<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-03455713</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T16:21:46+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage</title>
            <author role="aut">
              <persName>
                <forename type="first">S</forename>
                <surname>de Groef</surname>
              </persName>
              <idno type="halauthorid">2355558-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D</forename>
                <surname>Renmans</surname>
              </persName>
              <idno type="halauthorid">2355559-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Y</forename>
                <surname>Cai</surname>
              </persName>
              <idno type="halauthorid">1997564-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">G</forename>
                <surname>Leuckx</surname>
              </persName>
              <idno type="halauthorid">2355560-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S</forename>
                <surname>Roels</surname>
              </persName>
              <idno type="halauthorid">1907796-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">W</forename>
                <surname>Staels</surname>
              </persName>
              <idno type="halauthorid">2355561-0</idno>
              <affiliation ref="#struct-303465"/>
              <affiliation ref="#struct-334659"/>
              <affiliation ref="#struct-302729"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">G</forename>
                <surname>Gradwohl</surname>
              </persName>
              <email type="md5">dd86055560856ea1ec21475e40feeae5</email>
              <email type="domain">igbmc.fr</email>
              <idno type="idhal" notation="string">gerard-gradwohl</idno>
              <idno type="idhal" notation="numeric">181394</idno>
              <idno type="halauthorid" notation="string">1718927-181394</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6730-2615</idno>
              <idno type="IDREF">https://www.idref.fr/101547390</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/1145323</idno>
              <affiliation ref="#struct-93800"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L</forename>
                <surname>Baeyens</surname>
              </persName>
              <idno type="halauthorid">2355562-0</idno>
              <affiliation ref="#struct-303465"/>
              <affiliation ref="#struct-190541"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Y</forename>
                <surname>Heremans</surname>
              </persName>
              <idno type="halauthorid">962689-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">G</forename>
                <surname>Martens</surname>
              </persName>
              <idno type="halauthorid">2355563-0</idno>
              <affiliation ref="#struct-303465"/>
              <affiliation ref="#struct-553799"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">N</forename>
                <surname>de Leu</surname>
              </persName>
              <idno type="halauthorid">962690-0</idno>
              <affiliation ref="#struct-303465"/>
              <affiliation ref="#struct-335916"/>
              <affiliation ref="#struct-1082048"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M</forename>
                <surname>Sojoodi</surname>
              </persName>
              <idno type="halauthorid">1732373-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M</forename>
                <surname>van de Casteele</surname>
              </persName>
              <idno type="halauthorid">2355564-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">H</forename>
                <surname>Heimberg</surname>
              </persName>
              <idno type="halauthorid">962691-0</idno>
              <affiliation ref="#struct-303465"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Gérard</forename>
                <surname>Gradwohl</surname>
              </persName>
              <email type="md5">dd86055560856ea1ec21475e40feeae5</email>
              <email type="domain">igbmc.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-11-29 18:29:28</date>
              <date type="whenModified">2026-01-22 12:20:05</date>
              <date type="whenReleased">2021-11-30 11:04:59</date>
              <date type="whenProduced">2016-06</date>
              <date type="whenEndEmbargoed">2021-11-30</date>
              <ref type="file" target="https://inserm.hal.science/inserm-03455713v1/document">
                <date notBefore="2021-11-30"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://inserm.hal.science/inserm-03455713v1/file/cddis2016171.pdf" id="file-3455713-3030992">
                <date notBefore="2021-11-30"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143397"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="12047">
                <persName>
                  <forename>Gérard</forename>
                  <surname>Gradwohl</surname>
                </persName>
                <email type="md5">dd86055560856ea1ec21475e40feeae5</email>
                <email type="domain">igbmc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-03455713</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-03455713</idno>
            <idno type="halBibtex">degroef:inserm-03455713</idno>
            <idno type="halRefHtml">&lt;i&gt;Cell Death and Disease&lt;/i&gt;, 2016, 7 (6), pp.e2272-e2272. &lt;a target="_blank" href="https://dx.doi.org/10.1038/cddis.2016.171"&gt;&amp;#x27E8;10.1038/cddis.2016.171&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cell Death and Disease, 2016, 7 (6), pp.e2272-e2272. &amp;#x27E8;10.1038/cddis.2016.171&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3455713-3030992"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGBMC" corresp="INSERM">Institut Génétique de Biologie Moléculaire et Cellulaire</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage</title>
                <author role="aut">
                  <persName>
                    <forename type="first">S</forename>
                    <surname>de Groef</surname>
                  </persName>
                  <idno type="halauthorid">2355558-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D</forename>
                    <surname>Renmans</surname>
                  </persName>
                  <idno type="halauthorid">2355559-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Y</forename>
                    <surname>Cai</surname>
                  </persName>
                  <idno type="halauthorid">1997564-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">G</forename>
                    <surname>Leuckx</surname>
                  </persName>
                  <idno type="halauthorid">2355560-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S</forename>
                    <surname>Roels</surname>
                  </persName>
                  <idno type="halauthorid">1907796-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">W</forename>
                    <surname>Staels</surname>
                  </persName>
                  <idno type="halauthorid">2355561-0</idno>
                  <affiliation ref="#struct-303465"/>
                  <affiliation ref="#struct-334659"/>
                  <affiliation ref="#struct-302729"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">G</forename>
                    <surname>Gradwohl</surname>
                  </persName>
                  <email type="md5">dd86055560856ea1ec21475e40feeae5</email>
                  <email type="domain">igbmc.fr</email>
                  <idno type="idhal" notation="string">gerard-gradwohl</idno>
                  <idno type="idhal" notation="numeric">181394</idno>
                  <idno type="halauthorid" notation="string">1718927-181394</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6730-2615</idno>
                  <idno type="IDREF">https://www.idref.fr/101547390</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/1145323</idno>
                  <affiliation ref="#struct-93800"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L</forename>
                    <surname>Baeyens</surname>
                  </persName>
                  <idno type="halauthorid">2355562-0</idno>
                  <affiliation ref="#struct-303465"/>
                  <affiliation ref="#struct-190541"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Y</forename>
                    <surname>Heremans</surname>
                  </persName>
                  <idno type="halauthorid">962689-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">G</forename>
                    <surname>Martens</surname>
                  </persName>
                  <idno type="halauthorid">2355563-0</idno>
                  <affiliation ref="#struct-303465"/>
                  <affiliation ref="#struct-553799"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">N</forename>
                    <surname>de Leu</surname>
                  </persName>
                  <idno type="halauthorid">962690-0</idno>
                  <affiliation ref="#struct-303465"/>
                  <affiliation ref="#struct-335916"/>
                  <affiliation ref="#struct-1082048"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M</forename>
                    <surname>Sojoodi</surname>
                  </persName>
                  <idno type="halauthorid">1732373-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M</forename>
                    <surname>van de Casteele</surname>
                  </persName>
                  <idno type="halauthorid">2355564-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">H</forename>
                    <surname>Heimberg</surname>
                  </persName>
                  <idno type="halauthorid">962691-0</idno>
                  <affiliation ref="#struct-303465"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">108671</idno>
                <idno type="issn">2041-4889</idno>
                <title level="j">Cell Death and Disease</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">7</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">e2272-e2272</biblScope>
                  <date type="datePub">2016-06</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/cddis.2016.171</idno>
              <idno type="pubmed">27336716</idno>
              <idno type="pubmedcentral">PMC5143397</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the β-cell mass mainly through proliferation of pre-existing and newly formed β-cells. The molecular mechanism governing this process is still largely unknown. Given the inflammatory nature of PDL and inflammation-induced signaling via the signal transducer and activator of transcription 3 (STAT3), the activation and the role of STAT3 in PDL-induced β-cell proliferation were investigated. Duct ligation stimulates the expression of several cytokines that can act as ligands inducing STAT3 signaling and phosphorylation in β-cells. β-Cell cycling increased by conditional β-cell-specific Stat3 knockout and decreased by STAT3 activation through administration of interleukin-6. In addition, the level of DNA damage in β-cells of PDL pancreas increased after deletion of Stat3. These data indicate a role for STAT3 in maintaining a steady state in the β-cell, by modulating its cell cycle and protection from DNA damage.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regroupinstitution" xml:id="struct-303465" status="VALID">
          <idno type="IdRef">026432838</idno>
          <idno type="ISNI">0000 0001 2290 8069</idno>
          <idno type="ROR">https://ror.org/006e5kg04</idno>
          <idno type="Wikidata">Q612665</idno>
          <orgName>Vrije Universiteit Brussel [Bruxelles]</orgName>
          <orgName type="acronym">VUB</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>Pleinlaan 2, 1050 Brussel</addrLine>
              <country key="BE"/>
            </address>
            <ref type="url">https://www.vub.be/en/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-334659" status="VALID">
          <orgName>Ghent University Hospital</orgName>
          <desc>
            <address>
              <addrLine>De Pintelaan 185, 9000 Gent, Belgium</addrLine>
              <country key="BE"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-302729" status="VALID">
          <idno type="ROR">https://ror.org/00cv9y106</idno>
          <orgName>Universiteit Gent = Ghent University = Université de Gand</orgName>
          <orgName type="acronym">UGent</orgName>
          <date type="start">1817-01-01</date>
          <desc>
            <address>
              <addrLine>St. Pietersnieuwstraat 33, 9000 Gent</addrLine>
              <country key="BE"/>
            </address>
            <ref type="url">https://www.ugent.be/en</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-93800" status="VALID">
          <idno type="IdRef">155263749</idno>
          <idno type="ISNI">0000 0004 0638 2716</idno>
          <idno type="RNSR">200112491C</idno>
          <idno type="ROR">https://ror.org/0015ws592</idno>
          <idno type="Wikidata">Q3152004</idno>
          <orgName>Institut de Génétique et de Biologie Moléculaire et Cellulaire</orgName>
          <orgName type="acronym">IGBMC</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igbmc.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS964" active="#struct-199013" type="direct"/>
            <relation name="U1258" active="#struct-303623" type="direct"/>
            <relation name="UMR7104" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-190541" status="VALID">
          <idno type="ROR">https://ror.org/043mz5j54</idno>
          <orgName>University of California [San Francisco]</orgName>
          <orgName type="acronym">UC San Francisco</orgName>
          <desc>
            <address>
              <addrLine>505 Parnassus Ave, San Francisco, CA 94143</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.ucsf.edu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-471291" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-553799" status="INCOMING">
          <orgName>Universitair Ziekenhuis [Brussels, Belgium]</orgName>
          <desc>
            <address>
              <country key="BE"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-335916" status="VALID">
          <orgName>Universitair Ziekenhuis Brussel = University Hospital of Brussels</orgName>
          <orgName type="acronym">UZ Brussel</orgName>
          <desc>
            <address>
              <addrLine>Universitair Ziekenhuis BrusselBrussels Health CampusLaarbeeklaan 1011090 Jette</addrLine>
              <country key="BE"/>
            </address>
            <ref type="url">https://www.uzbrussel.be/web/international</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1082048" status="INCOMING">
          <orgName>Algemeen Stedelijk Ziekenhuis Aalst [Aalst, Belgium]</orgName>
          <orgName type="acronym">ASZ</orgName>
          <desc>
            <address>
              <country key="BE"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-471291" status="VALID">
          <idno type="ROR">https://ror.org/00pjdza24</idno>
          <orgName>University of California</orgName>
          <orgName type="acronym">UC</orgName>
          <date type="start">1869-01-01</date>
          <desc>
            <address>
              <country key="US"/>
            </address>
            <ref type="url">https://www.universityofcalifornia.edu/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>