<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-03736401</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-26T12:30:47+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Enhanced level of VCAM in transplant preservation fluid is an independent predictor of Early Kidney Allograft Dysfunction</title>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Baboudjian</surname>
              </persName>
              <idno type="halauthorid">2151655-0</idno>
              <affiliation ref="#struct-417872"/>
              <affiliation ref="#struct-1002339"/>
              <affiliation ref="#struct-301315"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bastien</forename>
                <surname>Gondran Tellier</surname>
              </persName>
              <idno type="halauthorid">2164132-0</idno>
              <affiliation ref="#struct-417872"/>
              <affiliation ref="#struct-1002339"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Romain</forename>
                <surname>Boissier</surname>
              </persName>
              <idno type="halauthorid">1116350-0</idno>
              <affiliation ref="#struct-417872"/>
              <affiliation ref="#struct-1002339"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patricia</forename>
                <surname>Ancel</surname>
              </persName>
              <idno type="halauthorid">1092259-0</idno>
              <affiliation ref="#struct-1002339"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Juline</forename>
                <surname>Marjollet</surname>
              </persName>
              <idno type="halauthorid">2568306-0</idno>
              <affiliation ref="#struct-1002339"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luc</forename>
                <surname>Lyonnet</surname>
              </persName>
              <email type="md5">ff35e86e9af1e14faae187d2ef9f2ec5</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">1126375</idno>
              <idno type="halauthorid" notation="string">613621-1126375</idno>
              <affiliation ref="#struct-417872"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pauline</forename>
                <surname>François</surname>
              </persName>
              <idno type="halauthorid">1675482-0</idno>
              <affiliation ref="#struct-1002339"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Sabatier</surname>
              </persName>
              <email type="md5">b7ee8d5c4f2948428b60f5ae29a24d40</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">958995</idno>
              <idno type="halauthorid" notation="string">216465-958995</idno>
              <affiliation ref="#struct-1002339"/>
              <affiliation ref="#struct-417873"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Lechevallier</surname>
              </persName>
              <email type="md5">78b58295b9b532c7a5728db7f1e97d37</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">1134573</idno>
              <idno type="halauthorid" notation="string">346573-1134573</idno>
              <affiliation ref="#struct-417872"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Dutour-Meyer</surname>
              </persName>
              <idno type="halauthorid">727479-0</idno>
              <affiliation ref="#struct-1002339"/>
              <affiliation ref="#struct-300073"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Pascale</forename>
                <surname>Paul</surname>
              </persName>
              <email type="md5">36dddfd11b592e1d5dac00f5a5f57590</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">pascale-paul13</idno>
              <idno type="idhal" notation="numeric">751165</idno>
              <idno type="halauthorid" notation="string">132139-751165</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/R-1484-2016</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6734-4479</idno>
              <affiliation ref="#struct-1002339"/>
              <affiliation ref="#struct-417872"/>
              <affiliation ref="#struct-526050"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pascale</forename>
                <surname>Paul</surname>
              </persName>
              <email type="md5">36dddfd11b592e1d5dac00f5a5f57590</email>
              <email type="domain">inserm.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-07-22 12:52:07</date>
              <date type="whenModified">2026-04-22 09:36:22</date>
              <date type="whenReleased">2022-08-16 14:39:56</date>
              <date type="whenProduced">2022-08-11</date>
              <date type="whenEndEmbargoed">2022-08-16</date>
              <ref type="file" target="https://inserm.hal.science/inserm-03736401v1/document">
                <date notBefore="2022-08-16"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://inserm.hal.science/inserm-03736401v1/file/fimmu-13-966951.pdf" id="file-3736401-3279352">
                <date notBefore="2022-08-16"/>
              </ref>
              <fs>
                <f name="inra_etatDocument_local" notation="numeric">
                  <numeric>0</numeric>
                </f>
                <f name="inra_etatDocument_local" notation="string" n="0">
                  <string>inra_etatDocument_local_0</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1112959">
                <persName>
                  <forename>Pascale</forename>
                  <surname>Paul</surname>
                </persName>
                <email type="md5">36dddfd11b592e1d5dac00f5a5f57590</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-03736401</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-03736401</idno>
            <idno type="halBibtex">baboudjian:inserm-03736401</idno>
            <idno type="halRefHtml">&lt;i&gt;Frontiers in Immunology&lt;/i&gt;, 2022, 13, pp.966951. &lt;a target="_blank" href="https://dx.doi.org/10.3389/fimmu.2022.966951"&gt;&amp;#x27E8;10.3389/fimmu.2022.966951&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Frontiers in Immunology, 2022, 13, pp.966951. &amp;#x27E8;10.3389/fimmu.2022.966951&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3736401-3279352"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="TAGC">Technologies avancées pour le génôme et la clinique</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="INRAEPACA">INRAE PACA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Enhanced level of VCAM in transplant preservation fluid is an independent predictor of Early Kidney Allograft Dysfunction</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Baboudjian</surname>
                  </persName>
                  <idno type="halauthorid">2151655-0</idno>
                  <affiliation ref="#struct-417872"/>
                  <affiliation ref="#struct-1002339"/>
                  <affiliation ref="#struct-301315"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bastien</forename>
                    <surname>Gondran Tellier</surname>
                  </persName>
                  <idno type="halauthorid">2164132-0</idno>
                  <affiliation ref="#struct-417872"/>
                  <affiliation ref="#struct-1002339"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Romain</forename>
                    <surname>Boissier</surname>
                  </persName>
                  <idno type="halauthorid">1116350-0</idno>
                  <affiliation ref="#struct-417872"/>
                  <affiliation ref="#struct-1002339"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patricia</forename>
                    <surname>Ancel</surname>
                  </persName>
                  <idno type="halauthorid">1092259-0</idno>
                  <affiliation ref="#struct-1002339"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Juline</forename>
                    <surname>Marjollet</surname>
                  </persName>
                  <idno type="halauthorid">2568306-0</idno>
                  <affiliation ref="#struct-1002339"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luc</forename>
                    <surname>Lyonnet</surname>
                  </persName>
                  <email type="md5">ff35e86e9af1e14faae187d2ef9f2ec5</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">1126375</idno>
                  <idno type="halauthorid" notation="string">613621-1126375</idno>
                  <affiliation ref="#struct-417872"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pauline</forename>
                    <surname>François</surname>
                  </persName>
                  <idno type="halauthorid">1675482-0</idno>
                  <affiliation ref="#struct-1002339"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Sabatier</surname>
                  </persName>
                  <email type="md5">b7ee8d5c4f2948428b60f5ae29a24d40</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">958995</idno>
                  <idno type="halauthorid" notation="string">216465-958995</idno>
                  <affiliation ref="#struct-1002339"/>
                  <affiliation ref="#struct-417873"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Lechevallier</surname>
                  </persName>
                  <email type="md5">78b58295b9b532c7a5728db7f1e97d37</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">1134573</idno>
                  <idno type="halauthorid" notation="string">346573-1134573</idno>
                  <affiliation ref="#struct-417872"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Dutour-Meyer</surname>
                  </persName>
                  <idno type="halauthorid">727479-0</idno>
                  <affiliation ref="#struct-1002339"/>
                  <affiliation ref="#struct-300073"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Pascale</forename>
                    <surname>Paul</surname>
                  </persName>
                  <email type="md5">36dddfd11b592e1d5dac00f5a5f57590</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">pascale-paul13</idno>
                  <idno type="idhal" notation="numeric">751165</idno>
                  <idno type="halauthorid" notation="string">132139-751165</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/R-1484-2016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6734-4479</idno>
                  <affiliation ref="#struct-1002339"/>
                  <affiliation ref="#struct-417872"/>
                  <affiliation ref="#struct-526050"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">73691</idno>
                <idno type="issn">1664-3224</idno>
                <idno type="eissn">1664-3224</idno>
                <title level="j">Frontiers in Immunology</title>
                <imprint>
                  <publisher>Frontiers</publisher>
                  <biblScope unit="volume">13</biblScope>
                  <biblScope unit="pp">966951</biblScope>
                  <date type="datePub">2022-08-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3389/fimmu.2022.966951</idno>
              <idno type="pubmed">36032101</idno>
              <idno type="wos">000844355900001</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">VCAM</term>
                <term xml:lang="en">kidney transplantation</term>
                <term xml:lang="en">extended criteria donor</term>
                <term xml:lang="en">delayed graft function</term>
                <term xml:lang="en">machine perfusion</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: We aimed to evaluate whether donor-related inflammatory markers found in kidney transplant preservation fluid can associate with early development of kidney allograft dysfunction.Methods: Our prospective study enrolled 74 consecutive donated organs who underwent kidney transplantation in our center between September 2020 and June 2021. Kidneys from 27 standard criteria donors were allocated to static cold storage and kidneys from 47 extended criteria donors to hypothermic machine perfusion. ELISA assessment of inflammatory biomarkers (IL-6, IL6-R, ICAM, VCAM, TNFα, IFN-g, CXCL1 and Fractalkine) was analyzed in view of a primary endpoint defined as the occurrence of delayed graft function or slow graft function during the first week following transplantation.Results: Soluble VCAM levels measured in transplant conservation fluid were significantly associated with recipient serum creatinine on day 7. Multivariate stepwise logistic regression analysis identified VCAM as an independent non-invasive predictor of early graft dysfunction, both at 1 week (OR: 3.57, p = .04, 95% CI: 1.06-12.03) and 3 Months (OR: 4.039, p = .034, 95% CI: 1.11-14.73) after transplant surgery.Conclusions: This prospective pilot study suggests that pre-transplant evaluation of VCAM levels could constitute a valuable indicator of transplant health and identify the VCAM-CD49d pathway as a target to limit donor-related vascular injury of marginal transplants.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-417872" status="VALID">
          <idno type="ISNI">0000 0004 0638 9491 </idno>
          <idno type="ROR">https://ror.org/00s7v8q53</idno>
          <orgName>Hôpital de la Conception [CHU - APHM]</orgName>
          <orgName type="acronym">LA CONCEPTION</orgName>
          <date type="start">1985-01-01</date>
          <desc>
            <address>
              <addrLine>147 Boulevard Baille 13005 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-conception</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1002339" status="VALID">
          <idno type="RNSR">201822670T</idno>
          <orgName>Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research</orgName>
          <orgName type="acronym">C2VN</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine de la Timone 27 boulevard Jean Moulin 13385 MARSEILLE CEDEX 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://c2vn.univ-amu.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_S1263" active="#struct-198056" type="direct"/>
            <relation name="UMR_S1263" active="#struct-303623" type="direct"/>
            <relation name="UMR1260" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301315" status="VALID">
          <idno type="ISNI">0000 0001 0304 0719 </idno>
          <idno type="ROR">https://ror.org/029a4pp87</idno>
          <orgName>Hôpital Nord [CHU - APHM]</orgName>
          <date type="start">1964</date>
          <desc>
            <address>
              <addrLine>Hôpital Nord - Chemin des Bourrely13915Marseille cedex 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-nord</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-417873" status="VALID">
          <orgName>Centre d'Investigation Clinique [Hôpital de la Conception - APHM]</orgName>
          <orgName type="acronym">CIC</orgName>
          <date type="start">1955</date>
          <desc>
            <address>
              <addrLine>CIC9502 - Hôpital de la ConceptionService Néphrologie - 3ème étage147, boulevard Baille13385 Marseille cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/site/centre-investigation-clinique-marseille/presentation</ref>
          </desc>
          <listRelation>
            <relation active="#struct-198056" type="direct"/>
            <relation active="#struct-300073" type="direct"/>
            <relation active="#struct-301325" type="direct"/>
            <relation active="#struct-301051" type="indirect"/>
            <relation name="CIC1409" active="#struct-303623" type="direct"/>
            <relation active="#struct-417872" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
          <desc>
            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-526050" status="VALID">
          <idno type="RNSR">201220169A</idno>
          <orgName>Theories and Approaches of Genomic Complexity</orgName>
          <orgName type="acronym">TAGC</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>Parc scientifique de Luminy - 163 avenue de Luminy 13288 Marseille cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://tagc.univ-amu.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-198056" type="direct"/>
            <relation name="U1090" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301325" status="VALID">
          <idno type="ROR">https://ror.org/04s3t1g37</idno>
          <orgName>Institut Paoli-Calmettes</orgName>
          <orgName type="acronym">IPC</orgName>
          <desc>
            <address>
              <addrLine>232 Boulevard de Sainte-Marguerite13009 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institutpaolicalmettes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301051" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301051" status="VALID">
          <orgName>Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>