<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-01414260</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T02:40:19+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Quantitative evaluation of Therapeutic response by FDG-PET–CT in Metastatic Breast Cancer</title>
            <author role="crp">
              <persName>
                <forename type="first">Dorothée</forename>
                <surname>Goulon</surname>
              </persName>
              <email type="md5">ff98a3b3c7125b240cf291dbdec29dea</email>
              <email type="domain">hotmail.fr</email>
              <idno type="idhal" notation="numeric">995890</idno>
              <idno type="halauthorid" notation="string">1092596-995890</idno>
              <affiliation ref="#struct-444080"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hatem</forename>
                <surname>Necib</surname>
              </persName>
              <idno type="halauthorid">1092195-0</idno>
              <affiliation ref="#struct-475793"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Brice</forename>
                <surname>Henaff</surname>
              </persName>
              <idno type="halauthorid">1092196-0</idno>
              <affiliation ref="#struct-111537"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Rousseau</surname>
              </persName>
              <idno type="idhal" notation="numeric">768474</idno>
              <idno type="halauthorid" notation="string">586580-768474</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0455-0523</idno>
              <affiliation ref="#struct-218557"/>
              <affiliation ref="#struct-444080"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thomas</forename>
                <surname>Carlier</surname>
              </persName>
              <email type="md5">c6e3cc1c6ceed1261fb3e623221fb859</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">762050</idno>
              <idno type="halauthorid" notation="string">433406-762050</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6932-7322</idno>
              <idno type="IDREF">https://www.idref.fr/127024263</idno>
              <affiliation ref="#struct-218557"/>
              <affiliation ref="#struct-111537"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Françoise</forename>
                <surname>Kraeber-Bodere</surname>
              </persName>
              <email type="md5">9480af72d9b9633f9778af8a03cc9020</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">1335905</idno>
              <idno type="halauthorid" notation="string">704846-1335905</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3417-0759</idno>
              <idno type="IDREF">https://www.idref.fr/073740314</idno>
              <affiliation ref="#struct-218557"/>
              <affiliation ref="#struct-111537"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Elizabeth</forename>
                <surname>Bernardo</surname>
              </persName>
              <email type="md5">373b15f895425e6af21c3cffa325a784</email>
              <email type="domain">univ-nantes.fr</email>
            </editor>
            <funder ref="#projanr-37462"/>
            <funder ref="#projanr-26984"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2016-12-12 11:15:19</date>
              <date type="whenModified">2026-04-24 13:36:03</date>
              <date type="whenReleased">2016-12-12 15:19:50</date>
              <date type="whenProduced">2016</date>
              <date type="whenEndEmbargoed">2016-12-12</date>
              <ref type="file" target="https://inserm.hal.science/inserm-01414260v1/document">
                <date notBefore="2016-12-12"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inserm.hal.science/inserm-01414260v1/file/2016Art1Eq13.pdf" id="file-1414260-1500292">
                <date notBefore="2016-12-12"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861036"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="326726">
                <persName>
                  <forename>Elizabeth</forename>
                  <surname>Bernardo</surname>
                </persName>
                <email type="md5">373b15f895425e6af21c3cffa325a784</email>
                <email type="domain">univ-nantes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-01414260</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-01414260</idno>
            <idno type="halBibtex">goulon:inserm-01414260</idno>
            <idno type="halRefHtml">&lt;i&gt;Frontiers in Medicine&lt;/i&gt;, 2016, 3, pp.19. &lt;a target="_blank" href="https://dx.doi.org/10.3389/fmed.2016.00019"&gt;&amp;#x27E8;10.3389/fmed.2016.00019&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Frontiers in Medicine, 2016, 3, pp.19. &amp;#x27E8;10.3389/fmed.2016.00019&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-1414260-1500292"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="CRCNA">Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="CRCI2NA">Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-NANTES-AV2022">Université de Nantes</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Quantitative evaluation of Therapeutic response by FDG-PET–CT in Metastatic Breast Cancer</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Dorothée</forename>
                    <surname>Goulon</surname>
                  </persName>
                  <email type="md5">ff98a3b3c7125b240cf291dbdec29dea</email>
                  <email type="domain">hotmail.fr</email>
                  <idno type="idhal" notation="numeric">995890</idno>
                  <idno type="halauthorid" notation="string">1092596-995890</idno>
                  <affiliation ref="#struct-444080"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hatem</forename>
                    <surname>Necib</surname>
                  </persName>
                  <idno type="halauthorid">1092195-0</idno>
                  <affiliation ref="#struct-475793"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Brice</forename>
                    <surname>Henaff</surname>
                  </persName>
                  <idno type="halauthorid">1092196-0</idno>
                  <affiliation ref="#struct-111537"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Rousseau</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">768474</idno>
                  <idno type="halauthorid" notation="string">586580-768474</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0455-0523</idno>
                  <affiliation ref="#struct-218557"/>
                  <affiliation ref="#struct-444080"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thomas</forename>
                    <surname>Carlier</surname>
                  </persName>
                  <email type="md5">c6e3cc1c6ceed1261fb3e623221fb859</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">762050</idno>
                  <idno type="halauthorid" notation="string">433406-762050</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6932-7322</idno>
                  <idno type="IDREF">https://www.idref.fr/127024263</idno>
                  <affiliation ref="#struct-218557"/>
                  <affiliation ref="#struct-111537"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Françoise</forename>
                    <surname>Kraeber-Bodere</surname>
                  </persName>
                  <email type="md5">9480af72d9b9633f9778af8a03cc9020</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">1335905</idno>
                  <idno type="halauthorid" notation="string">704846-1335905</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3417-0759</idno>
                  <idno type="IDREF">https://www.idref.fr/073740314</idno>
                  <affiliation ref="#struct-218557"/>
                  <affiliation ref="#struct-111537"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">104429</idno>
                <idno type="issn">2296-858X</idno>
                <title level="j">Frontiers in Medicine</title>
                <imprint>
                  <publisher>Frontiers media</publisher>
                  <biblScope unit="volume">3</biblScope>
                  <biblScope unit="pp">19</biblScope>
                  <date type="datePub">2016</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3389/fmed.2016.00019</idno>
              <idno type="pubmed">27243012</idno>
              <idno type="pubmedcentral">PMC4861036</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">SUL</term>
                <term xml:lang="en"> positive predictive value</term>
                <term xml:lang="en">ROC</term>
                <term xml:lang="en"> receiver operating characteristic</term>
                <term xml:lang="en">ROI</term>
                <term xml:lang="en"> region of interest</term>
                <term xml:lang="en">SAM</term>
                <term xml:lang="en"> standardized added metabolic activity</term>
                <term xml:lang="en">SULTAN</term>
                <term xml:lang="en"> longitudinal monitoring in positron factor analysis</term>
                <term xml:lang="en"> true positive</term>
                <term xml:lang="en"> SUV lean body mass</term>
                <term xml:lang="en">SUV</term>
                <term xml:lang="en"> standard uptake value</term>
                <term xml:lang="en">TLG</term>
                <term xml:lang="en"> total lesion glycolysis</term>
                <term xml:lang="en">TN</term>
                <term xml:lang="en"> true negative</term>
                <term xml:lang="en">TP</term>
                <term xml:lang="en">FDG</term>
                <term xml:lang="en"> PeT</term>
                <term xml:lang="en"> breast cancer</term>
                <term xml:lang="en"> PercisT</term>
                <term xml:lang="en"> therapeutic evaluation</term>
                <term xml:lang="en"> parametric analysis</term>
                <term xml:lang="en"> sUlTan Abbreviations: AUC</term>
                <term xml:lang="en"> area under curve</term>
                <term xml:lang="en">EORTC</term>
                <term xml:lang="en"> European Organization for Research and Treatment of Cancer</term>
                <term xml:lang="en">FADS</term>
                <term xml:lang="en"> factor analysis of dynamic sequences</term>
                <term xml:lang="en">PPV</term>
                <term xml:lang="en"> fluorodeoxyglucose</term>
                <term xml:lang="en">FN</term>
                <term xml:lang="en"> false negative</term>
                <term xml:lang="en">FP</term>
                <term xml:lang="en"> false positive</term>
                <term xml:lang="en">MRI</term>
                <term xml:lang="en"> magnetic resonance imaging</term>
                <term xml:lang="en">MV</term>
                <term xml:lang="en"> metabolic volume</term>
                <term xml:lang="en">NPV</term>
                <term xml:lang="en"> negative predictive value</term>
                <term xml:lang="en">PET</term>
                <term xml:lang="en"> positron emission tomography</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Purpose: To assess the therapeutic response for metastatic breast cancer with 18 F-FDG position emission tomography (PET), this retrospective study aims to compare the performance of six different metabolic metrics with PERCIST, PERCIST with optimal thresholds, and an image-based parametric approach. Methods: Thirty-six metastatic breast cancer patients underwent 128 PET scans and 123 lesions were identified. In a per-lesion and per-patient analysis, the performance of six metrics: maximum standardized uptake value (SUVmax), SUVpeak, standardized added metabolic activity (SAM), SUVmean, metabolic volume (MV), total lesion glycolysis (TLG), and a parametric approach (SULTAN) were determined and compared to the gold standard (defined by clinical assessment and biological and conventional imaging according RECIST 1.1). The evaluation was performed using PERCIST thresholds (for per-patient analysis only) and optimal thresholds (determined by the Youden criterion from the receiver operating characteristic curves). results: In the per-lesion analysis, 210 pairs of lesion evolutions were studied. Using the optimal thresholds, SUVmax, SUVpeak, SUVmean, SAM, and TLG were significantly correlated with the gold standard. SUVmax, SUVpeak, and SUVmean reached the best sensitivity (91, 88, and 83%, respectively), specificity (93, 95, and 97%, respectively), and negative predictive value (NPV, 90, 88, and 83%, respectively). For the per-patient analysis, 79 pairs of PET were studied. The optimal thresholds compared to the PERCIST threshold did not improve performance for SUVmax, SUVpeak, and SUVmean. Only SUVmax, SUVpeak, SUVmean, and TLG were correlated with the gold standard. SULTAN also performed equally: 83% sensitivity, 88% specificity, and NPV 86%. conclusion: This study showed that SUVmax and SUVpeak were the best parameters for PET evaluation of metastatic breast cancer lesions. Parametric imaging is helpful in evaluating serial studies.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-444080" status="VALID">
          <idno type="ROR">https://ror.org/01m6as704</idno>
          <orgName>Institut de Cancérologie de l'Ouest [Angers/Nantes]</orgName>
          <orgName type="acronym">UNICANCER/ICO</orgName>
          <desc>
            <address>
              <addrLine>15, rue André Boquel - 49055 Angers cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-cancerologie-ouest.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-502406" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-475793" status="INCOMING">
          <orgName>Service de Radiologie [Nantes]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-474972" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-111537" status="VALID">
          <orgName>Service de Médecine Nucléaire [Nantes]</orgName>
          <desc>
            <address>
              <addrLine>1 place Alexis Ricordeau 44093 Nantes Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nantes.fr/medecine-nucleaire-hotel-dieu-492.kjsp</ref>
          </desc>
          <listRelation>
            <relation active="#struct-475892" type="direct"/>
            <relation active="#struct-474972" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-218557" status="OLD">
          <orgName>Centre de Recherche en Cancérologie Nantes-Angers</orgName>
          <orgName type="acronym">CRCNA</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-151939" type="direct"/>
            <relation name="U892" active="#struct-303623" type="direct"/>
            <relation name="UMR6299" active="#struct-441569" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
            <relation active="#struct-531638" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-502406" status="VALID">
          <orgName>UNICANCER</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75654 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicancer.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-475892" status="VALID">
          <orgName>Hôpital Guillaume-et-René-Laennec [CHU Nantes]</orgName>
          <desc>
            <address>
              <addrLine>Boulevard Jacques-Monod Saint-Herblain 44093 Nantes Cedex 1</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-474972" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-37462" status="VALID">
          <idno type="anr">ANR-11-EQPX-0004</idno>
          <orgName>ARRONAXPLUS</orgName>
          <desc>Nucléaire pour la Santé</desc>
          <date type="start">2011</date>
        </org>
        <org type="anrProject" xml:id="projanr-26984" status="VALID">
          <idno type="anr">ANR-11-LABX-0018</idno>
          <orgName>IRON</orgName>
          <desc>Radiopharmaceutiques Innovants en Oncologie et Neurologie</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>