<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-01333918</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T01:42:11+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines.</title>
            <author role="crp">
              <persName>
                <forename type="first">Mbaye Diaw</forename>
                <surname>Dioum</surname>
              </persName>
              <email type="md5">9654f5a3d4a59a668ad651efc7031e60</email>
              <email type="domain">yahoo.fr</email>
              <idno type="idhal" notation="numeric">983811</idno>
              <idno type="halauthorid" notation="string">1039010-983811</idno>
              <affiliation ref="#struct-1175215"/>
              <affiliation ref="#struct-59514"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Matar</forename>
                <surname>Seck</surname>
              </persName>
              <idno type="halauthorid">758561-0</idno>
              <affiliation ref="#struct-1175215"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Virginie</forename>
                <surname>Silvestre</surname>
              </persName>
              <idno type="halauthorid">672188-0</idno>
              <affiliation ref="#struct-59514"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurélien</forename>
                <surname>Planchat</surname>
              </persName>
              <idno type="halauthorid">666493-0</idno>
              <affiliation ref="#struct-59514"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Denis</forename>
                <surname>Loquet</surname>
              </persName>
              <idno type="halauthorid">993080-0</idno>
              <affiliation ref="#struct-59514"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Steven</forename>
                <surname>Lohard</surname>
              </persName>
              <idno type="halauthorid">1038958-0</idno>
              <affiliation ref="#struct-218557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Barille-Nion</surname>
              </persName>
              <email type="md5">bf47dabd5bf31eae9a92a33a466ad4b8</email>
              <email type="domain">univ-nantes.fr</email>
              <idno type="idhal" notation="string">sophie-barille-nion</idno>
              <idno type="idhal" notation="numeric">181683</idno>
              <idno type="halauthorid" notation="string">1039011-181683</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5171-9937</idno>
              <idno type="IDREF">https://www.idref.fr/130994251</idno>
              <affiliation ref="#struct-218557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gérald</forename>
                <surname>Remaud</surname>
              </persName>
              <idno type="halauthorid">123329-0</idno>
              <affiliation ref="#struct-59514"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Richard</forename>
                <forename type="middle">J</forename>
                <surname>Robins</surname>
              </persName>
              <idno type="halauthorid">1039013-0</idno>
              <affiliation ref="#struct-59514"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Illa</forename>
                <surname>Tea</surname>
              </persName>
              <email type="md5">ac9a7d9ab364e81893d84242a73f82db</email>
              <email type="domain">univ-nantes.fr</email>
              <idno type="idhal" notation="string">illa-tea</idno>
              <idno type="idhal" notation="numeric">1340361</idno>
              <idno type="halauthorid" notation="string">953174-1340361</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5369-7206</idno>
              <affiliation ref="#struct-59514"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Elizabeth</forename>
                <surname>Bernardo</surname>
              </persName>
              <email type="md5">373b15f895425e6af21c3cffa325a784</email>
              <email type="domain">univ-nantes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2016-06-20 10:52:57</date>
              <date type="whenModified">2025-10-03 03:05:14</date>
              <date type="whenReleased">2016-06-20 11:36:05</date>
              <date type="whenProduced">2016-05-25</date>
              <date type="whenEndEmbargoed">9999-12-31</date>
              <ref type="file" target="https://inserm.hal.science/inserm-01333918v1/document">
                <date notBefore="9999-12-31"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inserm.hal.science/inserm-01333918v1/file/2016-%20PLAMED-2015-12-1263-OP.pdf" id="file-1333918-1414306">
                <date notBefore="9999-12-31"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="326726">
                <persName>
                  <forename>Elizabeth</forename>
                  <surname>Bernardo</surname>
                </persName>
                <email type="md5">373b15f895425e6af21c3cffa325a784</email>
                <email type="domain">univ-nantes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-01333918</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-01333918</idno>
            <idno type="halBibtex">dioum:inserm-01333918</idno>
            <idno type="halRefHtml">&lt;i&gt;Planta Medica&lt;/i&gt;, 2016, &lt;a target="_blank" href="https://dx.doi.org/10.1055/s-0042-107797"&gt;&amp;#x27E8;10.1055/s-0042-107797&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Planta Medica, 2016, &amp;#x27E8;10.1055/s-0042-107797&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-1333918-1414306"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="CRCNA">Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS</idno>
            <idno type="stamp" n="CEISAM">Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation</idno>
            <idno type="stamp" n="CRCI2NA">Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-NANTES-AV2022">Université de Nantes</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines.</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Mbaye Diaw</forename>
                    <surname>Dioum</surname>
                  </persName>
                  <email type="md5">9654f5a3d4a59a668ad651efc7031e60</email>
                  <email type="domain">yahoo.fr</email>
                  <idno type="idhal" notation="numeric">983811</idno>
                  <idno type="halauthorid" notation="string">1039010-983811</idno>
                  <affiliation ref="#struct-1175215"/>
                  <affiliation ref="#struct-59514"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Matar</forename>
                    <surname>Seck</surname>
                  </persName>
                  <idno type="halauthorid">758561-0</idno>
                  <affiliation ref="#struct-1175215"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Virginie</forename>
                    <surname>Silvestre</surname>
                  </persName>
                  <idno type="halauthorid">672188-0</idno>
                  <affiliation ref="#struct-59514"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurélien</forename>
                    <surname>Planchat</surname>
                  </persName>
                  <idno type="halauthorid">666493-0</idno>
                  <affiliation ref="#struct-59514"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Denis</forename>
                    <surname>Loquet</surname>
                  </persName>
                  <idno type="halauthorid">993080-0</idno>
                  <affiliation ref="#struct-59514"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Steven</forename>
                    <surname>Lohard</surname>
                  </persName>
                  <idno type="halauthorid">1038958-0</idno>
                  <affiliation ref="#struct-218557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Barille-Nion</surname>
                  </persName>
                  <email type="md5">bf47dabd5bf31eae9a92a33a466ad4b8</email>
                  <email type="domain">univ-nantes.fr</email>
                  <idno type="idhal" notation="string">sophie-barille-nion</idno>
                  <idno type="idhal" notation="numeric">181683</idno>
                  <idno type="halauthorid" notation="string">1039011-181683</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5171-9937</idno>
                  <idno type="IDREF">https://www.idref.fr/130994251</idno>
                  <affiliation ref="#struct-218557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gérald</forename>
                    <surname>Remaud</surname>
                  </persName>
                  <idno type="halauthorid">123329-0</idno>
                  <affiliation ref="#struct-59514"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Richard</forename>
                    <forename type="middle">J</forename>
                    <surname>Robins</surname>
                  </persName>
                  <idno type="halauthorid">1039013-0</idno>
                  <affiliation ref="#struct-59514"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Illa</forename>
                    <surname>Tea</surname>
                  </persName>
                  <email type="md5">ac9a7d9ab364e81893d84242a73f82db</email>
                  <email type="domain">univ-nantes.fr</email>
                  <idno type="idhal" notation="string">illa-tea</idno>
                  <idno type="idhal" notation="numeric">1340361</idno>
                  <idno type="halauthorid" notation="string">953174-1340361</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5369-7206</idno>
                  <affiliation ref="#struct-59514"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">18058</idno>
                <idno type="issn">0032-0943</idno>
                <idno type="eissn">1439-0221</idno>
                <title level="j">Planta Medica</title>
                <imprint>
                  <publisher>Georg Thieme Verlag</publisher>
                  <date type="datePub">2016-05-25</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1055/s-0042-107797</idno>
              <idno type="pubmed">27224268</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The seeds of Carapa procera are exploited extensivelyin West African ethnopharmacy for thetreatment of several pathologies, including inflammation.They also are effective as insect antifeedantsand as a mosquito repellent. With theaim of identifying bioactive principles, an ethylacetate extract of the defatted seeds was madeand fractionated. Two principle compounds wereisolated. One of these, 5,6-dehydro-7-deacetoxy-7-oxogedunin (1), while known from another genusof the Meliaceae, is newly identified from thegenus Carapa and its X‑ray structure is describedfor the first time. In addition, 1 displayed stronganti-clonogenic activity at 10 μM. The other compound,mexicanolide (2), is known from thisspecies and showed neither cytotoxicity nor anticlonogenicity.These differences in efficacy arediscussed in relation to known structure-activityrelationships of limonoids.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-1175215" status="VALID">
          <idno type="ROR">https://ror.org/04je6yw13</idno>
          <orgName>Université Cheikh Anta Diop de Dakar [Sénégal]</orgName>
          <orgName type="acronym">UCAD</orgName>
          <date type="start">1987-01-01</date>
          <desc>
            <address>
              <addrLine>Université Cheikh Anta Diop de Dakar - Rectorat, BP 5005 Dakar-fann</addrLine>
              <country key="SN"/>
            </address>
            <ref type="url">https://www.ucad.sn/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-59514" status="OLD">
          <idno type="IdRef">185977650</idno>
          <idno type="ISNI">0000000403857229</idno>
          <idno type="RNSR">200812273K</idno>
          <idno type="ROR">https://ror.org/04ysg2a58</idno>
          <orgName>Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation</orgName>
          <orgName type="acronym">CEISAM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>UFR des Sciences et des Techniques - 2 rue de la Houssiniere BP 92208 - 44322 NANTES Cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ceisam.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-97058" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR6230" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-218557" status="OLD">
          <orgName>Centre de Recherche en Cancérologie Nantes-Angers</orgName>
          <orgName type="acronym">CRCNA</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-151939" type="direct"/>
            <relation name="U892" active="#struct-303623" type="direct"/>
            <relation name="UMR6299" active="#struct-441569" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
            <relation active="#struct-531638" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-97058" status="OLD">
          <orgName>Université de Nantes - UFR des Sciences et des Techniques</orgName>
          <orgName type="acronym">UN UFR ST</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>2, rue de la Houssinière - BP 92208 - 44322 Nantes cedex 3</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sciences-techniques.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-151939" status="VALID">
          <idno type="ISNI">0000 0004 0472 0283</idno>
          <idno type="ROR">https://ror.org/0250ngj72</idno>
          <orgName>Centre Hospitalier Universitaire d'Angers</orgName>
          <orgName type="acronym">CHU Angers</orgName>
          <desc>
            <address>
              <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>