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            <title xml:lang="en">Using Vitek MALDI-TOF mass spectrometry to identify species belonging to the Acinetobacter calcoaceticus–Acinetobacter baumannii complex: a relevant alternative to molecular biology?</title>
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                <forename type="first">Hélène</forename>
                <surname>Pailhories</surname>
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                <forename type="first">Sophie</forename>
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                <forename type="first">Matthieu</forename>
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                <forename type="first">Marie</forename>
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            <idno type="halRefHtml">&lt;i&gt;Diagnostic Microbiology and Infectious Disease&lt;/i&gt;, 2015, 83 (2), pp.99 - 104. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.diagmicrobio.2015.06.009"&gt;&amp;#x27E8;10.1016/j.diagmicrobio.2015.06.009&amp;#x27E9;&lt;/a&gt;</idno>
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            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
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            <idno type="stamp" n="CRCI2NA">Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-NANTES-AV2022">Université de Nantes</idno>
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                <title xml:lang="en">Using Vitek MALDI-TOF mass spectrometry to identify species belonging to the Acinetobacter calcoaceticus–Acinetobacter baumannii complex: a relevant alternative to molecular biology?</title>
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                  <persName>
                    <forename type="first">Hélène</forename>
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                    <forename type="first">Sophie</forename>
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                    <forename type="first">Matthieu</forename>
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                    <forename type="first">Marie</forename>
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                    <forename type="first">Marie</forename>
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                <idno type="issn">0732-8893</idno>
                <idno type="eissn">1879-0070</idno>
                <title level="j">Diagnostic Microbiology and Infectious Disease</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">83</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">99 - 104</biblScope>
                  <date type="datePub">2015-10</date>
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                <term xml:lang="en"> Vitek MS® plus</term>
                <term xml:lang="en"> SuperSpectrum</term>
                <term xml:lang="en"> SARAMIS™</term>
                <term xml:lang="en"> MALDI-TOF mass spectrometry</term>
                <term xml:lang="en"> Acinetobacter pittii</term>
                <term xml:lang="en">Acinetobacter baumannii</term>
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              <p>Acinetobacter baumannii belongs to the Acinetobacter calcoaceticus-baumannii complex (Acb) containing 2 other pathogenic species: Acinetobacter pittii and Acinetobacter nosocomialis. Identification of these bacteria remains problematic despite the use of matrix-assisted laser ionization time-of-flight mass spectrometry (MALDI-TOF MS). Here, we enriched the SARAMIS™ database of the Vitek MS® plus mass spectrometer to improve the identification of species of the Acb complex. For each species, we incremented reference spectra. Then, a SuperSpectrum was created based on the selection of 40 specific masses. In a second step, we validated reference spectra and SuperSpectra with 100 isolates identified by rpoB gene sequencing. All the isolates were correctly identified by MALDI-TOF MS with the database we created as compared to the identifications obtained by rpoB sequencing. Our database enabled rapid and reliable identification of the pathogen species belonging to the Acb complex. Identification by MALDI-TOF MS with our database is a good alternative to molecular biology.</p>
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