Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2015

Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer

Résumé

A subtype of metastatic breast cancer has recently been identified, in which netrin-1 is over-expressed. Netrin-1 binds to dependence receptors inducing survival, while its absence actively triggers apoptosis. An anti-netrin-1 therapy is under development , which disrupts ligand-receptor interaction and induces apoptosis. To identify potential responders for such a targeted therapy, netrin-1 expression has to be analyzed. Molecular imaging with ultrasound (US) is able to detect the expression of a specific protein when using targeted contrast agents. Thus, we aim to develop an US molecular imaging approach using microbubbles (MB) functionalized with an anti-netrin-1 antibody. Binding was tested on purified netrin-1 protein in static and dynamic conditions. Anti-netrin-1 MB were validated in in-vitro assays and will be further tested in pre-clinical studies using metastatic breast cancer animal models.
Fichier principal
Vignette du fichier
ACTES-RITS2015-HAL-p150-1.pdf (95.96 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-01155018 , version 1 (26-05-2015)

Licence

Paternité

Identifiants

  • HAL Id : inserm-01155018 , version 1

Citer

Jennifer Wischhusen, Jean-Guy Delcros, Patrick Mehlen, Frédéric Padilla. Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer. Journées RITS 2015, Mar 2015, Dourdan, France. pp 150-151. ⟨inserm-01155018⟩
260 Consultations
273 Téléchargements

Partager

Gmail Facebook X LinkedIn More