="string">claire-dupuis</idno>
              <idno type="idhal" notation="numeric">1100666</idno>
              <idno type="halauthorid" notation="string">789209-1100666</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3533-3097</idno>
              <affiliation ref="#struct-355679"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Darmon</surname>
              </persName>
              <idno type="halauthorid">370545-0</idno>
              <affiliation ref="#struct-506757"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Marie</forename>
                <surname>Forel</surname>
              </persName>
              <email type="md5">8db0324721b7250fa3cabc4887dc0362</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">760690</idno>
              <idno type="halauthorid" notation="string">369945-760690</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1958-7388</idno>
              <affiliation ref="#struct-301315"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guillaume</forename>
                <surname>Rigault</surname>
              </persName>
              <idno type="halauthorid">1481871-0</idno>
              <affiliation ref="#struct-257328"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Adrie</surname>
              </persName>
              <idno type="halauthorid">219930-0</idno>
              <affiliation ref="#struct-91121"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Dany</forename>
                <surname>Goldgran-Toledano</surname>
              </persName>
              <idno type="halauthorid">219938-0</idno>
              <affiliation ref="#struct-409419"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Virginie</forename>
                <surname>Laurent</surname>
              </persName>
              <idno type="halauthorid">162838-0</idno>
              <affiliation ref="#struct-302301"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Etienne</forename>
                <surname>de Montmollin</surname>
              </persName>
              <idno type="halauthorid">869334-0</idno>
              <affiliation ref="#struct-1041760"/>
              <affiliation ref="#struct-1005021"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Argaud</surname>
              </persName>
              <idno type="halauthorid">395717-0</idno>
              <affiliation ref="#struct-300094"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean</forename>
                <surname>Reignier</surname>
              </persName>
              <idno type="halauthorid">370554-0</idno>
              <affiliation ref="#struct-474972"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Louis</forename>
                <surname>Pepin</surname>
              </persName>
              <idno type="halauthorid">366047-0</idno>
              <affiliation ref="#struct-1079233"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-François</forename>
                <surname>Timsit</surname>
              </persName>
              <idno type="halauthorid">228981-0</idno>
              <affiliation ref="#struct-1041760"/>
              <affiliation ref="#struct-1005021"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Danielle</forename>
                <surname>SALAS</surname>
              </persName>
              <email type="md5">c21f7387155c88c6e148ef2135a5b6da</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
            <funder ref="#projanr-50501"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-02-17 11:00:11</date>
              <date type="whenModified">2026-04-01 03:13:25</date>
              <date type="whenReleased">2023-04-06 13:56:52</date>
              <date type="whenProduced">2023</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1085580">
                <persName>
                  <forename>Danielle</forename>
                  <surname>SALAS</surname>
                </persName>
                <email type="md5">c21f7387155c88c6e148ef2135a5b6da</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-03993844</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-03993844</idno>
            <idno type="halBibtex">galerneau:inserm-03993844</idno>
            <idno type="halRefHtml">&lt;i&gt;Critical Care Medicine&lt;/i&gt;, 2023, Online ahead of print. &lt;a target="_blank" href="https://dx.doi.org/10.1097/CCM.0000000000005807"&gt;&amp;#x27E8;10.1097/CCM.0000000000005807&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Critical Care Medicine, 2023, Online ahead of print. &amp;#x27E8;10.1097/CCM.0000000000005807&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="HEH" corresp="HCL">Hôpital Edouard Herriot</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="IAME" corresp="UNIV-PARIS13">Infection, Anti-microbiens, Modélisation, Evolution - UMR 1137</idno>
            <idno type="stamp" n="CHU-CLERMONTFERRAND">CHU DE CLERMONT FERRAND</idno>
            <idno type="stamp" n="IBHGC" corresp="UNIV-PARIS13">Institut de Biomécanique Humaine Georges Charpak</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="MIAI">Multidisciplinary Institute in Artificial intelligence - Grenoble Alpes</idno>
            <idno type="stamp" n="PNRIA">Programme National de Recherche en IA</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="ACT-R" corresp="UNIV-PARIS13">Act'R </idno>
            <idno type="stamp" n="MI2">Inflammation, microbiome, immunosurveillance</idno>
            <idno type="stamp" n="UNH_ASMS">UNH – Equipe ASMS</idno>
            <idno type="stamp" n="ANR-IA-19" corresp="ANR-IA">ANR-IA-19</idno>
            <idno type="stamp" n="ANR-IA">ANR-IA</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the ICU: An Observational Study From the OUTCOMEREA Database, 1997–2018</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Louis-Marie</forename>
                    <surname>Galerneau</surname>
                  </persName>
                  <idno type="halauthorid">2012124-0</idno>
                  <affiliation ref="#struct-1079233"/>
                  <affiliation ref="#struct-570573"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Bailly</surname>
                  </persName>
                  <idno type="halauthorid">51754-0</idno>
                  <affiliation ref="#struct-1079233"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Terzi</surname>
                  </persName>
                  <idno type="halauthorid">490719-0</idno>
                  <affiliation ref="#struct-570573"/>
                  <affiliation ref="#struct-1079233"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stéphane</forename>
                    <surname>Ruckly</surname>
                  </persName>
                  <idno type="halauthorid">851557-0</idno>
                  <affiliation ref="#struct-320859"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maité</forename>
                    <surname>Garrouste-Orgeas</surname>
                  </persName>
                  <idno type="halauthorid">360482-0</idno>
                  <affiliation ref="#struct-1159905"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yves</forename>
                    <surname>Cohen</surname>
                  </persName>
                  <idno type="halauthorid">2530341-0</idno>
                  <affiliation ref="#struct-300210"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vivien</forename>
                    <surname>Hong Tuan Ha</surname>
                  </persName>
                  <idno type="halauthorid">2336232-0</idno>
                  <affiliation ref="#struct-310666"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Gainnier</surname>
                  </persName>
                  <idno type="halauthorid">1169048-0</idno>
                  <affiliation ref="#struct-300093"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Shidasp</forename>
                    <surname>Siami</surname>
                  </persName>
                  <idno type="halauthorid">588553-0</idno>
                  <affiliation ref="#struct-184952"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Dupuis</surname>
                  </persName>
                  <email type="md5">ac922b819db1304c1ce957c976432c14</email>
                  <email type="domain">chu-clermontferrand.fr</email>
                  <idno type="idhal" notation="string">claire-dupuis</idno>
                  <idno type="idhal" notation="numeric">1100666</idno>
                  <idno type="halauthorid" notation="string">789209-1100666</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3533-3097</idno>
                  <affiliation ref="#struct-355679"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Darmon</surname>
                  </persName>
                  <idno type="halauthorid">370545-0</idno>
                  <affiliation ref="#struct-506757"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Marie</forename>
                    <surname>Forel</surname>
                  </persName>
                  <email type="md5">8db0324721b7250fa3cabc4887dc0362</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">760690</idno>
                  <idno type="halauthorid" notation="string">369945-760690</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1958-7388</idno>
                  <affiliation ref="#struct-301315"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guillaume</forename>
                    <surname>Rigault</surname>
                  </persName>
                  <idno type="halauthorid">1481871-0</idno>
                  <affiliation ref="#struct-257328"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Adrie</surname>
                  </persName>
                  <idno type="halauthorid">219930-0</idno>
                  <affiliation ref="#struct-91121"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Dany</forename>
                    <surname>Goldgran-Toledano</surname>
                  </persName>
                  <idno type="halauthorid">219938-0</idno>
                  <affiliation ref="#struct-409419"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Virginie</forename>
                    <surname>Laurent</surname>
                  </persName>
                  <idno type="halauthorid">162838-0</idno>
                  <affiliation ref="#struct-302301"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Etienne</forename>
                    <surname>de Montmollin</surname>
                  </persName>
                  <idno type="halauthorid">869334-0</idno>
                  <affiliation ref="#struct-1041760"/>
                  <affiliation ref="#struct-1005021"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Argaud</surname>
                  </persName>
                  <idno type="halauthorid">395717-0</idno>
                  <affiliation ref="#struct-300094"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean</forename>
                    <surname>Reignier</surname>
                  </persName>
                  <idno type="halauthorid">370554-0</idno>
                  <affiliation ref="#struct-474972"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Louis</forename>
                    <surname>Pepin</surname>
                  </persName>
                  <idno type="halauthorid">366047-0</idno>
                  <affiliation ref="#struct-1079233"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-François</forename>
                    <surname>Timsit</surname>
                  </persName>
                  <idno type="halauthorid">228981-0</idno>
                  <affiliation ref="#struct-1041760"/>
                  <affiliation ref="#struct-1005021"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12171</idno>
                <idno type="issn">0090-3493</idno>
                <idno type="eissn">1530-0293</idno>
                <title level="j">Critical Care Medicine</title>
                <imprint>
                  <publisher>Lippincott, Williams &amp; Wilkins</publisher>
                  <biblScope unit="pp">Online ahead of print</biblScope>
                  <date type="datePub">2023</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1097/CCM.0000000000005807</idno>
              <idno type="pubmed">36790209</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Objectives: Our aim was to describe changes in the management of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) by ICUs and patient outcomes.Design: We extracted data from the OutcomeRea database concerning patients admitted for AECOPD between 1997 and 2018. We analyzed trends in the use of ventilatory support, corticosteroid therapy, antibiotic therapy, and patient survival.Setting: ICUs at 32 French sites.Patients: One thousand eight hundred sixteen patients in the database had a diagnosis of AECOPD.Interventions: None.Measurements and main results: Over time, there was a reduction in the prescription of corticosteroids and antibiotics. In a time-series analysis, these changes in practice were not linked with ICU mortality. The proportion of patients treated with invasive mechanical ventilation (IMV) also gradually declined (from 51% between 1997 and 2002 to 35% between 2013 and 2018) with an association between decrease in IMV use and reduction in ICU mortality in a time series analysis. Rates of noninvasive ventilation (NIV) failure decreased with an increase in NIV use to support weaning from IMV. There was a reduction in the median ICU length of stay (from 8 d in 1997-2002 to 4 d in 2013-2018) and in the median total duration of hospitalization (from 23 d in 1997-2002 to 14 d in 2013-2018). We observed an improvement in prognosis, with decreases in overall hospital mortality (from 24% between 1997 and 2002 to 15% between 2013 and 2018), ICU mortality (from 14% between 1997 and 2002 to 10% between 2013 and 2018), and 90-day mortality (from 41% between 1997 and 2002 to 22% between 2013 and 2018).Conclusions: The length of stay and mortality of patients with AECOPD admitted to ICUs has decreased over the last 20 years, with a wider use of NIV and a reduction in antibiotic and corticosteroid prescriptions.</p>
            </abstract>
            <particDesc>
              <org type="consortium">OUTCOMEREA Network: Jean-François Timsit, Elie Azoulay, Maïté Garrouste-Orgeas, Jean-Ralph Zahar, Bruno Mourvillier, Michael Darmon, Corinne Alberti, Stephane Ruckly, Sébastien Bailly, Aurélien Vannieuwenhuyze, Christophe Adrie, Carole Agasse, Bernard Allaouchiche, Olivier Andremont, Pascal Andreu, Laurent Argaud, Claire Ara-Somohano, Elie Azoulay, Francois Barbier, Jean-Pierre Bedos, Thomas Baudry, Jérome Bedel, Julien Bohé, Lila Bouadma, Jeremy Bourenne, Noel Brule, Frank Chemouni, Julien Carvelli, Elisabeth Coupez, Michael Darmon, Claire Dupuis, Etienne de Montmollin, Loa Dopeux, Anne-Sylvie Dumenil, Claire Dupuis, Jean-Marc Forel, Marc Gainnier, Charlotte Garret, Dany Goldgran-Tonedano, Steven Grangé, Antoine Gros, Hédia Hammed, Akim Haouache, Tarik Hissem, Vivien Hong Tuan Ha, Sébastien Jochmans, Jean-Baptiste Joffredo, Hatem Kallel, Guillaume Lacave, Virgine Laurent, Alexandre Lautrette, Clément Le Bihan, Virgine Lemiale, David Luis, Guillaume Marcotte, Jordane Lebut, Bruno Mourvillier, Benoît Misset, Bruno Mourvillier, Mathild Neuville, Laurent Nicolet, Johanna Oziel, Laurent Papazian, Juliette Patrier, Benjamin Planquette, Aguila Radjou, Marie Simon, Romain Sonneville, Jean Reignier, Bertrand Souweine, Carole Schwebel, Shidasp Siami, Sonneville Romain, Nicolas Terzi, Gilles Troché, Fabrice Thiollieres, Guillaume Thierry, Guillaume Van Der Meersch, Marion Venot, Florent Wallet, Sondes Yaacoubi, Olivier Zambon, Jonathan Zarka, Mireille Adda, Vanessa Vindrieux, Marion Provent, Sylvie de la Salle, Pauline Enguerrand, Vincent Gobert, Stéphane Guessens, Helene Merle, Nadira Kaddour, Boris Berthe, Samir Bekkhouche, Kaouttar Mellouk, Mélaine Lebrazic, Carole Ouisse, Diane Maugars, Christelle Aparicio, Igor Theodose, Manal Nouacer, Veronique Deiler, Fariza Lamara, Myriam Moussa, Atika Mouaci, Nassima Viguier.</org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1079233" status="VALID">
          <idno type="IdRef">18493902X</idno>
          <idno type="RNSR">201119418N</idno>
          <orgName>Hypoxie et PhysioPathologie</orgName>
          <orgName type="acronym">HP2</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Facultés de médecine et de pharmacie Domaine de la merci 38706 LA TRONCHE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hp2.univ-grenoble-alpes.fr/accueil</ref>
          </desc>
          <listRelation>
            <relation name="U1042" active="#struct-303623" type="direct"/>
            <relation name="EA3745 / ERI17" active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-570573" status="INCOMING">
          <orgName>Unité de soins intensifs médicaux [CHU Grenoble]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-257328" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-320859" status="VALID">
          <orgName>Outcome Réa</orgName>
          <orgName type="acronym">Outcomerea</orgName>
          <date type="start">2001-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://outcomerea.fr/index.php</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1159905" status="VALID">
          <orgName>Hôpital Franco-Britannique</orgName>
          <orgName type="acronym">HFB</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.hopitalfrancobritannique.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300210" status="VALID">
          <idno type="IdRef">030351189</idno>
          <idno type="ROR">https://ror.org/03n6vs369</idno>
          <orgName>Hôpital Avicenne [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chu93.aphp.fr/hopital-avicenne-bobigny/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-310666" status="VALID">
          <idno type="IdRef">06708933X</idno>
          <orgName>Centre Hospitalier de Meaux [Meaux-sur-Marne]</orgName>
          <desc>
            <address>
              <addrLine>Grand Hôpital de l'Est Francilien, 6-8 Rue Saint-Fiacre, 77100 Meaux</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ghef.fr/presentation/nos-sites-hospitaliers/site-de-meaux</ref>
          </desc>
          <listRelation>
            <relation active="#struct-559503" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300093" status="VALID">
          <idno type="ISNI">0000 0001 0404 1115 </idno>
          <idno type="ROR">https://ror.org/05jrr4320</idno>
          <orgName>Hôpital de la Timone [CHU - APHM]</orgName>
          <orgName type="acronym">TIMONE</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-184952" status="VALID">
          <idno type="ROR">https://ror.org/0246mbd04</idno>
          <orgName>Centre Hospitalier Sud Francilien - Centre Hospitalier d'Evry</orgName>
          <orgName type="acronym">CHSF</orgName>
          <desc>
            <address>
              <addrLine>40 Avenue Serge Dassault - 91100 Corbeil-Essonnes</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-355679" status="VALID">
          <orgName>CHU Gabriel Montpied [Clermont-Ferrand]</orgName>
          <desc>
            <address>
              <addrLine>58 Rue Montalembert, 63000 Clermont-Ferrand</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-clermontferrand.fr/les-sites/site-gabriel-montpied</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300144" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-506757" status="VALID">
          <idno type="IdRef">02869614X</idno>
          <idno type="ROR">https://ror.org/049am9t04</idno>
          <orgName>Hopital Saint-Louis [AP-HP]</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <addrLine>1 Avenue Claude Vellefaux, 75010 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopital-saintlouis.aphp.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301315" status="VALID">
          <idno type="ISNI">0000 0001 0304 0719 </idno>
          <idno type="ROR">https://ror.org/029a4pp87</idno>
          <orgName>Hôpital Nord [CHU - APHM]</orgName>
          <date type="start">1964</date>
          <desc>
            <address>
              <addrLine>Hôpital Nord - Chemin des Bourrely13915Marseille cedex 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-nord</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-91121" status="VALID">
          <orgName>Hôpital Delafontaine</orgName>
          <desc>
            <address>
              <addrLine>2 rue du docteur Delafontaine 93 205 Saint-Denis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ch-stdenis.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-322589" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-409419" status="VALID">
          <orgName>Groupe Hospitalier Intercommunal Le Raincy-Montfermeil</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>10 Rue du Général Leclerc, 93370 Montfermeil</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302301" status="VALID">
          <orgName>Centre Hospitalier de Versailles André Mignot</orgName>
          <orgName type="acronym">CHV</orgName>
          <desc>
            <address>
              <addrLine>Versailles, Trappes, Andrésy et Bois d'Arcy, Chesnay</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-versailles.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1041760" status="VALID">
          <orgName>Inflammation, microbiome, immunosurveillance</orgName>
          <orgName type="acronym">MI2</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>5 rue Jean-Baptiste Clément, 92290, Châtenay-Malabry</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR 996" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1005021" status="VALID">
          <idno type="IdRef">235514829</idno>
          <idno type="RNSR">201420743R</idno>
          <orgName>Infection, Anti-microbiens, Modélisation, Evolution</orgName>
          <orgName type="acronym">IAME (UMR_S_1137 / U1137)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.iame-research.center/</ref>
          </desc>
          <listRelation>
            <relation name="U1137" active="#struct-303623" type="direct"/>
            <relation name="UMR_S_1137" active="#struct-557826" type="direct"/>
            <relation active="#struct-581146" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300094" status="VALID">
          <idno type="ROR">https://ror.org/02qt1p572</idno>
          <orgName>Hôpital Edouard Herriot [CHU - HCL]</orgName>
          <desc>
            <address>
              <addrLine>5 Place d'Arsonval69003 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hopital-edouard-herriot</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-559503" status="VALID">
          <orgName>Grand Hôpital de l'Est Francilien</orgName>
          <orgName type="acronym">GHEF</orgName>
          <desc>
            <address>
              <addrLine>Siège SocialSiège social6-8 Rue Saint-Fiacre,BP 218, 77104 Meaux cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ghef.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300144" status="VALID">
          <idno type="IdRef">026606836</idno>
          <idno type="ISNI">0000000406394151</idno>
          <idno type="ROR">https://ror.org/02tcf7a68</idno>
          <orgName>CHU Clermont-Ferrand</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-clermontferrand.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-322589" status="VALID">
          <idno type="ROR">https://ror.org/05ed8xr15</idno>
          <orgName>Centre Hospitalier de Saint-Denis [Ile-de-France]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue du Dr Delafontaine, 93200 Saint-Denis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ch-stdenis.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-581146" status="VALID">
          <idno type="IdRef">02640463X</idno>
          <idno type="ISNI">0000000121496883</idno>
          <idno type="ROR">https://ror.org/0199hds37</idno>
          <orgName>Université Sorbonne Paris Nord</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>99, avenue Jean-Baptiste Clément, 93430 Villetaneuse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-paris13.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50501" status="VALID">
          <idno type="anr">ANR-19-P3IA-0003</idno>
          <orgName>MIAI</orgName>
          <desc>MIAI @ Grenoble Alpes</desc>
          <date type="start">2019</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>