<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-01817955</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T16:04:57+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Molecular epidemiology of Acinetobacter baumannii in different hospitals in Tripoli, Lebanon using bla(OXA-51-like) sequence based typing</title>
            <author role="aut">
              <persName>
                <forename type="first">Rayane</forename>
                <surname>Rafei</surname>
              </persName>
              <idno type="halauthorid">1074814-0</idno>
              <affiliation ref="#struct-218557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Pailhoriès</surname>
              </persName>
              <idno type="halauthorid">930361-0</idno>
              <affiliation ref="#struct-218557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Monzer</forename>
                <surname>Hamze</surname>
              </persName>
              <email type="md5">7f689d149519745cc72d343779751060</email>
              <email type="domain">monzerhamze.com</email>
              <idno type="idhal" notation="numeric">955455</idno>
              <idno type="halauthorid" notation="string">822339-955455</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Matthieu</forename>
                <surname>Eveillard</surname>
              </persName>
              <email type="md5">138b5324822f7216eef2ee96fe8b598c</email>
              <email type="domain">chu-angers.fr</email>
              <idno type="idhal" notation="string">matthieu-eveillard</idno>
              <idno type="idhal" notation="numeric">749535</idno>
              <idno type="halauthorid" notation="string">46146-749535</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5916-3627</idno>
              <affiliation ref="#struct-218557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hassan</forename>
                <surname>Mallat</surname>
              </persName>
              <idno type="halauthorid">864266-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fouad</forename>
                <surname>Dabboussi</surname>
              </persName>
              <idno type="halauthorid">822338-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Joly-Guillou</surname>
              </persName>
              <idno type="halauthorid">1383535-0</idno>
              <affiliation ref="#struct-218557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Kempf</surname>
              </persName>
              <email type="md5">c18d7280f2be8e9dd23e771c7a428370</email>
              <email type="domain">chu-angers.fr</email>
              <idno type="idhal" notation="string">marie-kempf</idno>
              <idno type="idhal" notation="numeric">749532</idno>
              <idno type="halauthorid" notation="string">40693-749532</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2943-7500</idno>
              <idno type="IDREF">https://www.idref.fr/083381287</idno>
              <affiliation ref="#struct-218557"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Elizabeth</forename>
                <surname>Bernardo</surname>
              </persName>
              <email type="md5">373b15f895425e6af21c3cffa325a784</email>
              <email type="domain">univ-nantes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-06-18 15:30:23</date>
              <date type="whenModified">2025-10-03 03:05:23</date>
              <date type="whenReleased">2018-06-18 15:43:21</date>
              <date type="whenProduced">2015</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432822"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="326726">
                <persName>
                  <forename>Elizabeth</forename>
                  <surname>Bernardo</surname>
                </persName>
                <email type="md5">373b15f895425e6af21c3cffa325a784</email>
                <email type="domain">univ-nantes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-01817955</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-01817955</idno>
            <idno type="halBibtex">rafei:inserm-01817955</idno>
            <idno type="halRefHtml">&lt;i&gt;BMC Microbiology&lt;/i&gt;, 2015, 15 (1), &lt;a target="_blank" href="https://dx.doi.org/10.1186/s12866-015-0441-5"&gt;&amp;#x27E8;10.1186/s12866-015-0441-5&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">BMC Microbiology, 2015, 15 (1), &amp;#x27E8;10.1186/s12866-015-0441-5&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="CRCNA">Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS</idno>
            <idno type="stamp" n="CRCI2NA">Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-NANTES-AV2022">Université de Nantes</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Molecular epidemiology of Acinetobacter baumannii in different hospitals in Tripoli, Lebanon using bla(OXA-51-like) sequence based typing</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Rayane</forename>
                    <surname>Rafei</surname>
                  </persName>
                  <idno type="halauthorid">1074814-0</idno>
                  <affiliation ref="#struct-218557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Pailhoriès</surname>
                  </persName>
                  <idno type="halauthorid">930361-0</idno>
                  <affiliation ref="#struct-218557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Monzer</forename>
                    <surname>Hamze</surname>
                  </persName>
                  <email type="md5">7f689d149519745cc72d343779751060</email>
                  <email type="domain">monzerhamze.com</email>
                  <idno type="idhal" notation="numeric">955455</idno>
                  <idno type="halauthorid" notation="string">822339-955455</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Matthieu</forename>
                    <surname>Eveillard</surname>
                  </persName>
                  <email type="md5">138b5324822f7216eef2ee96fe8b598c</email>
                  <email type="domain">chu-angers.fr</email>
                  <idno type="idhal" notation="string">matthieu-eveillard</idno>
                  <idno type="idhal" notation="numeric">749535</idno>
                  <idno type="halauthorid" notation="string">46146-749535</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5916-3627</idno>
                  <affiliation ref="#struct-218557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hassan</forename>
                    <surname>Mallat</surname>
                  </persName>
                  <idno type="halauthorid">864266-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fouad</forename>
                    <surname>Dabboussi</surname>
                  </persName>
                  <idno type="halauthorid">822338-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Joly-Guillou</surname>
                  </persName>
                  <idno type="halauthorid">1383535-0</idno>
                  <affiliation ref="#struct-218557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Kempf</surname>
                  </persName>
                  <email type="md5">c18d7280f2be8e9dd23e771c7a428370</email>
                  <email type="domain">chu-angers.fr</email>
                  <idno type="idhal" notation="string">marie-kempf</idno>
                  <idno type="idhal" notation="numeric">749532</idno>
                  <idno type="halauthorid" notation="string">40693-749532</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2943-7500</idno>
                  <idno type="IDREF">https://www.idref.fr/083381287</idno>
                  <affiliation ref="#struct-218557"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">346</idno>
                <idno type="issn">1471-2180</idno>
                <title level="j">BMC Microbiology</title>
                <imprint>
                  <publisher>BioMed Central</publisher>
                  <biblScope unit="volume">15</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <date type="datePub">2015</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1186/s12866-015-0441-5</idno>
              <idno type="pubmedcentral">PMC4432822</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND: A. baumannii has emerged as an important nosocomial pathogen with an outstanding ability to acquire multidrug resistant mechanisms. In this study, we investigate the molecular epidemiology and carbapenem resistance mechanisms of A. baumannii in Tripoli, Northern Lebanon.METHODS: One hundred sixteen non-duplicate isolates isolated between 2011 and 2013 in different hospitals in Tripoli, Lebanon from Lebanese patients and wounded Syrian patients during Syrian war were studied. Antibiotic susceptibility testing was determined by agar disc diffusion and Etest. Carbapenemase-encoding genes were investigated by PCR. All isolates were typed by bla OXA-51-like sequence based typing (SBT) and 57 isolates were also analysed by MLST using Pasteur's scheme followed by eBURST analysis.RESULTS: Of the 116 isolates, 70 (60 %) showed a carbapenem resistance phenotype. The bla OXA-23 with an upstream insertion of ISAba1 was the major carbapenem resistance mechanism and detected in 65 isolates. Five isolates, including four from wounded Syrian patients and one from a Lebanese patient, were positive for bla NDM-1. bla OXA-51-like SBT revealed the presence of 14 variants, where bla OXA-66 was the most common and present in 73 isolates, followed by bla OXA-69 in 20 isolates. MLST analysis identified 17 sequence types (ST) and showed a concordance with bla OXA-51-like SBT. Each clonal complex (CC) had a specific bla OXA-51-like sequence such as CC2, which harboured bla OXA-66 variant, and CC1 harbouring bla OXA-69 variant. NDM-1 producing isolates belonged to ST85 (4 Syrian isolates) and ST25 (1 Lebanese isolate).CONCLUSIONS: Our results showed a successful predominance of international clone 2 with a widespread occurrence of OXA-23 carbapenemase in Lebanese hospitals. These findings emphasise the urgent need of effective measures to control the spread of A. baumannii in this country.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-218557" status="OLD">
          <orgName>Centre de Recherche en Cancérologie Nantes-Angers</orgName>
          <orgName type="acronym">CRCNA</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-151939" type="direct"/>
            <relation name="U892" active="#struct-303623" type="direct"/>
            <relation name="UMR6299" active="#struct-441569" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
            <relation active="#struct-531638" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>