Delta-Opioid Receptors Mediate Unique Plasticity onto Parvalbumin-Expressing Interneurons in Area CA2 of the Hippocampus - Archive ouverte HAL Access content directly
Journal Articles Journal of Neuroscience Year : 2013

Delta-Opioid Receptors Mediate Unique Plasticity onto Parvalbumin-Expressing Interneurons in Area CA2 of the Hippocampus

Abstract

Inhibition is critical for controlling information transfer in the brain. However, the understanding of the plasticity and particular function of different interneuron subtypes is just emerging. Using acute hippocampal slices prepared from adult mice, we report that in area CA2 of the hippocampus, a powerful inhibitory transmission is acting as a gate to prevent CA3 inputs from driving CA2 neurons. Furthermore, this inhibition is highly plastic, and undergoes a long-term depression following high-frequency 10 Hz or theta-burst induction protocols. We describe a novel form of long-term depression at parvalbumin-expressing (PV+) interneuron synapses that is dependent on delta-opioid receptor (DOR) activation. Additionally, PV+ interneuron transmission is persistently depressed by DOR activation in area CA2 but only transiently depressed in area CA1. These results provide evidence for a differential temporal modulation of PV+ synapses between two adjacent cortical circuits, and highlight a new function of PV+ cells in controlling information transfer.

Domains

Neurobiology

Dates and versions

inserm-02769098 , version 1 (04-06-2020)

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R. Piskorowski, V. Chevaleyre. Delta-Opioid Receptors Mediate Unique Plasticity onto Parvalbumin-Expressing Interneurons in Area CA2 of the Hippocampus. Journal of Neuroscience, 2013, 33 (36), pp.14567-14578. ⟨10.1523/JNEUROSCI.0649-13.2013⟩. ⟨inserm-02769098⟩
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