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            <funder>This work was supported by ‘‘La Ligue Nationale Contre le Cancer’’ throughout an ‘‘Equipe Labellise´e 2012’’ grant, by the ‘‘Institut National de la Santé et de la Recherche Médicale’’ (INSERM), by ‘‘La Région Paysde-la-Loire’’ throughout the Nuclear Technology for Health project (NucSan), and by the ‘‘Axe Vectorisation and Radiothérapies’’ and the ‘‘Réseau Gliome Grand Ouest" (ReGGO) of the ‘‘Cancéropôle Grand-Ouest’’. The co-authors of this manuscript are also members of the LabEx IRON ‘‘Innovative Radiopharmaceuticals in Oncology and Neurology’’ as part of the french government ‘‘Investissements d’Avenir’’ program.Delphine Séhédic was a Ph.D. student from the NucSan project and received a fellowship from ‘‘La Re´gion Pays-de-la-Loire’’.</funder>
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                <term xml:lang="en"> radioresistance</term>
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              <p>Radiotherapy is one of the standard treatments for glioblastoma, but its effectiveness often encounters the phenomenon of radioresistance. This resistance was recently attributed to distinct cell contingents known as glioblastoma stem-like cells (GSCs) and dominant clones. It is characterized in particular by the activation of signaling pathways and DNA repair mechanisms. Recent advances in the field of nanomedicine offer new possibilities for radiosensitizing these cell populations. Several strategies have been developed in this direction, the first consisting of encapsulating a contrast agent or synthesizing metal-based nanocarriers to concentrate the dose gradient at the level of the target tissue. In the second strategy the physicochemical properties of the vectors are used to encapsulate a wide range of pharmacological agents which act in synergy with the ionizing radiation to destroy the cancerous cells. This review reports on the various molecular anomalies present in GSCs and the predominant role of nanomedicines in the development of radiosensitization strategies.</p>
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